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Stable porfimer sodium compositions and methods for their manufacture 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/40
출원번호 US-0075227 (1993-06-10)
발명자 / 주소
  • Clauss Steven L. (Manville NJ) Pastel Michael J. (Highland Mills NY) Zawadzki Rainer K. (Wuhan CNX)
출원인 / 주소
  • American Cyanamid Company (Stamford CT 02)
인용정보 피인용 횟수 : 105  인용 특허 : 0

초록

A storage stable porfimer sodium (polyhematoporphyrin ether/ester) composition useful in the photodynamic therapy of cancer and other conditions is provided. The composition is characterized in that the percentage of ester linked porphyrin oligomers is less than 10% of the composition. Improved proc

대표청구항

A porfimer sodium pharmaceutical composition comprised of porphyrin oligomers having ether and ester covalent linkages wherein less than 10% of said linkages in the porphyrin oligomers are ester linkages, said oligomers in association with a pharmaceutically acceptable carrier.

이 특허를 인용한 특허 (105)

  1. Edelman, Jeffrey L.; Hughes, Patrick M.; Malone, Thomas C.; De Vries, Gerald W.; Chang-Lin, Joan-En; Shiah, Jane Guo; Nivaggioli, Thierry; Spada, Lon T.; Blanda, Wendy M., Biodegradable intravitreal tyrosine kinase implants.
  2. Edelman, Jeffrey L.; Hughes, Patrick M.; Malone, Thomas C.; DeVries, Gerald W.; Chang-Lin, Joan-En; Shiah, Jane-Guo; Nivaggioli, Thierry; Spada, Lon T.; Blanda, Wendy M., Biodegradable intravitreal tyrosine kinase implants.
  3. Edelman, Jeffrey L.; Hughes, Patrick M.; Malone, Thomas C.; DeVries, Gerald W.; Chang-Lin, Joan-En; Shiah, Jane-Guo; Nivaggioli, Thierry; Spada, Lon T.; Blanda, Wendy M., Biodegradable intravitreal tyrosine kinase implants.
  4. Chang, James N.; Hughes, Patrick M.; Devries, Gerald W., Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems.
  5. Pandey, Ravindra K.; Grossman, Zachary; Kanter, Peter; Dougherty, Thomas J., Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals.
  6. Pandey, Ravindra K.; Grossman, Zachary; Kanter, Peter; Dougherty, Thomas J., Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals.
  7. Pandey,Ravindra K.; Grossman,Zachary; Kanter,Peter; Dougherty,Thomas J., Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and NSconjugates for MR contrast media and radiopharmaceuticals.
  8. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
  9. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
  10. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
  11. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for administering compartmentalized frozen particles.
  12. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  13. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  14. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  15. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  16. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  17. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for biological remodeling with frozen particle compositions.
  18. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
  19. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
  20. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
  21. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for delivery of frozen particle adhesives.
  22. Hughes, Patrick M.; Olejnik, Orest; Whitcup, Scott M.; Burke, James A., Compositions and methods for localized therapy of the eye.
  23. Trogden, John T.; Salameh, Adnan K.; Pujara, Chetan P., Compositions and methods for stimulating hair growth.
  24. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  25. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  26. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  27. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  28. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  29. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  30. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  31. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
  32. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  33. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  34. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  35. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  36. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  37. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  38. Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
  39. Cantrell, Gary L.; Rajagopalan, Raghavan; Berberich, David W.; Karwa, Amolkumar; Dorshow, Richard B., Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers.
  40. Cantrell, Gary L.; Rajagopalan, Raghavan; Karwa, Amolkumar; Dorshow, Richard B., Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers.
  41. Cantrell, Gary L.; Rajagopalan, Raghavan; Karwa, Amolkumar; Dorshow, Richard B., Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers.
  42. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and array devices thereof.
  43. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
  44. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
  45. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
  46. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
  47. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Frozen compositions and methods for piercing a substrate.
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  56. Hughes, Patrick M., Hypotensive lipid-containing biodegradable intraocular implants and related methods.
  57. Hughes, Patrick M., Hypotensive prostamide-containing biodegradable intraocular implants and related methods.
  58. Hughes, Patrick M.; Sarrazin, Christian; Rossi, Elisabeth; Boix, Michele, Intraocular biodegradable microspheres.
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  60. Hughes, Patrick M., Intraocular pressure reduction with intracameral bimatoprost implants.
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  62. Roberts, Michael Scot, Lighting systems and methods of using lighting systems for in virto potency assay for photofrin.
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  66. Pandey,Ravindra K.; Grossman,Zachary; Kanter,Peter; Dougherty,Thomas J., Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and NSconjugates for MR contrast media and radiopharmaceuticals.
  67. Hughes, Patrick M.; Boix, Michele; Sarrazin, Christian; Do, Marina, Method of making oil-in-oil emulsified polymeric implants containing a hypotensive lipid.
  68. Hughes, Patrick M.; Sarrazin, Christian; Rossi, Elisabeth; Boix, Michèle, Method of making tyrosine kinase microspheres.
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  70. Huang, Glenn T.; Nivaggioli, Thierry; Spada, Lon T.; Sugimoto, Hiroshi; Blanda, Wendy M.; Chang, James N.; Olejnik, Orest, Methods of treating ocular disease using steroid-containing sustained release intraocular implants.
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  72. Hughes, Patrick M.; Boix, Michele; Sarrazin, Christian; Do, Marina, Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and prostamide.
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  78. Lyons, Robert T.; Robinson, Michael R.; Trogden, John T.; Whitcup, Scott M., Peripherally administered viscous formulations.
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  104. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Systems, devices, and methods for making or administering frozen particles.
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