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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0861921 (1992-04-01) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 424 인용 특허 : 0 |
Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish a boundary between the host and the implanted cells. The boundary has a pore size, an ultimate strength, and a metabolic transit value that a
Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish a boundary between the host and the implanted cells. The boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward. The boundary allows the fabrication and clinical use of implant assemblies and methodologies that can carry enough cells to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.
An assembly for embedding in host tissue, where it is exposed to physiological stresses and vascularization by host tissue comprising wall means defining a chamber for holding cells while embedded in host tissue, the wall means including means for forming a porous boundary between host tissue and th
An assembly for embedding in host tissue, where it is exposed to physiological stresses and vascularization by host tissue comprising wall means defining a chamber for holding cells while embedded in host tissue, the wall means including means for forming a porous boundary between host tissue and the cells in the chamber, the porous boundary being characterized by a tensile strength and a pore size sufficient to isolate the implanted cells from an immune response of host tissue in which the chamber is embedded; and a metabolic transit value including a permeability value of greater than about 1.5×10-4 cm/sec. for 125I-labeled insulin as determined by pseudo-steady state diffusion in a diaphragm cell, whereby the wall means sustains a flux of nutrients from host tissue in which the chamber is embedded to the cells in the chamber and waste products from the cells in the chamber to host tissue in which the chamber is embedded in the absence of close vascular structures to thereby sustain viability of the cells in the chamber until vascular structures of host tissue form close to the porous boundary.
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