초록

Oral compositions, such as oral gels, toothpastes and mouthwashes, containing an enzyme, a surfactant, a chelating agent and a fluoride ion source.

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1. A toothpaste composition providing improved oral cleansing properties, comprising: a) a safe and effective amount of surfactant; b) a safe and effective amount of an enzyme; c) a chelating agent comprising from about 0.1% to about 10% citric acid and from about 1% to about 10% of an alkyl me

1. A toothpaste composition providing improved oral cleansing properties, comprising: a) a safe and effective amount of surfactant; b) a safe and effective amount of an enzyme; c) a chelating agent comprising from about 0.1% to about 10% citric acid and from about 1% to about 10% of an alkyl metal citrate; d) a safe and effective amount of a fluoride ion source; e) a safe and effective amount of a silica abrasive; f) a suitable oral carrier; and wherein said toothpaste has a pH ranging from about 4.0 to about 9.0 and further wherein said toothpaste can abate the formation and accumulation of plaque and calculus by reducing plaque to abate subsequent calculus formation through augmented bacterial lysis of plaque-forming bacteria, by weakening of the bacterial cell wall through the binding of calcium found in the cell wall of bacteria, by a chelating agent able to complex calcium without tooth demineralization when the toothpaste is free of calcium ion sources that have the ability to complex with either the chelating agent or fluoride ions. 2. An oral composition according to claim 1 wherein the surfactant is selected from the group consisting of sodium lauroyl sarcosinate, sodium alkyl sulfate, cocoamidopropyl betaine, polysorbate 20 and mixtures thereof. 3. An oral composition according to claim 2 wherein the enzyme is selected from the group consisting of endoglycosidase, papain, dextranase, mutanase and mixtures thereof. 4. An oral composition according to claim 1 wherein the fluoride ion source is selected from the group consisting of sodium fluoride, stannous fluoride, sodium monofluorophosphate, potassium fluoride and mixtures thereof. 5. An oral composition according to claim 4 which further comprises from about 15% to about 70% of a humectant selected from the group consisting of glycerin and sorbitol and mixtures thereof. 6. An oral composition according to claim 5 wherein the surfactant is present at a level from about 0.1% to about 5.0%. 7. An oral composition according to claim 6 wherein the enzyme is present at a level from about 0.002% to about 2.0%. 8. An oral composition according to claim 1 wherein the surfactant is sodium lauroyl sarcosinate, the enzyme is endoglycosidase and the chelating agent is a combination of citric acid and sodium citrate. 9. An oral composition according to claim 1 wherein the surfactant is a combination of sodium lauroyl sarcosinate and cocoamidopropyl betaine, the enzyme is papain and the chelating agent is a combination of citric acid and sodium citrate. 10. An oral composition according to claim 1 wherein the surfactant is a combination of sodium lauroyl sarcosinate and cocoamidopropyl betaine, the enzyme is endoglycosidase and the chelating agent is a combination of citric acid and sodium citrate. 11. An oral composition according to claim 1 wherein the surfactant is a combination of sodium lauroyl sarcosinate, cocoamidopropyl betaine and sodium alkyl sulfate, the enzyme is papain and the chelating agent is a combination of citric acid and sodium citrate. 12. A method of augmenting lysis and weakening of plaque forming bacteria through calcium binding of calcium found in the cell wall of bacteria and thereby reducing and preventing plaque and gingivitis, comprising the application of a safe and effective amount of a composition according to claim 1, to the teeth and other oral surfaces. 13. A method of augmenting lysis and weakening of plaque forming bacteria through calcium binding of calcium found in the cell wall of bacteria and thereby reducing and preventing plaque and gingivitis, comprising the application of a safe and effective amount of a composition according to claim 6, to the teeth and other oral surfaces. 14. A method of augmenting lysis and weakening of plaque forming bacteria through calcium binding of calcium found in the cell wall of bacteria and thereby reducing and preventing plaque and gingivitis, comprising the application of a safe and effective amount of a composition according to claim 8, to the teeth and other oral surfaces. 15. A method of augmenting lysis and weakening of plaque forming bacteria through calcium binding of calcium found in the cell wall of bacteria and thereby reducing and preventing plaque and gingivitis, comprising the application of a safe and effective amount of a composition according to claim 11 to the teeth and other oral surfaces. 16. A method of augmenting lysis and weakening of plaque forming bacteria through calcium binding of calcium found in the cell wall of bacteria and thereby reducing and preventing plaque and gingivitis, comprising the application of a safe and effective amount of a composition according to claim 1 to the teeth and other oral surfaces wherein the composition is allowed to remain on the teeth and other oral surfaces for from about 15 seconds to about 12 hours. 17. A method of augmenting lysis and weakening of plaque forming bacteria through calcium binding of calcium found in the cell wall of bacteria and thereby reducing and preventing plaque and gingivitis, comprising the application of a safe and effective amount of a composition according to claim 6 to the teeth and other oral surfaces wherein the composition is allowed to remain on the teeth and other oral surfaces for from about 15 seconds to about 12 hours. 18. A method of augmenting lysis and weakening of plaque forming bacteria through calcium binding of calcium found in the cell wall of bacteria and thereby reducing and preventing plaque and gingivitis comprising the application of a safe and effective amount of a composition according to claim 8 to the teeth and other oral surfaces wherein the composition is allowed to remain on the teeth and other oral surfaces for from about 15 seconds to about 12 hours.