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Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biologic 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08K-005/22
  • A01N-033/26
  • A61K-031/785
  • C08F-008/30
출원번호 US-0935565 (1992-08-24)
발명자 / 주소
  • Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD)
출원인 / 주소
  • The United States of America as represented by the Secretary of Health and Human Services (Washington DC 06)
인용정보 피인용 횟수 : 138  인용 특허 : 0

초록

A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N2O2-functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is b

대표청구항

A polymer capable of releasing nitric oxide, said polymer comprising a polymeric backbone, wherein said polymeric backbone is of a polymer selected from the group consisting of a polyolefin, a polyether, a polyester, a polyamide, a polyurethane, a peptide, and a starburst dendrimer, and at least one

이 특허를 인용한 특허 (138)

  1. Shami, Paul J.; Kosack, Ken M., Activated nitric oxide donors and methods of making and using thereof.
  2. Shami, Paul J.; Kosak, Ken M., Activated nitric oxide donors and methods of making and using thereof.
  3. McDonald, William F.; Huang, Zhi-Heng; Wright, Stacy C., Antimicrobial polymer.
  4. McDonald, William F.; Wright, Stacy C.; Taylor, Andrew C., Antimicrobial polymer.
  5. Fossel, Eric T., Beneficial effects of increasing local blood flow.
  6. Santerre, Paul J., Bioactive surface modifiers for polymers and articles made therefrom.
  7. Hossainy,Syed F A; Michal,Eugene T; Claude,Charles D., Biocompatible carrier containing L-arginine.
  8. Saavedra Joseph E. (Thurmont MD) Keefer Larry K. (Bethesda MD) Roller Peter P. (Rockville MD) Akamatsu Miki (Rockville MD), Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of trea.
  9. Saavedra Joseph E. ; Keefer Larry K. ; Roller Peter P. ; Akamatsu Miki, Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same.
  10. Starling, L. Brian; Stephan, James E., Calcium-containing structures and methods of making and using the same.
  11. Starling, L. Brian; Stephan, James E., Calcium-containing structures and methods of making and using the same.
  12. Daniel J. Smith ; Sibel Yazici TR, Chitosan-based nitric oxide donor compositions.
  13. Hossainy,Syed F. A., Coatings containing polycationic peptides for cardiovascular therapy.
  14. Shah,Ashok A.; Michal,Eugene T., Coatings for implantable medical device containing polycationic peptides.
  15. Michal,Eugene T; Hossainy,Syed F A; Consigny,Paul M, Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine.
  16. Rothbard, Jonathan B.; McGrane, Paul L.; Engleman, Edgar G.; Fathman, C. Garrison; Kreider, Erik, Compositions and methods for treating diseases.
  17. Hunter, William L.; Machan, Lindsay S., Compositions and methods for treating or preventing diseases of body passageways.
  18. Hyde, Roderick A.; Ishikawa, Muriel Y.; Wood, Jr., Lowell L., Condoms configured to facilitate release of nitric oxide.
  19. McDonald,William F.; Koren,Amy B.; Dourado,Sunil K.; Dulebohn,Joel I.; Hanchar,Robert J., Conductive polymer-based material.
  20. Peters, Tor, Cosmetic treatment with nitric oxide, device for performing said treatment and manufacturing method therefor.
  21. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  22. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  23. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  24. Hyde, Roderick A.; Ishikawa, Muriel Y.; Stordal, Leif T.; Wood, Jr., Lowell L., Devices and systems that deliver nitric oxide.
  25. Hyde, Roderick A.; Ishikawa, Muriel Y.; Stordal, Leif T.; Wood, Jr., Lowell L., Devices and systems that deliver nitric oxide.
  26. Chen, Mingfei; Shumaker, David; Cheng, Peiwen; Udipi, Kishore, Diazeniumdiolated phosphorylcholine polymers for nitric oxide release.
  27. Chen, Mingfei; Cheng, Peiwen; Udipi, Kishore, Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices.
  28. Fitzhugh, Anthony L.; Cafferata, Robert; Keefer, Larry K., Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use.
  29. Fitzhugh,Anthony L.; Cafferata,Robert; Keefer,Larry K., Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use.
  30. Cheng, Peiwen; Chen, Mingfei; Udipi, Kishore, Hindered amine nitric oxide donating polymers for coating medical devices.
