[특허]Determination of ambient concentation of several analytes

Determination of ambient concentation of several analytes 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/543 G01N-033/537 G01N-033/533
출원번호	US-0984264 (1992-12-01)
우선권정보	GB-0003000 (1988-02-10)
발명자 / 주소	Ekins Roger P. (London GB3)
출원인 / 주소	Multilyte Limited (GBX 03)
인용정보	피인용 횟수 : 63 인용 특허 : 0

초록 ▼

A method for determining the ambient concentrations of a plurality of analytes in a liquid sample of volume V liters, comprises loading a plurality of different binding agents, each being capable of binding specifically and reversibly an analyte of interest onto a support means at a plurality of spaced apart locations such that not more than 0.1 V/K moles of each binding agent are present at any location, where k liters/mole is the equilibrium constant of each such binding agent; contracting the loaded support means with the sample to be analyzed, such that each of the spaced apart locations is contacted in the same operation with the sample, the amount of sample liquid being such that only an insignificant proportion of any analyte present in the sample becomes bound to the binding agent specific for it, and measuring a parameter representative of the fractional occupancy by the analytes of the binding agents at the spaced apart locations by a competitive or non-competitive assay technique, using a labelled site-recognition reagent for each binding agent capable of recognizing either the unfilled binding sites or the filled binding sites on the binding agent, which enables the amount of said reagent in the particular location to be measured. A device and kit for use in the method are also provided.

대표청구항 ▼

A method for determining the ambient concentrations of a plurality of analytes in a liquid sample of volume V liters, comprising: loading a plurality of different binding agents, each being capable of reversibly binding an analyte which is or may be present in the liquid sample and is specific for said analyte as compared to the other components of the liquid sample, onto a support means at a plurality of spaced apart small spots such that each spot has a high coating density of one of said binding agents but not more than 0.1 V/K moles of binding agent are present on any spot, where K liters/mole is the affinity constant of said binding agent for said analyte; contacting the loaded support means with the liquid sample to be analyzed, such that each of the spots is contacted in the same step with said liquid sample, the amount of liquid used in said sample being such that only an insignificant proportion of any analyte present in said liquid sample becomes bound to said binding agent specific for said analyte, and measuring a parameter representative of the fractional occupancy by said analytes of said binding agents at the spots by a competitive or non-competitive assay technique using a site-recognition reagent for each binding agent capable of recognizing either the unfilled binding sites or the filled binding sites on said binding agent, said site-recognition reagent being labelled with a marker enabling the amount of said reagent in the particular location to be measured.

이 특허를 인용한 특허 (63)

