[특허]Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin

Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/16 A61K-009/58 A61K-009/10
출원번호	US-0634500 (1990-12-27)
발명자 / 주소	Chang Nienyuan J. (Irvine CA)
출원인 / 주소	Allergan, Inc. (Irvine CA 02)
인용정보	피인용 횟수 : 50 인용 특허 : 0

초록 ▼

Sustained release pharmaceutical compound delivery compositions and methods for their production are disclosed wherein ion exchange resin particles are loaded with releasably bound pharmaceutical compounds prior to incorporation in an erodible polymeric matrix to form microparticulates. The microparticulates are suspended in a fluid medium where the encapsulating polymeric matrix shields the drug loaded ion exchange resin from solvent interaction. Administration to a target tissue site initiations erosion of the polymer matrix and release of the loaded pharmaceutical compound.

대표청구항 ▼

A sustained release pharmaceutical compound delivery composition having improved delivery characteristics and enhance long-term storage stability, said composition comprising: a non-ionic liquid suspension of microparticulates, said microparticulates formed of an erodible bioadhesive polymeric matrix of poly and polyvinylpyrrolidone wherein the ratio of poly (methylvinylether/maleic anhydride) to polyvinylpyrrolidone ranges from approximately 1:1 to 4:1 by weight, incorporating at least one ion exchange resin particle sized from approximately 1 m100 m2 to 50 wt % of a pharmaceutical compound releasably bound thereto.

이 특허를 인용한 특허 (50)

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Tu, Yu-Hsing; Perumal, Ashok; Kathala, Kalyan, Methylphenidate extended release chewable tablet.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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Mehta, Ketan; Tu, Yu-Hsing, Modified release formulations containing drug-ion exchange resin complexes.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
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연합인증

Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin 원문보기

초록 ▼

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연합인증

Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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