[특허]Apparatus for multiple simultaneous synthesis

[미국특허] Apparatus for multiple simultaneous synthesis 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C08F-283/00
출원번호	US-0012557 (1993-02-02)
발명자 / 주소	Cody Donna R. (Saline MI) DeWitt Sheila H. H. (Dexter MI) Hodges John C. (Ann Arbor MI) Kiely John S. (Ann Arbor MI) Moos Walter H. (Oakland CA) Pavia Michael R. (Newton MA) Roth Bruce D. (Ann Arbor
출원인 / 주소	Warner-Lambert Company (Morris Plains NJ 02)
인용정보	피인용 횟수 : 243 인용 특허 : 0

초록 ▼

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.

대표청구항 ▼

An apparatus for multiple, simultaneous synthesis of compounds comprising: a plurality of reaction tubes, each reaction tube having an upper end and a lower end, said lower end of each reaction tube comprising a filter, said upper end and said filter each having an inside diameter and an outside diameter; a reservoir block having at least one reaction well for receiving said lower end of each reaction tube comprising the filter; a holder block with a plurality of apertures, said apertures having a diameter at least equal to the outside diameter of at least one of said plurality of reaction tubes; a manifold located adjacent to said holder block, said manifold enclosing the upper ends of said plurality of reaction tubes; a means for providing a seal between said holder block and said reservoir block; a means for providing a seal between said holder block and said manifold; and a means for fastening together independently said reservoir block to said holder block and said holder block to said manifold.

