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CDR grafted humanised chimeric T-cell antibodies 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-035/16
  • A61K-039/00
  • A61K-039/395
  • C07K-016/00
출원번호 US-0244626 (1994-07-15)
우선권정보 GB-0025979 (1991-12-06)
국제출원번호 PCT/GB92/02251 (1992-12-04)
§371/§102 date 19940603 (19940603)
국제공개번호 WO-9311237 (1993-06-10)
발명자 / 주소
  • Waldmann Herman (University of Cambridge
  • Department of Pathology
  • Immunology Div.
  • Tennis Court Road Cambridge
  • CB2 1QP GB3) Walsh Louise (The University of Cambridge
  • Department of Pathology
인용정보 피인용 횟수 : 100  인용 특허 : 0

초록 ▼

A humanised antibody is provided in which the amino acid sequence of the CDRs is derived from the sequence of CDRs of a monoclonal antibody having the specificity of binding to resting and activated T-cells, inhibiting T-cell proliferation and lysing T-cells from mice transgenic for human CD2 and in

대표청구항 ▼

A humanised antibody that specifically binds resting and activated T-cells, inhibits T-Cell proliferation and lyses T-cells from mice transgenic for human CD2, the heavy and light chain variable domains of said antibody are composed of framework and complementary determining regions, wherein light c

이 특허를 인용한 특허 (100)

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