초록 ▼

A composition comprising a polymer having dispersed therethrough a prostacyclin derivative selected from the group consisting of compounds of formula (I): [Figure] (I) (in which R1 represents hydrogen or lower alkyl, R2 represents a C3-C12 alkyl group or a C3-C12 alkenyl group; and n is an integer f

A composition comprising a polymer having dispersed therethrough a prostacyclin derivative selected from the group consisting of compounds of formula (I): [Figure] (I) (in which R1 represents hydrogen or lower alkyl, R2 represents a C3-C12 alkyl group or a C3-C12 alkenyl group; and n is an integer from 1 to 5; and pharmaceutically acceptable salts thereof) can be used to make a medical appliance from which the prostaglandin, having antithrombotic properties, will be released gradually and in a controlled way.

대표청구항 ▼

A medical appliance wherein at least a surface portion thereof is composed of an antithrombotic composition comprising a medically acceptable polymer having distributed therethrough an antithrombotic effective amount of a prostacyclin or mixture prostacyclins selected from the group consisting of co

A medical appliance wherein at least a surface portion thereof is composed of an antithrombotic composition comprising a medically acceptable polymer having distributed therethrough an antithrombotic effective amount of a prostacyclin or mixture prostacyclins selected from the group consisting of compounds of formula (I): [Figure] (I) in which: R1 represents a hydrogen atom or a C1-C6 alkyl group; R2 represents a C3-C12 alkyl group or a C3-C12 alkenyl group; and n is an integer of from 1 to 5; and pharmaceutically acceptable salts thereof, and wherein said polymer is silicone.