[특허]Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof

Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/14 C08K-005/15
출원번호	US-0903367 (1992-06-24)
발명자 / 주소	Capecchi John T. (Oakdale MN) Heilmann Steven M. (Afton MN) Krepski Larry R. (White Bear Lake MN) Kwon Oh-Seung (Woodbury MN) Olson David B. (May Township County of Washington MN)
출원인 / 주소	Minnesota Mining and Manufacturing Company (St. Paul MN 02)
인용정보	피인용 횟수 : 89 인용 특허 : 0

초록 ▼

Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.

대표청구항 ▼

A mammalian body implant comprising: a hydrogel having azlactone-reactive nucleophilic surfaces, a multi-functional azlactone composition covalently coupled using at least one azlactone moiety to the azlactone-reactive nucleophilic surfaces, and a biologically active material coupled to the multi-functional azlactone composition using at least one azlactone moiety; wherein the mammalian body implant has the formula: [Figure] wherein R1 and R2 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon atoms and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R1 and R2 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, and n is an integer 0 or 1; wherein y is at least one and is the number of azlactone moieties less at least one; wherein R3 is a bridging group capable of covalently connecting a plurality of azlactone moieties; and wherein B is the hydrogel having azlactone-reactive nucleophilic surfaces and A is a residue of a azlactone-reactive nucleophilic group on the surface on the hydrogel, the azlactone-reactive nucleophilic group comprising O, S, or NR4, and wherein R4 is hydrogen or an alkyl group containing from 1 to 4 carbon atoms.

이 특허를 인용한 특허 (89)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof 원문보기

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Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof 원문보기

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