초록 ▼

A transdermal delivery device has a reservoir containing an active compound, which is kept separate from the delivery layers of the device until administration. At the time of administration, the reservoir is laminated to the delivery layers, or is ruptured to place the active compound, vehicle, and

A transdermal delivery device has a reservoir containing an active compound, which is kept separate from the delivery layers of the device until administration. At the time of administration, the reservoir is laminated to the delivery layers, or is ruptured to place the active compound, vehicle, and/or permeation enhancers in contact with the delivery layers, which results in administration of the active compound to the skin after a delay period.

대표청구항 ▼

A device for administering an active compound transdermally to a subject\s skin, having a delayed onset of delivery, said device consisting essentially of: a first layer comprising a polymeric matrix impregnated with said active compound, said compound and matrix being selected to obtain a first com

A device for administering an active compound transdermally to a subject\s skin, having a delayed onset of delivery, said device consisting essentially of: a first layer comprising a polymeric matrix impregnated with said active compound, said compound and matrix being selected to obtain a first compound diffusion coefficient of about 10-5 to about 10-10 cm2/sec in said matrix; A second layer laminated to said first layer and underlying said first layer, comprising an adhesive capable of adhering to said first layer and to said subject\s skin, said second layer being permeable to the active compound in the absence of an activator, said compound having a second diffusion coefficient of about 10-5 to about 10-10 cm2/sec in said second layer; wherein said second layer is substantially devoid of said active compound at the time said device is applied to said subject\s skin and the administration of active compound to the skin is delayed for the time it takes the active compound to diffuse from the first layer through the second layer to the skin.