  31. Smith Daniel J. ; Rao Weisun, Hydrolytically unstable, biocompatible polymer.
  32. Claude,Charles D.; Michal,Eugene T., Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine.
  33. Michal, Eugene T.; Claude, Charles D., Implantable medical devices incorporating plasma polymerized film layers and charged amino acids.
  34. Shami, Paul, In vivo use of glutathione S-transferase activated nitric oxide donors.
  35. Cooke John P. ; Schwarzacher Sverin ; Lim Tai T.,SGX ; Yeung Alan C., Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury.
  36. Stamler Jonathan ; Loscalzo Joseph ; Folts John D., Localized use of nitric oxide adducts to prevent internal tissue damage.
  37. Jonathan S. Stamler ; Joseph Loscalzo ; John D. Folts, Localized use of nitric oxide-adducts to prevent internal tissue damage.
  38. Jonathan S. Stamler ; Joseph Loscalzo ; John D. Folts, Localized use of nitric oxide-adducts to prevent internal tissue damage.
  39. Stamler Jonathan ; Loscalzo Joseph ; Folts John D., Localized use of nitric oxide-adducts to prevent internal tissue damage.
  40. Tedeschi Eugene ; Shah Chirag B., Lubricious, drug-accommodating coating.
  41. Stamler Jonathan S. ; Griffith Owen W., Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses.
  42. Stamler, Jonathan S.; Griffith, Owen W., Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses.
  43. Stamler,Jonathan S.; Griffith,Owen W., Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses.
  44. Stamler Jonathan S. ; Griffith Owen W., Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically, proliferating cells or to upregulate nitrosative stress defenses.
  45. Jonathan S. Stamler ; Owen W. Griffith, Manipulating nitrosative stress to upregulate nitrosative stress defenses.
  46. Herzog, Jr., William R.; Pou, Sovitj; Rosen, Gerald M.; Zhao, Yi-Ju, Medical device coated with a polymer containing a nitric oxide releasing organometallic nitrosyl compound useful for the prevention of platelet aggregation.
  47. Saffran, Bruce N., Medical devices and methods for modulation of physiology using device-based surface chemistry.
  48. Kim, Won Jong; Kim, Jihoon; Lee, Haeshin; Hong, Seonki, Method of preparing coating film containing nitrogen monoxide on surface of material using catecholamine.
  49. Hyde, Roderick A.; Ishikawa, Muriel Y.; Wood, Jr., Lowell L., Methods and systems for use of photolyzable nitric oxide donors.
  50. Hyde, Roderick A.; Ishikawa, Muriel Y.; Wood, Jr., Lowell L., Methods and systems for use of photolyzable nitric oxide donors.
  51. Chen, Mingfei; Cheng, Peiwen; Udipi, Kishore, Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation.
  52. Stamler, Jonathan S., Methods for producing and using S-nitrosohemoglobins.
  53. Stamler Jonathan S., Methods for producing nitrosated hemoglobins and therapeutic uses therefor.
  54. Bauman, Susanne; Stasko, Nathan A., Methods of decreasing sebum production in the skin.
  55. Michal, Eugene T.; Shah, Ashok A.; Ding, Ni, Methods of forming a micronized peptide coated stent.
  56. Michal, Eugene T; Shah, Ashok A; Ding, Ni, Micronized peptide coated stent.
  57. Stamler, Jonathan S.; Gow, Andrew J., Modified hemoglobins, including nitrosylhemoglobins, and uses thereof.
  58. Cheng, Peiwen; Chen, Mingfei; Udipi, Kishore, Nitric oxide donating medical devices and methods of making same.
  59. Hyde, Roderick A.; Ishikawa, Muriel Y.; Wood, Jr., Lowell L., Nitric oxide permeable housings.
  60. Hyde, Roderick A.; Ishikawa, Muriel Y.; Stordal, Leif T.; Wood, Jr., Lowell L., Nitric oxide sensors and systems.
  61. Fine, David H., Nitric oxide therapies.
  62. Fine, David H., Nitric oxide therapies.
  63. Joseph E. Saavedra ; Larry K. Keefer ; Peter P. Roller ; Miki Akamatsu, Nitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising same.
