[특허]Simultaneous multiple assays

Simultaneous multiple assays 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-015/02
출원번호	US-0883574 (1992-05-15)
발명자 / 주소	Hansen W. Peter (New York NY)
출원인 / 주소	Sienna Biotech, Inc. (New York NY 02)
인용정보	피인용 횟수 : 42 인용 특허 : 0

초록 ▼

A particle agglutination-based, stable kinetic method for simultaneously determining the concentrations of multiple analytes in a single fluid sample with the addition of a single reagent, that entails the use of a novel high resolution sheath flow cell, a novel optical flow particle analyzer (FPA), and unidirectional low angle forward light scattering from multiply-sized or refractive indexed, differently coated particles and their aggregates. Also disclosed are two embodiments of an instrument specifically designed to carry out the method of the invention.

대표청구항 ▼

An optical flow particle analyzer for simultaneous assay of multiple analytes in a single fluid sample by a rate-based particle aggregating method, comprising: a) a light source; b) an optically-defined viewing zone upon which viewing zone focused light from said light source is incident; c) means for flowing through said viewing zone a reaction mixture comprising said single fluid sample and a reagent comprising, for each of said multiple analytes, monomeric coated particles of a diameter or refractive index unique for each said analyte, such that each said particle of unique diameter or refractive index or aggregate thereof produces a pulse signal from unidirectional low angle forward light scatter that is distinguishable optically from a pulse signal from unidirectional low angle forward light scatter produced by any other monomeric coated particle of unique diameter or refractive index or aggregate thereof wherein each said unique coated particle is coated with a unique composition that corresponds and binds specifically to a corresponding analyte so as to form aggregating coated particle-analyte binding pairs, so that unique monomeric coated particles or aggregated multimers formed therefrom flowing through said viewing zone produce discrete pulses of scattered light unique for each said unique coated particle-analyte binding pair or aggregated multimer thereof; d) lens means for collecting said pulses of unidirectional low angle forward scattered light; e) single light detector means for receiving collected pulses of said unidirectional low angle forward scattered light and converting said collected pulses into electrical pulse signals, each of said pulse signals being unique for each said coated particle monomer or each said aggregated multimer corresponding to different analytes; f) analyzer means for separating said electrical pulse signals into separate output signals, each of said separate output signals representative of a different analyte, wherein said analyzer means comprises a plurality of single channel analyzers, each of said single channel analyzers being dedicated to each said coated particle monomer of unique diameter or refractive index, or aggregated multimer thereof, each of said unique monomers or multimers thereof corresponding to each of said multiple analytes, such that each of said single channel analyzers monitors the pulse signals from each of said coated monomeric particles of unique diameter or refractive index, or aggregated multimers thereof, and such that each said dedicated single channel analyzer passes as output signals, signals falling within predetermined ranges of signal values, said ranges differing for each subset of said unique coated monomeric particles or aggregated multimers thereof corresponding to each of said multiple analytes; and g) calculator means for calculating and correlating a rate of arrival of each of said output signals per unit time from said analyzer means with each said analyte.

이 특허를 인용한 특허 (42)

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Kleefstra, Meindert J., Method and apparatus for particle sizing.
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Fulton R. Jerrold, Methods and compositions for flow cytometric determination of DNA sequences.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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이 특허를 인용한 특허 (42)

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