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Hepatitis C virus protease 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/00
출원번호 US-0680296 (1991-04-04)
발명자 / 주소
  • Houghton Michael (Danville CA) Choo Qui-Lim (El Cerrito CA) Kuo George (San Francisco CA)
출원인 / 주소
  • Chiron Corporation (Emeryville CA 02)
인용정보 피인용 횟수 : 50  인용 특허 : 0

초록

The protease necessary for polyprotein processing in Hepatitis C virus is identified, cloned, and expressed. Proteases, truncated protease, and altered proteases are disclosed which are useful for cleavage of specific polypeptides, and for assay and design of antiviral agents specific for HCV.

대표청구항

An isolated polynucleotide which encodes only the HCV protease or an active HCV protease analog.

이 특허를 인용한 특허 (50)

  1. Sardana Vinod V. ; Blue Jeffrey T., Detergent-free hepatitis C protease.
  2. Charles Moen Rice, III ; Alexander A. Kolykhalov, Functional DNA clone for hepatitis C virus (HCV) and uses thereof.
  3. Rice Charles M. ; Kolykhalov Alexander A., Functional DNA clone for hepatitis C virus (HCV) and uses thereof.
  4. Rice,Charles M.; Kolykhalov,Alexander A., Functional DNA clone for hepatitis C virus (HCV) and uses thereof.
  5. Wands,Jack; Encke,Jens, Genetic immunization with nonstructural proteins of hepatitis C virus.
  6. Houghton Michael ; Choo Qui-Lim ; Han Jang ; Choe Joonho,KRX, HCV NS3 protein fragments having helicase activity and improved solubility.
  7. Houghton Michael ; Choo Qui-Lim ; Han Jang ; Choe Joonho,KRX, HCV NS3 protein fragments having helicase activity and improved solubility.
  8. Houghton,Michael; Choo,Qui Lim; Han,Jang; Choe,Joonho, HCV NS3 protein fragments having helicase activity and improved solubility.
  9. Michael Houghton ; Qui-Lim Choo ; Jang Han ; Joonho Choe KR, HCV NS3 protein fragments having helicase activity and improved solubility.
  10. Coit, Doris; Medina-Selby, Angelica; Selby, Mark; Houghton, Michael, HCV non-structural polypeptide.
  11. Chien,David; Coit,Doris; Hu,Celine; Lin,Sansan; Medina Selby,Angelica, HCV non-structural protein mutants and uses thereof.
  12. Rice, III,Charles M.; Blight,Keril J., HCV variants.
  13. Rice, III,Charles M.; Blight,Keril J., HCV variants.
  14. Rice,Charles M.; Blight,Keril J., HCV variants.
  15. Sallberg, Matti, Hepatitis C virus codon optimized non-structural NS3/4A fusion gene.
  16. Sallberg, Matti, Hepatitis C virus codon optimized non-structural NS3/4A fusion gene.
  17. Sallberg, Matti, Hepatitis C virus codon optimized non-structural NS3/4A fusion gene.
  18. Sallberg, Matti, Hepatitis C virus codon optimized non-structural NS3/4A fusion gene.
  19. Sallberg,Matti, Hepatitis C virus codon optimized non-structural NS3/4A fusion gene.
  20. Sallberg,Matti, Hepatitis C virus codon optimized non-structural NS3/4A fusion gene.
  21. Sallberg,Matti, Hepatitis C virus codon optimized non-structural NS3/4A fusion gene.
  22. S?llberg, Matti, Hepatitis C virus non-structural NS3/4A fusion gene.
  23. Sällberg, Matti, Hepatitis C virus non-structural NS3/4A fusion gene.
  24. S?llberg,Matti, Hepatitis C virus non-structural NS3/4A fusion gene.
  25. S��llberg,Matti, Hepatitis C virus non-structural NS3/4A fusion gene.
  26. Houghton Michael (Danville CA) Choo Qui-Lim (El Cerrito CA) Kuo George (San Francisco CA), Hepatitis C virus protease.
  27. Houghton Michael (Danville CA) Choo Qui-Lim (El Cerrito CA) Kuo George (San Francisco CA), Hepatitis C virus protease.
  28. Houghton Michael ; Choo Qui-Lim ; Kuo George, Hepatitis C virus protease.
  29. Houghton Michael ; Choo Qui-Lim ; Kuo George, Hepatitis C virus protease.
  30. Sällberg, Matti; Soderholm, Jonas; Frelin, Lars, Immunogen platform.
  31. Sällberg, Matti; Soderholm, Jonas; Frelin, Lars, Immunogen platform.
  32. Coit,Doris; Medina Selby,Angelica; Selby,Mark; Houghton,Michael, Immunogenic Hepatitis C virus non-structural polypeptides.
  33. Wittekind Michael ; Weinheimer Steven ; Zhang Yaqun ; Goldfarb Valentina, Modified forms of Hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease: inhibitor complexes.
  34. Wittekind, Michael; Weinheimer, Steven; Zhang, Yagun; Goldfarb, Valentina, Modified forms of hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease:inhibitor complexes.
  35. Chien David Y., NANBV diagnostics and vaccines.
  36. David Y. Chien, NANBV diagnostics and vaccines.
  37. Coit,Doris; Medina Selby,Angelica; Selby,Mark; Houghton,Michael, Polynucleotide encoding novel HCV non-structural polypeptide.
  38. Seidel Christoph,DEX ; Wienhues Ursula-Henrike,DEX ; Schmitt Urban,DEX ; Motz Manfred,DEX ; Wiedmann Michael,DEX ; Upmeier Barbara,DEX ; Soutschek Erwin,DEX, Recombinant antigen from the NS3 region of the hepatitis C virus.
  39. Seidel Christoph,DEX ; Wienhues Ursula-Henrike,DEX ; Schmitt Urban,DEX ; Motz Manfred,DEX ; Wiedmann Michael,DEX ; Upmeier Barbara,DEX ; Soutschek Erwin,DEX, Recombinant antigen from the NS3 region of the hepatitis C virus.
  40. Seidel Christoph,DEX ; Wienhues Ursula-Henrike,DEX ; Schmitt Urban,DEX ; Motz Manfred,DEX ; Wiedmann Michael,DEX ; Upmeier Barbara,DEX ; Soutschek Erwin,DEX, Recombinant antigen from the NS3 region of the hepatitis C virus.
  41. Potts Karen Elizabeth ; Jackson Roberta Lynn ; Patick Amy Karen, Reporter gene system for use in cell-based assessment of inhibitors of the Hepatitis C virus protease.
  42. Potts, Karen Elizabeth; Jackson, Roberta Lynn; Patick, Amy Karen, Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease.
  43. Potts, Karen Elizabeth; Jackson, Roberta Lynn; Patick, Amy Karen, Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease.
  44. Zhang Rumin ; Mui Philip W. ; Weber Patricia C., Synthetic inhibitors of hepatitis C virus NS3 protease.
  45. S?llberg, Matti; Hultgren, Catharina, Vaccines containing ribavirin and methods of use thereof.
  46. Sallberg, Matti; Hultgren, Catharina, Vaccines containing ribavirin and methods of use thereof.
  47. S채llberg,Matti; Hultgren,Catharina, Vaccines containing ribavirin and methods of use thereof.
  48. S?llberg,Matti; Hultgren,Catharina, Vaccines containing ribavirin and methods of use thereof.
  49. S?llberg,Matti; Hultgren,Catharina, Vaccines containing ribavirin and methods of use thereof.
  50. S?llberg,Matti; Hultgren,Catharina, Vaccines containing ribavirin and methods of use thereof.
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