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Stable porfimer sodium compositions and methods for their manufacture

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-031/40   
미국특허분류(USC) 514/410 ; 540/145
출원번호 US-0075227 (1993-06-10)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 105  인용 특허 : 0
초록

A storage stable porfimer sodium (polyhematoporphyrin ether/ester) composition useful in the photodynamic therapy of cancer and other conditions is provided. The composition is characterized in that the percentage of ester linked porphyrin oligomers is less than 10% of the composition. Improved processes for preparing such compositions are also provided wherein acetylated hematoporphyrin is treated with alkali for sufficient time and temperature to reduce the amount of porphyrin oligomers joined by ester linkages to less than 10% of the composition.

대표
청구항

A porfimer sodium pharmaceutical composition comprised of porphyrin oligomers having ether and ester covalent linkages wherein less than 10% of said linkages in the porphyrin oligomers are ester linkages, said oligomers in association with a pharmaceutically acceptable carrier.

이 특허를 인용한 특허 피인용횟수: 105

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