[특허]Solid phase analytical device and method for using same

Solid phase analytical device and method for using same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12Q-001/70 C12Q-001/14 G01N-021/00
출원번호	US-0528277 (1990-05-21)
발명자 / 주소	Brown William E. (Grayslake IL) Clemens John M. (Gurnee IL) Devereaux Sharon M. (Gurnee IL) Hofler John G. (Ingleside IL) Knigge Kevin M. (Wheeling IL) Safford Sarah E. (Libertyville IL)
출원인 / 주소	Abbott Laboratories (North Chicago IL 02)
인용정보	피인용 횟수 : 82 인용 특허 : 0

초록 ▼

A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

대표청구항 ▼

A method for determining the presence or amount of an analyte in a fluid, comprising the steps of: a) incubating a sample of the fluid with a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns, the particles having immobilized upon their surfaces a binding substance which specifically binds the analyte, whereby the analyte becomes bound to the substance to form an analyte/binding substance complex on the particles; b) contacting a porous, fibrous matrix with the incubated particles, wherein the average diameter of said particles is less than the particle retention rating of said matrix and whereby at least a portion of the incubated particles become retained and immobilized within the matrix upon at least a portion of the fibers thereof; c) contacting said fibrous matrix containing the complex of the particles with a with a labeled substance capable of specifically binding the analyte, said labeled substance capable of producing a detectable response in the presence of the analyte and an indicator substance, whereby the labeled substance becomes bound to the complex on the particles; d) washing unbound labeled substance from said fibrous matrix; e) contacting said fibrous matrix with the indicator substance; and f) detecting the response produced as a function of the presence or amount of analyte in the sample. A solid-phase assay device useful in a binding assay to determine the presence or an amount of an analyte in a fluid sample comprising a) a rigid carrier means for holding a porous matrix of fibers, b) a porous matrix of fibers arranged in a substantially planar layer having a first sample-contacting surface and a second surface opposed to said first surface, said matrix being disposed in said carrier means such that, when the device is used in the performance of an assay, at least a portion of the sample contacting the first surface passes through said substantially planar layer to the second surface, and c) substantially spherical, solid particles retained and immobilized on the fibers of said porous matrix, said particles having a substance adsorbed or bound to their surfaces which specifically binds analyte, said coated particles having an average diameter between about 0.1 and about 5 microns and wherein the average diameter of said particles is less than the particle retention rating of said porous matrix.

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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Solid phase analytical device and method for using same 원문보기

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Solid phase analytical device and method for using same 원문보기

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