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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0204947 (1994-03-02) |
| 발명자 / 주소 |
|
| 인용정보 | 피인용 횟수 : 456 인용 특허 : 0 |
A minimally invasive bioactivated endoprosthesis device for vessel repair. The device comprises a stent which is formed from metal or polymers into a predetermined shape which includes a plurality of holes patterned with a desired size, shape and number to provide a desired bending modulus. The sten
A minimally invasive bioactivated endoprosthesis device for vessel repair. The device comprises a stent which is formed from metal or polymers into a predetermined shape which includes a plurality of holes patterned with a desired size, shape and number to provide a desired bending modulus. The stent is then coated with a polymer or is formed from a polymer which contains a bioactive substance which achieves an equilibrium with the surrounding body tissues or fluids, with the equilibrium being controlled by charge distribution, concentration and molecular weight of the bioactive substance in relation to the pore size of the polymeric carrier for controlled prolonged release of said bioactive substance. The bioactive substance may be selected from the group of heparin, hirudin, prostacyclenes and analogs thereof, antithrombogenic agents, steroids, ibuprofen, antimicrobials, antibiotics, tissue plasma activators, rifamicin, monoclonal antibodies, snake venom protein by-products, antifibrosis agents, cyclosporine and mixtures of these bioactive substances for simultaneous multiple treatments. The stent itself may take several distinct configurations, all of which have a predetermined biasing force acting on the diameter of the stent. Preferred is a rolled stent which is provided with a coiled shape to which it tends to return when expanded. Locking tabs are provided to engage the some of the plurality of holes at the maximum expanded size to prevent return to the smaller diameter coiled shape. Alternatively the predetermined bias of the stent may be the expanded size so that the stent is coiled against this bias during insertion.
A minimally invasive bioactivated endoprosthesis device for vessel repair in contact with surrounding body tissues, comprising: a stent formed from a flat sheet having an appreciable width to thickness to present a substantial surface to said tissues and coiled to a size for use with a blood vessel
A minimally invasive bioactivated endoprosthesis device for vessel repair in contact with surrounding body tissues, comprising: a stent formed from a flat sheet having an appreciable width to thickness to present a substantial surface to said tissues and coiled to a size for use with a blood vessel or other body conduit and including a plurality of holes, said holes being sufficiently large to permit rapid endothelialization, said stent further including at least one tab for cooperative engagement with said holes to form an internally unrestricted stent having a diameter adjusted to a selected size for said blood vessel or other body conduit; and a polymer forming the exterior surface of said stent for operative contact with said tissue, said polymer having a microporous structure with a predetermined pore size and further including a bioactive substance within said pores for elution from said pores, said pore size being selected in response to the concentration and molecular weight of said substance to achieve equilibrium between said polymer and said tissue to provide a controlled and prolonged release of said bioactive substance to said surrounding body tissue in an amount sufficient to substantially prevent hyperplasia or therapeutically treat said tissue, said stent having a sufficient amount of said substantial surface to support a quantity of said polymer capable of prolonged release of said amount.
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