[특허]Liquid chromatography column adapted for in situ chemical sterilization

Liquid chromatography column adapted for in situ chemical sterilization 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01D-015/08
출원번호	US-0251847 (1994-05-31)
발명자 / 주소	Jungbauer Alois (Vienna ATX) Lettner Hans P. (Vienna ATX)
출원인 / 주소	BioSepra Inc. (Marlborough MA 02)
인용정보	피인용 횟수 : 55 인용 특허 : 0

초록 ▼

A liquid chromatography column well-suited for in situ sterilization effected by washing with a sterilization solution. In a preferred embodiment, the column comprises a liquid chromatography tube packed with a liquid chromatography resin. A piston assembly is mounted within the liquid chromatography tube towards the upper end thereof, the piston assembly including an upper portion and a lower portion, the lower portion being shaped to include a fluid distribution channel and a downwardly-extending collar, the downwardly-extending collar including an annular slot and defining an orifice in fluid communication with the fluid distribution channel. The column further includes a distributor for distributing fluid conducted through the fluid distribution channel over the entirety of the orifice, the distributor being positioned over the liquid chromatography resin and a corrugated expanding ring for mounting the distributor within the orifice, the corrugated expanding ring being mounted in the annular slot and serving to support the distributor. Preferably, the distributor is a metal plate, either in the form of a multilayer sintered metal filter, a perforated plate with a hole diameter less than the lower grain diameter of the resin particles, or a woven and/or sintered stainless steel monolayer welded onto a metal ring.

대표청구항 ▼

A liquid chromatography column comprising: (a) a liquid chromatography tube packed with a liquid chromatography resin; (b) a piston assembly mounted within said liquid chromatography tube towards the upper end thereof, said piston assembly including an upper portion and a lower portion, said lower portion being shaped to include a fluid distribution channel and a downwardly-extending collar, said downwardly-extending collar including an annular slot and defining an orifice in fluid communication with said fluid distribution channel; (c) a distributor disposed within said orifice for distributing fluid conducted through said fluid distribution channel over the entirety of said orifice, said distributor being positioned over said liquid chromatography resin; and (d) means for mounting said distributor within said orifice, said mounting means comprising a corrugated expanding ring mounted in said annular slot, said corrugated expanding ring supporting said distributor.

이 특허를 인용한 특허 (55)

Leavesley Peter J. ; Van Davelaar Peter C. ; Lockman Robert D., Apparatus and method for making a sealable connection to a chromatography cartridge.
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Van Davelaar Peter C., Apparatus and method for making a sealable connection to a chromatography cartridge.
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Shalon Yehuda ; Nykin Ilya B. ; Shalon Tadmor, Apparatus that maintains compression in a tube.
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Shalon,Yehuda; Laub,Charles F., Chromatographic device having an elongate rod and method of forming and chromatographic device.
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Shalon Yehuda ; Meyer Danny ; Li Y. Andrew, Chromatographic device with piston locking mechanism and method of packing same.
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Leavesley, Peter J.; Van Davelaar, Peter C.; Lockman, Robert D.; Hargro, Ivan; Horsman, Jeffrey A.; Rahn, Peter C., Chromatography apparatus.
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Paananen,Hannu; Heikkil채,Heikki; Lewandowski,Jari; Varteva,Esko, Distributing or collecting device.
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Niazi, Sarfaraz K., Downstream bioprocessing device.
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Niazi, Sarfaraz Khan, Downstream bioprocessing device.
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Salven, Owe; Gebauer, Klaus; Bellqvist, Peter; Davis, John; Pichl, Ulf, Endpiece for a chromatography column.
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Thompson, Jonathan; Gerner, Yuri; Sims, Carl W., Filter apparatus.
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Gebauer, Klaus; Georgescu, Mircea, Filter holder in a chromatography column.
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Titus, Michael; Noyes, Aaron; Rayner, Ian; Antoniou, Chris, High velocity chromatography column flow distributor.
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Rightnour,Bradley R.; Goss,Michael A.; Silvis,Paul H.; Cox,Christopher S., Inlet double-seal assembly.
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Konstantinov, Konstantin; Godawat, Rahul; Warikoo, Veena; Jain, Sujit, Integrated continuous manufacturing of therapeutic protein drug substances.
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Konstantinov, Konstantin; Godawat, Rahul; Warikoo, Veena; Jain, Sujit, Integrated continuous manufacturing of therapeutic protein drug substances.
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Konstantinov, Konstantin; Godawat, Rahul; Warikoo, Veena; Jain, Sujit, Integrated continuous manufacturing of therapeutic protein drug substances.
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Minamoto, Norimasa; Ito, Masahito; Deguchi, Kisaburo; Tanai, Hiroyuki; Mori, Kiyotoshi, Liquid chromatograph, liquid chromatograph column and filter for liquid chromatograph column.
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Conroy Christine M. ; Green Jeffrey R. ; Kaster Jeffrey A. ; Leavesley Peter J. ; Ransohoff Thomas C., Liquid chromatography column.
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Klepp, Georg-Heinrich; Böcker, Sebastian; Strube, Jochen; Kansy, Heinz; Schmale, Hendrik, Liquid distributor and liquid collector for chromatography columns.
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Shalon Yehuda ; Nykin Ilya B. ; Shalon Tadmor, Method for packing and sealing chromatographic columns.
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Gebauer, Klaus, Packing system and method for chromatography columns.
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Gebauer, Klaus, Packing system and method for chromatography columns.
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Rund, Derek Berton; Davis, Dennis Lee, Protective bottle sling.
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Marcus, Pamela Wong; Joy, Daren Edward, Protective sleeves for containers.
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Mann William H., Slurry fill method and valve.
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Mann, William H., Slurry fill method and valve.
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Godawat, Rahul; Warikoo, Veena; Patil, Rohan; Konstantinov, Konstantin; Ryakala, Venkat Kishore, Sterile affinity chromatography resin.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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연합인증

Liquid chromatography column adapted for in situ chemical sterilization 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허를 인용한 특허 (55)

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연합인증

Liquid chromatography column adapted for in situ chemical sterilization 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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이 특허를 인용한 특허 (55)

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특허 원문 보기

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