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[미국특허] Oral liquid alendronate formulations 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/66
  • A61K-031/685
출원번호 US-0245289 (1994-05-17)
발명자 / 주소
  • Brenner Gerald S. (Norristown PA) Katdare Ashok V. (Norristown PA) Pretzer Denise (Chesterfield MO) Whiteford Donna T. (Brooklyn NY)
출원인 / 주소
  • Merck & Co., Inc. (Rahway NJ 02)
인용정보 피인용 횟수 : 40  인용 특허 : 0

초록

Disclosed is a therapy protocol for treating and for preventing bone loss in patients who have difficulty in swallowing by administering a liquid formulation of alendronate which can be easily swallowed. Also described are pharmaceutical dosage forms of a syrup, aqueous solution, a solution formed f

대표청구항

A pharmaceutical composition comprising a pharmaceutically effective amount of alendronate, in a pharmaceutically acceptable carrier and a sufficient amount of a buffer to maintain a pH of the composition in the range of 2 to 8 and complexing agent to prevent the precipitation of alendronate in aque

이 특허를 인용한 특허 (40) 인용/피인용 타임라인 분석

  1. Sanders,John M.; Song,Yongcheng; Chan,Julian M. W.; Oldfield,Eric; Zhang,Yonghui, Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases.
  2. Oldfield, Eric; Song, Yongcheng; Zhang, Yonghui; Sanders, John M., Bisphosphonate compounds and methods.
  3. Sanders, John M.; Song, Yongcheng; Chan, Julian M. W.; Oldfield, Eric; Zhang, Yonghui, Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases.
  4. Oldfield, Eric; Zhang, Yonghui; Yin, Fenglin, Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS.
  5. Remington, Benjamin J.; Bearss, David J.; Shahi, Kavian, Bone growth compositions and methods.
  6. Remington,Benjamin J.; Bearss,David J.; Shahi,Kavian, Bone growth compositions and methods.
  7. Azriel Schmidt ; Shun-Ichi Harada ; Gideon Rodan, Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism.
  8. Maclean David B. ; Thompson David D., Combination therapy to treat osteoporosis-polyphosphonates and estrogen agonists.
  9. Zanetti, Daniel; Cairatti, Damian; Piccinni, Enrique; Roldan, Emilio J. A.; Papapoulos, Socrates, Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof.
  10. Zanetti, Daniel; Cairatti, Damian; Piccinni, Enrique; Roldan, Emilio J. A.; Papapoulos, Socrates, Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof.
  11. Gasper Shirley R. ; West Robert R. ; Martinez Theresa ; Robbins Kirk G. ; McKernan Patricia A. ; Baindur Nand ; Labroo Virender M.,INX ; Mundy Gregory R., Compositions and methods for stimulating bone growth.
  12. Dansereau, Richard John; Burgio, Jr., David Ernest, Dosage forms of bisphosphonates.
  13. Dansereau, Richard John; Burgio, Jr., David Ernest, Dosage forms of bisphosphonates.
  14. Dansereau, Richard John; Burgio, Jr., David Ernest, Dosage forms of bisphosphonates.
  15. Dansereau, Richard John; Burgio, Jr., David Ernest, Dosage forms of risedronate.
  16. Feng-Jing Chen ; Mahesh V. Patel, Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods.
  17. Brenner Gerald S. ; Ghannam Musa M., Intravenous alendronate formulations.
  18. Brenner Gerald S. ; Ghannam Musa M., Intravenous alendronate formulations.
  19. Shirley R. Gasper ; Robert R. West ; Theresa Martinez ; Kirk G. Robbins ; Patricia A. McKernan ; Nand Baindur ; Virender M. Labroo IN; Gregory R. Mundy, Isoprenoid pathway inhibitors for stimulating bone growth.
  20. Zhang, Jack Yongfeng; Luo, Mary Ziping; Fei, Dingyuan; Xie, Kevin; Ding, Jie Fei, Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate.
  21. Dansereau, Richard John; Burgio, Jr., David Ernest, Low dosage forms of risedronate or its salts.
  22. Dansereau, Richard John; Burgio, Jr., David Ernest, Low dosage forms of risedronate or its salts.
  23. Ho, Mei-Ling; Chang, Je-Ken; Eswaramoorthy, Rajalakshmanan; Wu, Shun-Cheng; Wang, Yao-Hsien, Method for bone formation by administering poly(lactic-co-glycolic acid) cross-linked alendronate.
  24. Harvey Colin E. ; Mohn Kenneth L., Method for inhibiting dental resorptive lesions.
  25. Sethi, Vijay; Camper, Clinton B., Method of drying biomass.
  26. Santora ; II Arthur C. ; Karpf David B. ; Polvino William J. ; Shapiro Deborah Ruth ; Thompson Desmond E. ; Yates Ashley John, Method of lessening the risk of non-vertebral bone fractures.
  27. Bauss, Frieder; Pichler, Bernhard; Turley, Stephen, Method of treatment using bisphosphonic acid.
  28. Bauss,Frieder; Pichler,Bernhard; Turley,Stephen, Method of treatment using bisphosphonic acid.
  29. Bauss,Frieder; Pichler,Bernhard; Turley,Stephen, Method of treatment using bisphosphonic acid.
  30. Cronstein, Bruce N.; Kara, Firas Mohamed, Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass.
  31. Pohjala Esko,FIX ; Nupponen Heikki,FIX ; Lauren Leena,FIX ; Hannuniemi Ritva,FIX ; Vepsalainen Jouko,FIX ; Kahkonen Jouni,FIX ; Jarvinen Tomi,FIX ; Ahlmark Marko,FIX, Methylenebisphosphonic acid derivatives.
  32. Camper, Clinton B.; Sethi, Vijay; Isaak, Jerrod D., Post torrefaction biomass pelletization.
  33. Sethi, Vijay; Camper, Clinton B.; Isaak, Jerrod D., Post torrefaction biomass pelletization.
  34. Yates Ashley John ; Karpf David B., Prevention of tooth loss by the administration of alendronate or its salts.
  35. Dunlop, Donald D.; Camper, Clinton B.; Sethi, Vijay; Kenyon, Jr., Leon C., Process for drying coal.
  36. Dunlop, Donald D.; Kenyon, Jr., Leon C., Process for drying coal.
  37. Dunlop, Donald D., Process for in-situ passivation of partially-dried coal.
  38. Remington,Benjamin J.; Bearss,David J.; Shahi,Kavian, Spinal fusion using an HMG-CoA reductase inhibitor.
  39. Hayward, Marshall A.; Schmidt, Timo, Stable effervescent bisphosphonate formulations with rapid solubilization characteristics.
  40. Gasper,Shirley R.; West,Robert R.; Martinez,Theresa; Robbins,Kirk G.; McKernan,Patricia A.; Baindur,Nand; Labroo,Virender M.; Mundy,Gregory R., Topical administration of statins for treatment of bone disorders.

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