[특허]In vitro chamber for human organ tissue samples

In vitro chamber for human organ tissue samples 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12M-001/00 C12M-001/06 C12M-001/18 C12M-003/00
출원번호	US-0189764 (1994-02-01)
발명자 / 주소	Coble Don (Frederick MD) Prodouz Kristina N. (Bethesda MD)
출원인 / 주소	The Gillette Company (Boston MA 02)
인용정보	피인용 횟수 : 43 인용 특허 : 0

초록 ▼

An in vitro chamber for sustaining organ tissue samples during optical study with, for example a microscope, has a tray assembly with a plurality of wells, each of which may be provided with a clampable sleeve or a vertically adjustable thimble such that an associated organ tissue sample contacts a nutrient medium contained in a reservoir. The tray assembly rests upon a heater assembly having a water-jet-driven magnetic stirrer magnetically coupled with a driven magnetic stirrer in the nutrient reservoir to maintain a substantially uniform temperature in both the heater assembly and the nutrient reservoir. A thermally insulating collar surrounding the tray assembly and the heater assembly maintains relative positions thereof. A transparent cover encloses the top of the tray assembly so that air borne exchanges with the wells and nutrient splashes are substantially contained.

대표청구항 ▼

A chamber for sustaining tissue samples in vitro for optical microscopic examination comprising: a tray assembly including a top portion and a bottom portion, the bottom portion comprising a reservoir chamber for holding nutrient solution, the top portion comprising a well plate having a plurality of wells, each of the wells being adapted to hold a tissue sample and having an opening through the bottom of the well plate, the top portion being removably, but sealingly, mounted to the bottom portion such that the wells are in communication with the reservoir chamber in a manner that allows tissue samples placed in the wells to be contacted by nutrient solution placed in the reservoir chamber; a transparent cover positioned over the top portion of the tray assembly and operable in conjunction therewith to contain gases above the wells and prevent contaminants from passing into or out of the wells; a heater assembly having a top surface with a high heat transfer capacity for supporting the tray assembly in heat transfer relationship therewith and a planar bottom surface for substantially unimpeded placement on a microscope stage, the heater assembly including a tank for containing a temperature regulating fluid, the tank having an inlet conduit and an outlet conduit for circulating the temperature regulating fluid.

이 특허를 인용한 특허 (43)

Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
상세보기
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
상세보기
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
상세보기
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
상세보기
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
상세보기
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
상세보기
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Schein, Douglas; Harris, Stanley; Steibel, Dennis; Fraser, Richard; Isaacs, Dickon, Apparatus and method for maintaining and/or restoring viability of organs.
상세보기
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Schein, Douglas; Isaacs, Dickon, Apparatus and method for maintaining and/or restoring viability of organs.
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Lee Ann A. ; Laib Jessie Carolyn, Biaxial strain system for cultured cells.
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Hung, Ju-Sung Paul; Lee, Philip J.; Cappione, Amedeo J., Cell culture and gradient migration assay methods and devices.
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Hung, Ju-Sung Paul; Lee, Philip J.; Cappione, Amedeo J., Cell culture and gradient migration assay methods and devices.
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Hung, Ju-Sung Paul; Lee, Philip J.; Cappione, III, Amedeo J., Cell culture and gradient migration assay methods and devices.
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Hung, Paul J.; Lee, Philip J., Cell culture and invasion assay method and system.
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Hung, Paul J.; Lee, Philip J., Cell culture array system for automated assays and methods of operation and manufacture.
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Hung, Paul J.; Lee, Philip J., Cell culture array system for automated assays and methods of operation and manufacture thereof.
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Dunfield,John Stephen; Yenchik,Ronni J., Cell culture device.
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Schlosser, Monika, Container for keeping filled bottles cool.
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Bloecker Helmut,DEX ; Kauer Gerhard,DEX, Drying module.
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Aoki, Shigeki; Sakai, Yuichi; Yamashita, Mitsuo; Shinya, Hiroshi, Heat processing apparatus and heat processing method.
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Aoki, Shigeki; Sakai, Yuichi; Yamashita, Mitsuo; Shinya, Hiroshi, Heat processing apparatus and heat processing method.
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Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Method for controlling perfusion of an organ.
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Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J; Fraser, Richard; Harris, Stanley; Schein, Douglas; Curtis, Christopher G., Method of determining transport and/or storage parameters for maintaining viability of an organ.
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Saunders, Dennis L., Method of high throughput haze screening of material.
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Hung, Paul J.; Lee, Philip J.; Lee, Luke P., Methods and apparatus for cell culture array.
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Hung, Paul J.; Lee, Philip J.; Lee, Luke P., Methods and apparatus for cell culture array.
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Lee, Philip J.; Gaige, Terry; Ho, Wei Hsuan (Jessie), Micro-incubation systems for microfluidic cell culture and methods.
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Lee, Philip J.; Gaige, Terry; Ho, Wei Hsuan (Jessie), Micro-incubation systems for microfluidic cell culture and methods.
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Lee, Philip J.; Gaige, Terry; Ho, Wei Hsuan (Jessie), Micro-incubation systems for microfluidic cell culture and methods.
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Hung, Paul J.; Lee, Philip J., Microfluidic cell culture systems.
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Lee, Philip Janmin; Hung, Paul Ju-Sung; Maheshri, Narendra, Microfluidic particle analysis method, device and system.
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Lee, Philip Janmin; Hung, Paul Ju-Sung; Maheshri, Narendra, Microfluidic particle analysis method, device and system.
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Hung, Paul Ju-Sung; Lee, Philip Janmin, Microwell cell-culture device and fabrication method.
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Al-Obeidi, Fahad A. D.; Austin, Richard E., Multi-well plate with perimeteral heat reservoir.
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Domansky, Karel; Griffith, Linda G.; Tannenbaum, Steven R.; Wells, Alan; Inman, Samuel Walker, Perfused three-dimensional cell/tissue disease models.
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Alexandre N. Terentiev, Pumping or mixing system using a levitating magnetic element.
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Terentiev, Alexandre N., Pumping or mixing system using a levitating magnetic element, related system components, and related methods.
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Terentiev, Alexandre N., Set-up kit for a pumping or mixing system using a levitating magnetic element.
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Nozaki, Takayuki; Kan, Kazutoshi, Temperature regulating member.
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Hung, Paul Ju-Sung; Lee, Philip Janmin, Valved, microwell cell-culture device and method.
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Hung, Paul Ju-Sung; Lee, Philip Janmin, Valved, microwell cell-culture device and method.
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Hung, Paul Ju-Sung; Lee, Philip Janmin, Valved, microwell cell-culture device and method.
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Hung, Paul Ju-Sung; Lee, Philip Janmin, Valved, microwell cell-culture device and method.
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Griffith Linda G. ; Tannenbaum Steven ; Powers Mark J. ; Domansky Karel ; Thompson Charles D., Vascularized perfused microtissue/micro-organ arrays.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

In vitro chamber for human organ tissue samples 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허를 인용한 특허 (43)

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연합인증

In vitro chamber for human organ tissue samples 원문보기

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대표청구항 ▼

연구과제 타임라인

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이 특허를 인용한 특허 (43)

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