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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
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| 출원번호 | US-0907518 (1992-07-02) |
| 발명자 / 주소 |
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| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 320 인용 특허 : 0 |
Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthetic hydrophil
Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living (preferably human) being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.
A biocompatible, biologically inactive conjugate comprising an inert, naturally occurring biocompatible polymer or derivative thereof chemically conjugated to a synthetic non-immunogenic hydrophilic polyethylene glycol polymer.
A biocompatible, biologically inactive conjugate comprising an inert, naturally occurring biocompatible polymer or derivative thereof chemically conjugated to a synthetic non-immunogenic hydrophilic polyethylene glycol polymer.
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