  64. Schoenfisch, Mark; Riccio, Daniel; Nugent, Julia; Stasko, Nathan, Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same.
  65. Chen, Mingfei; Udipi, Kishore; Cheng, Peiwen, Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore.
  66. Hrabie, Joseph A.; Citro, Michael L.; DeRosa, Frank; Keefer, Larry K., Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof.
  67. Hrabie, Joseph A.; DeRosa, Frank; Keefer, Larry K., Nitric oxide-releasing diazeniumdiolated compounds.
  68. Keefer,Larry K.; Hrabie,Joseph A., Nitric oxide-releasing medical devices.
  69. Fitzhugh Anthony L. ; Cheng Peiwen ; Saavedra Joseph ; Cafferata Robert ; Hendriks Marc,NLX ; Keefer Larry K. ; Tedeschi Eugene ; Verhoeven Michel L. P. M.,NLX, Nitric oxide-releasing metallic medical devices.
  70. Fitzhugh, Anthony L.; Cheng, Peiwen; Saavedra, Joseph; Cafferata, Robert; Hendriks, Marc; Keefer, Larry K.; Tedeschi, Eugene; Verhoeven, Michel I. P. M., Nitric oxide-releasing metallic medical devices.
  71. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
  72. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
  73. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
  74. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
  75. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
  76. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing polymers.
  77. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing polymers.
  78. Stamler, Jonathan S.; Gow, Andrew J., No-modified hemoglobins and uses therefor.
  79. Stamler, Jonathan S., No-modified hemoglobins and uses therefore.
  80. Saavedra,Joseph E; Keefer,Larry K, O-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1, 2-diolates.
  81. Saavedra, Joseph E.; Keefer, Larry K.; Srinivasan, Aloka; Rice, William G.; Ji, Xinhua; Bogdan, Christian, O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates.
  82. Saavedra, Joseph E.; Keefer, Larry K.; Srinivasan, Aloka; Bogdan, Christian; Rice, William G.; Ji, Xinhua, O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates.
  83. Shah Chirag B. ; Tedeschi Eugene, One step lubricious coating.
  84. Kaesemeyer,Wayne H., Pharmaceutical composition comprising citrulline.
  85. Pacetti, Stephen D.; Michal, Eugene T.; Hossainy, Syed F. A.; Ding, Ni; Roorda, Wouter E., Polycationic peptide coatings and methods of coating implantable medical devices.
  86. Pacetti, Stephen D.; Michal, Eugene T.; Hossainy, Syed F. A.; Ding, Ni; Roorda, Wouter E., Polycationic peptide coatings and methods of coating implantable medical devices.
  87. Pacetti,Stephen D.; Michal,Eugene T; Hossainy,Syed F A; Ding,Ni; Roorda,Wouter E, Polycationic peptide coatings and methods of coating implantable medical devices.
  88. Simhambhatla, Murthy V.; Ding, Ni; Pacetti, Stephen D., Polycationic peptide coatings and methods of making the same.
