[특허]Delayed onset transdermal delivery device

Delayed onset transdermal delivery device 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-013/02
출원번호	US-0271122 (1988-11-14)
발명자 / 주소	Lee Eun Soo (Redwood City CA) Theeuwes Felix (Los Altos Hills CA) Wong S. L. Patrick (Hayward CA) Yum Su Il (Los Altos CA) Zaffaroni Alejandro (Atherton CA)
출원인 / 주소	Alza Corporation (Palo Alto CA 02)
인용정보	피인용 횟수 : 77 인용 특허 : 0

초록 ▼

A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability emables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continous administration over extended time periods.

대표청구항 ▼

A controlled release medical device for delivering at least one drug to the skin or mucosa and adapted to delay the onset of drug delivery at a therapeutically effective rate for a predetermined time after application of said device to the skin or mucosa, said device comprising, in combination: a drug containing reservoir having a surface through which said drug is released to the skin or mucosa; and a drug release delay membrane comprised of a hydrophilic or semihydrophilic polymer disposed between the skin or mucosa and the releasing surface of said reservoir, said delay membrane being substantially free of undissolved drug and being impermeable to said drug in a dry state and permeable thereto in a hydrated state; whereby said drug must pass through said delay membrane to reach the skin or mucosa and whereby release of said drug from said reservoir to the skin or mucosa at said therapeutically effective rate is delayed until the delay membrane is converted from its dry state to its hydrated state.

이 특허를 인용한 특허 (77)

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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Delayed onset transdermal delivery device 원문보기

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Delayed onset transdermal delivery device 원문보기

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