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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0107276 (1993-08-16) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 388 인용 특허 : 0 |
Light developed by an implantable probe is used to illuminate a treatment site that has been perfused with a photoreactive agent. A number of different embodiments of implantable probes are disclosed. Preferably, an array of light emitting diodes (LEDs) or solid-state laser diodes (LDs) are mounted
Light developed by an implantable probe is used to illuminate a treatment site that has been perfused with a photoreactive agent. A number of different embodiments of implantable probes are disclosed. Preferably, an array of light emitting diodes (LEDs) or solid-state laser diodes (LDs) are mounted on a light bar inside the implantable probe and are energized either using a storage battery power source, an inductively coupled external transformer, or with current provided in leads running through a flexible catheter that extends outside the patient\s body to an external source. The implantable probe is normally intended to be disposed inside a patient\s body during a surgical procedure, at a treatment site, and left in place for several days (or longer) after an incision is closed, while light produced by the array of LEDs or solid-state LDs irradiates the treatment site. Alternatively, light from an external light source can be conveyed over one or more optical fibers to an implantable probe that is disposed inside the patient\s body to irradiate the treatment site. Waste heat produced by the array of LEDs or LDs disposed on the implantable probe can be employed to augment the PDT by increasing the temperature of the tissue at the treatment site.
A method for photodynamic treatment at an internal, in vivo treatment site, to cause a desired therapeutic change, comprising the steps of: (a) applying a photoreactive agent to the internal, in vivo treatment site, said photoreactive agent being selected for one or more characteristic wavelengths o
A method for photodynamic treatment at an internal, in vivo treatment site, to cause a desired therapeutic change, comprising the steps of: (a) applying a photoreactive agent to the internal, in vivo treatment site, said photoreactive agent being selected for one or more characteristic wavelengths or wavebands of light absorption; (b) positioning a light source that directly generates light internally within a patient\s body, said light source being transcutaneously delivered to the in vivo treatment site and left implanted within the patient\s body during the photodynamic treatment, the light emitted by the light source having one or more emission wavelengths or wavebands substantially equal to a wavelength or waveband of absorption of the photoreactive agent; and (c) administering the light emitted from the light source to the internal, in vivo treatment site, said light being absorbed by the photoreactive agent, which then causes the desired therapeutic change at the treatment site.
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