[특허]Solid surface coated with a hydrophilic outer layer with covalently bonded biopolymers, a method of making such a surfac

Solid surface coated with a hydrophilic outer layer with covalently bonded biopolymers, a method of making such a surfac 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C08G-069/10 C08H-001/00 C08L-001/00
출원번호	US-0759020 (1991-09-13)
우선권정보	SE-0003363 (1990-10-22)
발명자 / 주소	Bergstrom Karin (Kunglv SEX) Holmberg Krister (Molndal SEX)
출원인 / 주소	Berol Nobel AB (Stenungsund SEX 03)
인용정보	피인용 횟수 : 36 인용 특허 : 0

초록 ▼

A solid surface having anionic groups capable of reacting with imino groups is provided with a hydrophilic outer surface layer comprising a covalently bonded biopolymer by a method selected from the group consisting of: a) reacting a water-soluble conjugate comprising nonionic hydrophilic polymer covalently bonded to a polyethylene imine and at least partly to a biopolymer with anionic groups on the surface; b) reacting a polyethylene imine substituted by nonionic hydrophilic polymer with anionic groups on the surface, and reacting biopolymer with reactive groups of the nonionic hydrophilic polymer in the presence of a reaction medium having a dielectric constant less than 10% of the dielectric constant of pure water; and c) reacting a polyethylene imine substituted by an anionic hydrophilic polymer derived from a nonionic hydrophilic polymer having a cloud point which is at least 5°C. above the temperature at which the final product is to be used, and having biopolymer-reactive groups, and reacting biopolymer forming covalent bonds with reactive groups of the nonionic polymer in a water-base reaction medium at a temperature which is more than 5°C. below the cloud point of the nonionic hydrophilic polymer in the reaction medium. The product comprises a biopolymer immobilized on a hydrophilic solid surface having a hydrophilic layer, coupled thereto via a polyethylene imine, and accordingly has low spontaneous adsorption of proteins and other biopolymers through electrostatic attraction and/or hydrophobic interaction.

대표청구항 ▼

A process for preparing an immobilized biopolymer immobilized on a solid surface and useful in biochemical application, comprising a reaction stage selected from the group consisting of a) reacting a water-soluble conjugate comprising nonionic hydrophilic polymer covalently bonded to a polyethylene imine and at least partly to a biopolymer, with anionic groups on the surface; b) reacting a polyethylene imine substituted by nonionic hydrophilic polymer with anionic groups on the surface, and reacting biopolymer is caused to react with reactive groups of the nonionic hydrophilic polymer in the presence of a reaction medium having a dielectric constant less than 10% of the dielectric constant of pure water; and c) reacting a polyethylene imine substituted by an anionic hydrophilic polymer derived from a nonionic hydrophilic polymer having a cloud point which is at least 5°C. above the temperature at which the immobilized biopolymer is to be used, and having biopolymer-reactive groups, and reacting biopolymer forming covalent bonds with reactive groups of the nonionic polymer in a water-base reaction medium at a temperature which is more than 5°C. below the cloud point of the nonionic hydrophilic polymer in the reaction medium; thereby forming a hydrophilic outer surface layer comprising a covalently bonded biopolymer and comprising nonionic polymer.

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Solid surface coated with a hydrophilic outer layer with covalently bonded biopolymers, a method of making such a surfac 원문보기

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