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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0879060 (1992-04-30) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 273 인용 특허 : 0 |
The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive el
The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample. The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal. The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.
An iontophoretic diffusion cell device for in vitro non-invasive removal of a charged or uncharged substance from the upper surface of a thin membrane sample, said device comprising a first component and a second component wherein: (1) the first component itself comprises (a) a positive electrode ha
An iontophoretic diffusion cell device for in vitro non-invasive removal of a charged or uncharged substance from the upper surface of a thin membrane sample, said device comprising a first component and a second component wherein: (1) the first component itself comprises (a) a positive electrode having an electrode surface which contacts the upper surface of the membrane sample for collecting a charged or uncharged substance from the thin membrane sample, (b) a negative electrode having an electrode surface which contacts a different portion of the upper surface of the membrane sample for collecting a charged or uncharged substance from the thin membrane sample, and (c) electrical insulation means between the positive electrode and the negative electrode for electrically isolating the positive electrode and the negative electrode from each other and for investigating the membrane continuity or leakage between the positive electrode and the negative electrode, (d) electrically insulating material of construction providing walls to physically separate the positive electrode, the negative electrode and electrically insulating means from each other, and (2) the second component, which is in a complementary detachable sealing relationship with the edges of the electrically insulating material of construction walls of the first component, which second component itself comprises (a) positive liquid reservoir means for contacting the lower surface of the membrane sample, (b) negative liquid reservoir means for contacting a different portion of the lower surface of the membrane sample, (c) electrically insulating and isolating means located immediately between the positive reservoir and negative reservoir, in contact with the lower surface of the thin membrane sample, and (d) electrically insulating material of construction providing walls and an open chamber for electrolyte, wherein in the first component the positive electrode, the negative electrode, and electrical insulation means are configured to present a common surface of wall edges to contact the upper surface of the thin membrane sample, and in the second component, the positive reservoir means, negative reservoir means, electrical insulation means and electrically insulating material of construction together present a complementary matching surface of wall edges to the lower surface of the thin membrane sample, and the positive reservoir and negative reservoir means are continuous as a liquid reservoir to contain a liquid electrolyte to complete the electrical circuit.
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