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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0627631 (1990-12-14) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 308 인용 특허 : 0 |
Stimulated Raman spectroscopy is used to non-invasively measure the concentration of an Raman active molecule, preferably D-glucose in the ocular aqueous humor of living being. The apparatus and method make use of two monochromatic laser beams, a pump laser beam and a probe laser beam. The output po
Stimulated Raman spectroscopy is used to non-invasively measure the concentration of an Raman active molecule, preferably D-glucose in the ocular aqueous humor of living being. The apparatus and method make use of two monochromatic laser beams, a pump laser beam and a probe laser beam. The output power of the pump laser beam is amplitude modulated, combined with the probe laser beam and directed into the ocular aqueous humor. The introduction of the laser beams into the ocular aqueous humor induces scattered Raman radiation, which causes a portion of the energy at the pump frequency to shift over to the probe frequency. The pump and probe laser beams are then detected as they exit the ocular aqueous humor. The probe laser beam is filtered, converted into an electrical signal and amplified. It is then compared to the modulation signal to generate an electrical signal representative of the concentration of D-glucose in the ocular aqueous humor.
An apparatus for non-invasively measuring the concentration of an Raman active molecule in ocular aqueous humor using stimulated Raman spectroscopy, comprising: means for generating a modulation signal; means for emitting a probe laser beam having a first wavelength; means for emitting a pump laser
An apparatus for non-invasively measuring the concentration of an Raman active molecule in ocular aqueous humor using stimulated Raman spectroscopy, comprising: means for generating a modulation signal; means for emitting a probe laser beam having a first wavelength; means for emitting a pump laser beam having a second wavelength differing from said first wavelength by a third wavelength selected to be within a characteristic Raman shift spectrum for the Raman active molecule; modulating means for modulating said pump laser beam using said modulation signal; means for directing said probe laser beam and said modulated pump laser beam into the ocular aqueous humor thereby stimulating Raman scattered radiation, said Raman scattered radiation inducing fluctuations in said probe laser beam said fluctuation being related to the concentration of the Raman active molecule in the ocular aqueous humor; said probe laser beam exiting the ocular aqueous humor; means for detecting the probe laser beam after it exits the ocular aqueous humor; means for converting said detected probe laser beam into a Raman electrical signal; and means for producing a signal representative of the concentrating of the Raman active molecule in the ocular aqueous humor from said modulation signal and said Raman electrical signal.
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