Stephen P. A. Fodor ; Dennis W. Solas ; William J. Dower, Analysis of target molecules using an encoding system.
상세보기
Yguerabide Juan ; Yguerabide Evangelina E. ; Kohne David E. ; Jackson Jeffrey T., Analyte assay using particulate labels.
상세보기
Yguerabide, Juan; Yguerabide, Evangelina E.; Kohne, David E.; Jackson, Jeffrey T., Analyte assay using particulate labels.
상세보기
Schick, Eginhard; Utinger, Dominic; Calonder, Claudio, Apparatus and method for coating substrates for analyte detection by means of an affinity assay method.
상세보기
Fodor, Stephen P. A.; Stryer, Lubert; Pirrung, Michael C.; Read, J. Leighton; Hoeprich, Jr., Paul D., Apparatus comprising polymers.
상세보기
Stryer, Luburt; Fodor, Stephen P. A.; Read, J. Leighton; Pirrung, Michael C., Apparatus for polymer synthesis.
상세보기
Lamont, John Victor; McConnell, Robert Ivan; Fitzgerald, Stephen Peter, Array imaging method.
상세보기
Grunert, Veit Peter; Klause, Ursula; Kubalec, Pavel; Rothfuss, Matthias; Upmeier, Barbara, Assay for measurement of antibodies binding to a therapeutic monoclonal antibody.
상세보기
Ekins Roger P.,GB3 ITX RH5 GJR, Back-titration assay using two different markers.
상세보기
Ekins Roger P.,GB3 ITX RH5 GJR, Binding assay.
상세보기
Winkler, James L.; Fodor, Stephen P. A.; Buchko, Christopher J.; Ross, Debra A.; Aldwin, Lois; Modlin, Douglas N., Combinatorial strategies for polymer synthesis.
상세보기
Winkler, James L.; Fodor, Stephen P. A.; Buchko, Christopher J.; Ross, Debra A.; Aldwin, Lois; Modlin, Douglas N., Combinatorial strategies for polymer synthesis.
상세보기
Winkler, James L.; Fodor, Stephen P. A.; Buchko, Christopher J.; Ross, Debra A.; Aldwin, Lois; Modlin, Douglas N., Combinatorial strategies for polymer synthesis.
상세보기
Winkler, James L.; Fodor, Stephen P. A.; Buchko, Christopher J.; Ross, Debra A.; Aldwin, Lois; Modlin, Douglas N., Combinatorial strategies for polymer synthesis.
상세보기
Dias, Peter; Singh, Sujay, Compositions and methods for improved detection and classification of neoplasms.
상세보기
Braesch-Andersen, Sten; Paulie, Staffan, Cultispot assay.
상세보기
Obremski,Robert J.; Silzel,John W.; Tsay,Tsong Tseh; Cercek,Bibijana; Dodson,Charles L.; Wang,Tung Rung; Liu,Yagang; Shaomin,Zhou, Detection of very low quantities of analyte bound to a solid phase.
상세보기
Abel, Andreas Peter; Duveneck, Gert Ludwig; Ehrat, Markus; Kresbach, Gerhard Matthias; Pawlak, Michael; Schürmann-Mader, Eveline, Device and method for determining multiple analytes.
상세보기
Tchaga, Grigoriy S., Highly sensitive proteomic analysis methods, and kits and systems for practicing the same.
상세보기
Tchaga,Grigoriy S., Highly sensitive proteomic analysis methods, and kits and systems for practicing the same.
상세보기
Klause, Ursula; Lenz, Helmut; Markert-Hahn, Christine, Immune complex-specific antibodies for increased sensitivity in immunoassay array tests.
상세보기
Zuk, Robert F.; Tan, Hong, Immunoassay cuvettes.
상세보기
Zuk, Robert F.; Tan, Hong, Immunoassay cuvettes.
상세보기
James P. Mapes, Indirect label assay device for detecting small molecules and method of use thereof.
상세보기
Mapes James P., Indirect label assay device for detecting small molecules and method of use thereof.
상세보기
Pawlak,Michael; Schick,Eginhard; Abel,Andreas Peter; Duveneck,Gert Ludwig; Ehrat,Markus; Kresbach,Gerhard Matthias; Sch��rmann Mader,Eveline; Bopp,Martin Andreas, Kit and method for determining a plurality of analytes.
상세보기
Pawlak, Michael; Schick, Eginhard; Abel, Andreas Peter; Duveneck, Gert Ludwig; Ehrat, Markus; Kresbach, Gerhard Matthias; Schürmann-Mader, Eveline; Bopp, Martin Andreas, Kit and method for multi-analyte determination.
상세보기
Stephen Peter Fitzgerald GB; John Victor Lamont GB; Robert Ivan McConnell GB; El Ouard Benchikh GB, Method for making a device for the simultaneous detection of multiple analytes.
상세보기
Fodor, Stephen P. A.; Solas, Dennis W.; Dower, William J., Method of comparing nucleic acid sequences.
상세보기
Lim, Mark J.; Rothschild, Kenneth J., Methods and compositions for phototransfer.
상세보기
Lim, Mark J; Rothschild, Kenneth J, Methods and compositions for phototransfer.
상세보기
Zhou, Fang X.; Schweitzer, Barry, Methods for conducting assays for enzyme activity on protein microarrays.
상세보기
Shalon, Tidhar Dari; Brown, Patrick O., Methods for constructing subarrays and subarrays made thereby.
상세보기