이 특허를 인용한 특허 (243) 인용/피인용 타임라인 분석

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James E. Stanchfield ; Paul B. Robbins ; Chris N. Bailey ; David J. Wright, Multi-well apparatus with independently detachable upper and lower covers.
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James E. Stanchfield ; David J. Wright ; Chris N. Bailey ; Paul B. Robbins, Multi-well array with adjustable plenum.
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McLuen Gary R. ; Hanney Richard J. ; Hugens Daniel W., Multi-well rotary synthesizer.
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McLuen, Gary R.; Hanney, Richard J.; Hugens, Daniel W., Multi-well rotary synthesizer.
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McLuen, Gary R.; Hanney, Richard J.; Hugens, Daniel W., Multi-well rotary synthesizer.
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McLuen, Gary R.; Hanney, Richard J.; Hugens, Daniel W., Multi-well rotary synthesizer.
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McLuen, Gary R.; Hanney, Richard J.; Hugens, Daniel W., Multi-well rotary synthesizer.
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McLuen, Gary R.; Hanney, Richard J.; Hugens, Daniel W., Multi-well rotary synthesizer.
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McLuen,Gary R.; Hanney,Richard J.; Hugens,Daniel W., Multi-well rotary synthesizer.
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McLuen,Gary R.; Hanney,Richard J.; Hugens,Daniel W., Multi-well rotary synthesizer.
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Akporiaye, Duncan; Dahl, Ivar Martin; Karlsson, Arne; Wendelbo, Rune, Multiautoclave for combinatorial synthesis of zeolites and other materials.
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Dale R. Pfost ; Sheila H. DeWitt ; Chao Lin ; Rolf E. Swenson ; Robert D. Juncosa ; Gary J. Schnerr ; Sheldon M. Kugelmass, Multiple fluid sample processor and system.
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Rolf E. Swenson, Multiple fluid sample processor with single well addressability.
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Carlson, Eric D.; Cong, Peijun; Chandler, Jr., William H.; Desrosiers, Peter J.; Freitag, J. Christopher; Varni, John F., Needle assembly.
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Weller ; III Harold Norris ; Ruediger Waldemar ; Lawrence R. Michael, Nestable, modular apparatus for synthesis of multiple organic compounds.
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Cook Phillip Dan ; An Haoyun ; Guinosso Charles J. ; Kung Pei-Pei ; Fraser Allister S., Nitrogenous macrocyclic compounds.
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Nomoto, Tsuyoshi; Watanabe, Kohei; Miyazaki, Takeshi; Tanaka, Toshio; Shimada, Yasuhito, Object-holding sheet, test method and object-treating equipment.
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Hebert, Normand, Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same.
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Diamond, Gary M.; Hall, Keith A.; McWaid, Thomas Harding; Murphy, Vince; Myslovaty, Michael; Shoemaker, James A. W.; Sidhu, Robbie Singh; Turner, Howard; Dias, Eric; Spitkovsky, Mikhail, Parallel batch reactor with pressure monitoring.
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Guan Shenheng ; Van Erden Lynn ; Haushalter Robert C. ; Zhou Xiao Ping ; Wang Xuejun Jason ; Srinivasan Ravi, Parallel fixed bed reactor and fluid contacting apparatus.
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Bergh,H. Sam; Engstrom,James R.; Guan,Shenheng; Pinkas,Daniel Meron; Self,Kyle W., Parallel flow process optimization reactor.
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Willson, III, Richard C., Parallel flow reactor and apparatus for testing catalysts.
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Bergh,H. Sam; Guan,Shenheng; Engstrom,James R.; Hardt,Steffen; Lohf,Astrid; Michel,Frank, Parallel flow reactor having improved thermal control.
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Bergh,H. Sam; Engstrom,James R.; Guan,Shenheng; Pinkas,Daniel Meron; Self,Kyle W., Parallel flow reactor having variable composition.
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Turner Howard W. ; Dales G. Cameron ; VanErden Lynn ; van Beek Johannes A. M.,BEX, Parallel reactor with internal sensing.
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Dales, G. Cameron; van Beek, Johannes A. M.; Hajduk, Damian A.; Nielsen, Ralph B.; Mansky, Paul, Parallel reactor with internal sensing and method of using same.
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Howard Turner ; G. Cameron Dales ; Lynn VanErden ; Johannes A. M. VanBeek ; Damian A. Hajduk ; Ralph B. Nielsen ; Paul Mansky ; Leonid Matsiev ; Pei Wang ; Eric McFarland, Parallel reactor with internal sensing and method of using same.
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Turner, Howard; Dales, G. Cameron; VanErden, Lynn; Van Beek, Johannes A. M.; Hajduk, Damian A.; Nielsen, Ralph B.; Mansky, Paul; Matsiev, Leonid; Wang, Pei; McFarland, Eric, Parallel reactor with internal sensing and method of using same.
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Turner, Howard; Dales, G. Cameron; VanErden, Lynn; Van Beek, Johannes A. M.; Hajduk, Damian A.; Nielsen, Ralph B.; Rust, William C., Parallel reactor with internal sensing and method of using same.
