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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0614915 (1990-11-16) |
발명자 / 주소 |
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인용정보 | 피인용 횟수 : 347 인용 특허 : 0 |
The present invention is directed to a method and device for enhancing the implantation and differentiation of marrow-derived mesenchymal cells (i.e. mesenchymal stem cells). The method and device of the invention are an effective means for treating skeletal and other connective tissue disorders.
A method for inducing human marrow-derived mesenchymal stem cells to differentiate into bone-forming cells, comprising: a) providing human marrow-derived mesenchymal stem cells that have been isolated, purified and culturally expanded from a bone marrow specimen by adding the bone marrow specimen to
A method for inducing human marrow-derived mesenchymal stem cells to differentiate into bone-forming cells, comprising: a) providing human marrow-derived mesenchymal stem cells that have been isolated, purified and culturally expanded from a bone marrow specimen by adding the bone marrow specimen to a medium which contains factors which stimulate mesenchymal cell growth without differentiation and allows, when cultured, for selective adherence of only the mesenchymal stem cells to a substrate surface; b) applying the isolated, purified and culturally expanded human marrow-derived mesenchymal stem cells to a porous carrier; and, c) implanting the porous carrier containing the culturally expanded human marrow-derived mesenchymal stem cells into an environment containing factors necessary for differentiating the human mesenchymal stem cells into bone cells.
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