  89. Simhambhatla,Murthy V; Ding,Ni; Pacetti,Stephen D., Polycationic peptide coatings and methods of making the same.
  90. Hossainy, Syed F. A., Polycationic peptide hydrogel coatings for cardiovascular therapy.
  91. Keefer Larry K. ; Hrabie Joseph A., Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods o.
  92. Trescony Paul ; Rohly Ken ; Dror Michael, Polymeric material that releases nitric oxide.
  93. Jonathan S. Stamler ; Eric J. Toone ; Richard S. Stack, Polymers for delivering nitric oxide in vivo.
  94. Stamler Jonathan S. ; Toone Eric J. ; Stack Richard S., Polymers for delivering nitric oxide in vivo.
  95. Stamler Jonathan S. ; Toone Eric J. ; Stack Richard S., Polymers for delivering nitric oxide in vivo.
  96. Stamler, Jonathan S.; Toone, Eric J.; Stack, Richard S., Polymers for delivering nitric oxide in vivo.
  97. Stamler, Jonathan S.; Toone, Eric J.; Stack, Richard S., Polymers for delivering nitric oxide in vivo.
  98. Stamler,Jonathan S.; Toone,Eric J.; Stack,Richard S., Polymers for delivering nitric oxide in vivo.
  99. Stamler,Jonathan S.; Toone,Eric J.; Stack,Richard S., Polymers for delivering nitric oxide in vivo.
  100. Smith Daniel J. (Stow OH) Chakravarthy Debashish (Garrettsville OH) Keefer Larry K. (Bethesda MD), Polysaccharide-bound nitric oxide-nucleophile adducts.
  101. Stamler Jonathan S. ; Bonaventura Joseph, Red blood cells loaded with S-nitrosothiol and uses therefor.
  102. Stamler Jonathan S. ; Bonaventura Joseph, Red blood cells loaded with S-nitrosothiol and uses therefor.
  103. Stamler, Jonathan S.; Bonaventura, Joseph; Pawloski, John R.; McMahon, Timothy J., Red blood cells loaded with S-nitrosothiol and uses therefor.
  104. Murrell George Anthony Calvert, Regulation of wound healing by nitric oxide.
  105. Reneker, Darrell H.; Smith, Daniel J., Sequestered reactive materials.
  106. Hyde, Roderick A.; Ishikawa, Muriel Y.; Stordal, Leif T.; Wood, Jr., Lowell L., Substrates for nitric oxide releasing devices.
  107. Hyde, Roderick A.; Ishikawa, Muriel Y.; Stordal, Leif T.; Wood, Jr., Lowell L., Substrates for nitric oxide releasing devices.
  108. Lemelson Jerome, System and method for treating cellular disorders in a living being.
  109. Hyde, Roderick A.; Ishikawa, Muriel Y.; Wood, Jr., Lowell L., Systems and devices that utilize photolyzable nitric oxide donors.
  110. Fossel, Eric T., Systems and methods for treatment of allergies and other indications.
  111. Schoenfisch, Mark; Riccio, Daniel, Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same.
  112. Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
  113. Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
  114. Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
  115. Fossel, Eric T., Topical composition containing ibuprofen.
  116. Fossel, Eric T., Topical composition containing naproxen.
  117. Doxey, Ryan; Bao, Jian, Topical compositions and methods of using the same.
  118. Doxey, Ryan; Bao, Jian, Topical compositions and methods of using the same.
  119. Doxey, Ryan; Sabouni, Adam; Kougoulos, Eleftherios; Stasko, Nathan, Topical compositions and methods of using the same.
  120. Doxey, Ryan; Sabouni, Adam; Kougoulos, Eleftherios; Stasko, Nathan, Topical compositions and methods of using the same.
  121. Fossel, Eric T., Topical delivery of L-arginine to cause beneficial effects.
  122. Fossel, Eric T., Topical delivery of L-arginine to cause beneficial effects.
  123. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Topical gels and methods of using the same.
  124. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Topical gels and methods of using the same.
  125. Fossel, Eric Thor, Transdermal delivery of beneficial substances effected by a hostile biophysical environment.
  126. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  127. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  128. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  129. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  130. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  131. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  132. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  133. McDonald, William F.; Koren, Amy B., Two dimensional polymer that generates nitric oxide.
  134. Keefer Larry K. ; Saavedra Joseph E. ; Doherty Paul C. ; Hanamoto Mark S. ; Place Virgil A., Use of nitric oxide-releasing agents to treat impotency.
  135. Keefer Larry K. ; Saavedra Joseph E. ; Doherty Paul C. ; Hanamoto Mark S. ; Place Virgil A., Use of nitric oxide-releasing agents to treat impotency.
  136. Tedeschi, Eugene; Shah, Chirag B., Uses for medical devices having a lubricious, nitric oxide-releasing coating.
  137. Igo Stephen R. ; Meador James W., Vascular treatment method and apparatus.
  138. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Wound dressings, methods of using the same and methods of forming the same.
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