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Turner, Howard; Dales, G. Cameron; VanErden, Lynn; VanBeek, Johannes A. M.; Hajduk, Damian A.; Nielsen, Ralph B.; Mansky, Paul; Matsiev, Leonid; Wang, Pei; McFarland, Eric, Parallel reactor with internal sensing and method of using same.
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Turner, Howard; Dales, G. Cameron; VanErden, Lynn; VanBeek, Johannes A. M.; Hajduk, Damian A.; Nielsen, Ralph B.; Rust, William C., Parallel reactor with internal sensing and method of using same.
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Zhou,Xiao Ping; Bergh,Sam; Dube,Christopher E.; Van Erden,Lynn, Parallel reactor with knife-edge seal.
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Safir,Adam; Nielsen,Ralph; McWaid,Thomas H.; Tiede,Richard; Van Erden,Lynn, Parallel semicontinuous or continuous reactors.
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Zanzucchi Peter J. (Lawrenceville NJ) Cherukuri Satyam C. (Cranbury NJ) McBride Sterling E. (Lawrenceville NJ), Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis.
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Zanzucchi Peter John ; Cherukuri Satyam Choudary ; McBride Sterling Edward ; Judd Amrit Kaur, Partitioned microelectronic device array.
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Nielsen,Peter; Buchardt,Ole; Sonnechsen,Soren Holst; Lohse,Jesper; Egholm,Michael; Manoharan,Muthiah; Kiely,John; Griffith,Michael; Sprankle,Kelly, Peptide nucleic acid conjugates.
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Michael Egholm ; Peter Nielsen DK; Ole Buchardt DK; Kim L. Dueholm DK; Leif Christensen DK; James M. Coull ; John Kiely ; Michael Griffith, Peptide nucleic acids.
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Ng, Howard P.; McGee, Danny P. C.; Wu, Guoxian; Moore, Jimmie; Li, Zhi-Hong; Gangwar, Sanjeev; Saunders, Oliver L.; Astafieva, Irina, Peptidyl prodrugs and linkers and stabilizers useful therefor.
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Ng,Howard P.; McGee,Danny P. C.; Wu,Guoxian; Moore,Jimmie; Li,Zhi Hong; Gangwar,Sanjeev; Saunders,Oliver L.; Astafieva,Irina, Peptidyl prodrugs and linkers and stabilizers useful therefor.
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DeWitt Sheila H., Phase separation filter device.
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Schultz, Peter G.; Xiang, Xiao-Dong; Goldwasser, Isy; Briceño, Gabriel; Sun, Xiao-Dong, Polymer arrays from the combinatorial synthesis of novel materials.
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Saxinger,Carl, Polypeptides comprising IL-6 ligand binding receptor domains.
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Saxinger, Carl, Polypeptides comprising IL-6 ligand-binding receptor domains.
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Schultz,Peter G.; Xiang,Xiaodong; Goldwasser,Isy; Brice{hacek over (n)}o,Gabriel; Sun,Xiao Dong; Wang,Kai An, Preparation and screening of crystalline inorganic materials.
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Schultz, Peter G.; Xiang, Xiaodong; Goldwasser, Isy; Briceno, Gabriel; Sun, Xiao-Dong; Wang, Kai-An, Preparation and screening of crystalline zeolite and hydrothermally-synthesized materials.
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Gallup David A. ; Harness James R. ; Haidle Rudy H. ; Grzybowski Andrew J. ; Markus Larry W., Pressurized reaction block.
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Willson, III, Richard C., Process for testing catalysts using chromatography.
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Willson, III, Richard C., Process for testing catalysts using detection agents.
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Willson, III, Richard C., Process for testing catalysts using mass spectroscopy.
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Willson, III, Richard C., Process for testing catalysts using spectroscopy.
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Willson, III, Richard C., Process for testing catalysts using thermography.
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Pei Yazhong ; Kiely John S., Quinoline derivatives and quinoline combinatorial libraries.
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McGowan David Craig ; Mankarios Erik T. ; Manley Edward M. ; Werner Christopher C., Reaction block and cover.
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Cargill John ; Maiefski Romaine R., Reaction block docking station.
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Kedar Haim, Reaction vessel agitation apparatus.
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Niermeyer,J Karl; Laverdiere,Marc; Stankowski,Ralph J.; Smith,Joseph, Receptor for a separation module.
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Michael P. Nova ; Andrew E. Senyei, Remotely programmable matrices with memories.
상세보기
Nova Michael P. ; Senyei Andrew E., Remotely programmable matrices with memories.
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Nova Michael P. ; Senyei Andrew E. ; David Gary S., Remotely programmable matrices with memories.
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Nova Michael P. ; Senyei Andrew E. ; Parandoosh Zahra ; David Gary S., Remotely programmable matrices with memories and uses thereof.
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Waldman, Scott A., ST receptor binding compounds and methods of using the same.