Stryer, Lubert; Fodor, Stephen P. A.; Read, J. Leighton; Pirrung, Michael C., Methods for polymer synthesis.
상세보기
Yguerabide,Juan; Yguerabide,Evangelina; Warden,Laurence; Peterson,Todd, Methods for providing extended dynamic range in analyte assays.
상세보기
Stryer, Lubert; Pirrung, Michael C.; Read, J. Leighton; Fodor, Stephen P. A., Methods of synthesizing a plurality of different polymers on a surface of a substrate.
상세보기
Hoeffler, James P.; Fernandez, Joseph M.; Nasoff, Marc S., Microarray and uses therefor.
상세보기
Hoeffler, James P.; Fernandez, Joseph M.; Nasoff, Marc S., Microarrays and uses therefor.
상세보기
Hoeffler, James; Fernandez, Joseph; Nasoff, Marc, Microarrays and uses therefor.
상세보기
Wohlstadter, Jacob N.; Wilbur, James L.; Sigal, George B.; Martin, Mark T.; Guo, Liang-Hong; Fischer, Alan; Leland, Jon; Billadeau, Mark A., Multi-array, multi-specific electrochemiluminescence testing.
상세보기
Heil, James R.; Schneider, Daniel J.; Nieuwlandt, Daniel T.; Wilcox, Sheri K.; Zichi, Dominic; Gander, Todd; Eaton, Bruce; Gold, Larry, Multiplexed analyses of test samples.
상세보기
Schneider, Daniel J.; Nieuwlandt, Dan; Eaton, Bruce; Stanton, Martin; Gupta, Shashi; Kraemer, Stephan; Zichi, Dominic; Gold, Larry, Multiplexed analyses of test samples.
상세보기
Schneider, Daniel J.; Nieuwlandt, Dan; Eaton, Bruce; Stanton, Marty; Gupta, Shashi; Kraemer, Stephan; Zichi, Dominic; Gold, Larry, Multiplexed analyses of test samples.
상세보기
Paulie, Staffan; Braesch-Andersen, Sten, Non-elispot assay.
상세보기
Gold Larry ; Drolet Dan ; Zichi Dom ; Jayasena Sumedha ; Creighton Steve ; Gill Stanley, Nucleic acid ligand diagnostic Biochip.
상세보기
Gold, Larry; Drolet, Dan; Zichi, Dom; Jayasena, Sumedha; Creighton, Steve; Gill, Stanley, Nucleic acid ligand diagnostic biochip.
상세보기
Gold, Larry; Drolet, Daniel; Zichi, Dominic A.; Jayasena, Sumedha; Creighton, Steve; Gill, Stanley, Nucleic acid ligand diagnostic biochip.
상세보기
Gold, Larry; Zichi, Dominic, Nucleic acid ligand diagnostic biochip.
상세보기
Larry Gold ; Dan Drolet ; Dom Zichi ; Sumedha Jayasena ; Steve Creighton ; Stanley Gill, Nucleic acid ligand diagnostic biochip.
상세보기
Pirrung, Michael C.; Read, J. Leighton; Fodor, Stephen P. A.; Stryer, Lubert, Nucleic acid reading and analysis system.
상세보기
Stephen P. A. Fodor ; J. Leighton Read ; Lubert Stryer ; Michael C. Pirrung, Nucleic acid reading and analysis system.
상세보기
Fodor,Stephen P. A.; Stryer,Lubert; Read,J. Leighton; Pirrung,Michael C., Nucleotides and analogs having photoremovable protecting groups.
상세보기
Michael C. Pirrung ; Lubert Stryer ; Stephen P. A. Fodor ; J. Leighton Read, Photolithographic and other means for manufacturing arrays.
상세보기
Stephen P. A. Fodor ; J. Leighton Read ; Lubert Stryer ; Michael C. Pirrung, Photolithographic and other means for manufacturing arrays.
상세보기
Fodor, Stephen P. A.; Read, J. Leighton; Stryer, Lubert; Pirrung, Michael C., Polypeptide arrays.
상세보기
Stephen P. A. Fodor ; Dennis W. Solas ; William J. Dower, Products for detecting nucleic acids.
상세보기
Snyder, Michael; Reed, Mark; Zhu, Heng; Klemic, James Frank, Protein chips for high throughput screening of protein activity.
상세보기
Brown,Patrick O.; Shalon,Tidhar Dari, Substrates comprising polynucleotide microarrays.
상세보기
Fodor, Stephen P. A.; Pirrung, Michael C.; Stryer, Lubert; Read, J. Leighton, Support bound probes and methods of analysis using the same.
상세보기
J. Leighton Read ; Stephen P. A. Fodor ; Lubert Stryer ; Michael C. Pirrung, Support bound probes and methods of analysis using the same.
상세보기
Stephen P.A. Fodor ; James L. Winkler, System for determining receptor-ligand binding affinity.
상세보기
Karl, Johann; Lenz, Helmut; Krause, Friedemann; Finckh, Peter; Hornauer, Hans; Berger, Johann, Use of check surfaces for identifying disturbing samples in a detection procedure.
상세보기
Fodor, Stephen P. A.; Stryer, Lubert; Read, J. Leighton; Pirrung, Michael C., Very large scale immobilized polymer synthesis.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Determination of ambient concentation of several analytes 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허를 인용한 특허 (63)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Determination of ambient concentation of several analytes 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허를 인용한 특허 (63)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트