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Jaleh Abedi, Sample preparation for high throughput purification.
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Oberbeck,Sebastian; Schwalbe,Thomas; Autze,Volker; Poelderl,Klaus, Scalable continuous production system.
상세보기
Schultz, Peter G.; Xiang, Xiaodong; Goldwasser, Isy, Screening combinatorial arrays of inorganic materials with spectroscopy or microscopy.
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Niermeyer,J Karl; Laverdiere,Marc; Stankowski,Ralph J.; Smith,Joseph, Separation module.
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Cawse,James Norman, Sequential high throughput screening method and system.
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Schwalbe,Thomas; Golbig,Klaus; Hohmann,Michael; Oberbeck,Andreas; Taghavi Moghadam,Shahriyar, Sequential reaction system.
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Sidhu, Robbie Singh, Small-scale reactor having improved mixing.
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Lawrence Joseph Wilson ; David Edward Portlock ; Min Li, Solid phase synthesis of 1-aminohydantoins.
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Herpin,Timothy F.; Morton,George C.; Salvino,Joseph M, Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives.
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Eadie James Scott, Solid phase synthesizer.
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Nova Michael P. ; Senyei Andrew E. ; Xiao Xiao-Yi ; Zhao Chanfeng ; Potash Hanan, Solid support matrices with memories and combinatorial libraries therefrom.
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Cook P. Dan ; An Haoyun, Substituted heterocyclic compounds.
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Goldberg, Martin J; Diggelman, Martin; Hubbell, Earl A.; McGall, Glenn H.; Ngo, Nam Quoc; Morris, MacDonald; Yamamoto, Melvin; Tan, Jennifer; Rava, Richard P., Substrate preparation process.
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DeWitt Sheila Helen ; Ramage Robert,GBX ; MacDonald Alasdair Arthur, Support for synthesis and purification of compounds.
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DeWitt, Sheila Helen; Ramage, Robert; MacDonald, Alasdair Arthur, Support for synthesis and purification of compounds.
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Schultz, Peter G.; Xiang, Xiaodong; Goldwasser, Isy, Synthesis and screening combinatorial arrays of zeolites.
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Dower William J. (Menlo Park CA) Barrett Ronald W. (Sunnyvale CA) Gallop Mark A. (Palo Alto CA) Needels Michael C. (Oakland CA), Synthesizing and screening molecular diversity.
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Buchardt, Ole; Buchardt, D.; Egholm, Michael; Nielsen, Peter Eigil; Berg, Rolf Henrik, Synthetic procedures for peptide nucleic acids.
상세보기
Schwalbe,Thomas Jochen; Autze,Volker; Oberbeck,Sebastian; Kursawe,Ansgar; Sahin,Kemal H체nkar, System and method for determining optimal reaction parameters using continuously running process.
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Campbell David A. ; Antonenko Valery V. ; Selick Harold E., System and method for solid-phase parallel synthesis of a combinatorial collection of compounds.
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Campbell David A. ; Antonenko Valery V. ; Selick Harold E. ; Gavin Robert M. ; Ida Satoru ; Muir Arthur H., System and method for solid-phase parallel synthesis of a combinatorial collection of compounds.
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Feilders, George; Bostani, Ali; Ross, Art; Waterbury, Raymond; Ma, Guobin, System and method for uniform microwave heating.
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Antonenko Valery V. ; Kulikov Nicolay V. ; Jacobs Jeffrey W., System and methods for parallel synthesis of organic compounds.
상세보기
Demmitt, Thomas J., System for controlling and optimizing reactions in solid phase synthesis of small molecules.
상세보기
Antonenko Valery V. ; Kulikov Nicolay V. ; Jacobs Jeffrey W., System for parallel synthesis of organic compounds.
상세보기
Goldberg, Martin J.; Diggelman, Martin; Hubbell, Earl A.; McGall, Glenn H.; Nam, Ngo; Morris, MacDonald S.; Yamamoto, Melvin; Tan, Jennifer; Rava, Richard, System for photolithographic synthesis of polymer arrays.
상세보기
Kedar Haim ; Brown ; Jr. Albert William, Systems and methods for handling and manipulating multi-well plates.
상세보기
Antonenko Valery V. ; Kulikov Nicolay, Systems and methods for the synthesis of organic compounds.
상세보기
Lang, Hengyuan; Pei, Yazhong, Tetracyclic benzimidazole derivatives and combinatorial libraries thereof.
상세보기
Baum, Stephen A., Three-dimensional array of supports for solid-phase parallel synthesis and method of use.
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Basu, Amaresh; Gahman, Timothy C.; Girten, Beverly E.; Griffith, Michael C.; Hecht, Curtis C.; Kiely, John S.; Slivka, Sandra R., Treatment of erectile dysfunction using isoquinoline compound melanocortin receptor ligands.
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Ming Qi ; R. Normand Hebert ; Alan R. Katritzky, Triazole compounds and methods of making same.
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Waldman, Scott A.; Pitari, Giovanni Mario; Park, Jason; Schulz, Stephanie; Wolfe, Henry R.; Lubbe, Wilhelm, Use of GCC ligands.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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