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Method of inhibiting glycolipid synthesis 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/445
  • C07D-211/46
출원번호 US-0439842 (1995-05-12)
발명자 / 주소
  • Platt Frances M. (Oxford MO GBX) Neises Gabrielle R. (Chesterfield MO) Dwek Raymond A. (Oxford GBX) Butters Terry D. (Oxford GBX)
출원인 / 주소
  • Monsanto Company (St. Louis MO 02)
인용정보 피인용 횟수 : 52  인용 특허 : 0

초록

A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.

대표청구항 ▼

The method of inhibiting the biosynthesis of glycolipids in human cells capable of producing glycolipids comprising subjecting said cells in vitro to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon ato

이 특허를 인용한 특허 (52)

  1. Siegel, Craig; Bastos, Cecilia M.; Harris, David J.; Dios, Angeles; Lee, Edward; Silva, Richard; Cuff, Lisa M.; Levine, Mikaela; Celatka, Cassandra A.; Jozafiak, Thomas H.; Vinick, Frederic; Xiang, Yibin; Kane, John; Liao, Junkai, 2-acylaminopropoanol-type glucosylceramide synthase inhibitors.
    상세보기
  2. Siegel, Craig; Bastos, Cecilia M.; Harris, David J.; Dios, Angeles; Lee, Edward; Silva, Richard; Cuff, Lisa M.; Levine, Mikaela; Celatka, Cassandra A.; Jozefiak, Thomas H.; Vinick, Frederic; Xiang, Yibin; Kane, John; Liao, Junkai, 2-acylaminopropoanol-type glucosylceramide synthase inhibitors.
    상세보기
  3. Siegel, Craig; Bastos, Cecilia M.; Harris, David J.; Dios, Angeles; Lee, Edward; Silva, Richard; Cuff, Lisa M.; Levine, Mikaela; Celatka, Cassandra A.; Jozefiak, Thomas H.; Vinick, Frederic; Xiang, Yibin; Kane, John; Liao, Junkai, 2-acylaminopropoanol-type glucosylceramide synthase inhibitors.
    상세보기
  4. Siegel, Craig; Bastos, Cecilia M.; Harris, David J.; Dios, Angeles; Lee, Edward; Silva, Richard; Cuff, Lisa M.; Levine, Mikaela; Celatka, Cassandra A.; Vinick, Frederic; Jozefiak, Thomas H.; Xiang, Yibin; Kane, John; Liao, Junkai, 2-acylaminopropoanol-type glucosylceramide synthase inhibitors.
    상세보기
  5. Siegel, Craig; Bastos, Cecilia M.; Harris, David J.; Dios, Angeles; Lee, Edward; Silva, Richard; Cuff, Lisa M.; Levine, Mikaela; Celatka, Cassandra A.; Vinick, Frederic; Jozefiak, Thomas H.; Xiang, Yibin; Kane, John; Liao, Junkai, 2-acylaminopropoanol-type glucosylceramide synthase inhibitors.
    상세보기
  6. Siegel, Craig; Bastos, Cecilia M.; Harris, David J.; Dios, Angeles; Lee, Edward; Silva, Richard; Cuff, Lisa M.; Levine, Mikaela; Celatka, Cassandra A.; Vinick, Frederic; Jozefiak, Thomas H.; Xiang, Yibin; Kane, John; Liao, Junkai, 2-acylaminopropoanol-type glucosylceramide synthase inhibitors.
    상세보기
  7. Pitkethly, Scott; Masleid, Robert Paul, Advanced repeater utilizing signal distribution delay.
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  8. Pitkethly, Scott, Advanced repeater with duty cycle adjustment.
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  9. Pitkethly, Scott, Advanced repeater with duty cycle adjustment.
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  10. Pitkethly, Scott, Advanced repeater with duty cycle adjustment.
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  11. Hoskins Jo Ann ; Skatrud Paul Luther ; Peery Robert Brown, Biosynthetic gene murg from streptococcus pneumoniae.
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  12. Masleid, Robert Paul; Dholabhai, Vatsal, Circuit with enhanced mode and normal mode.
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  13. Masleid, Robert Paul; Kowalczyk, Andre, Circuits and methods for detecting and assisting wire transitions.
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  14. Masleid, Robert, Circuits, systems and methods relating to a dynamic dual domino ring oscillator.
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  15. Masleid, Robert Paul, Column select multiplexer circuit for a domino random access memory array.
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  16. Jacob, Gary S.; Block, Timothy M.; Dwek, Raymond A., Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy.
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  17. Masleid, Robert Paul, Configurable delay chain with stacked inverter delay elements.
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  18. Masleid, Robert Paul, Configurable delay chain with switching control for tail delay elements.
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  19. Masleid, Robert Paul, Configurable tapered delay chain with multiple sizes of delay elements.
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  20. Masleid, Robert P, Dynamic ring oscillators.
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  21. Mueller, Richard A.; Bryant, Martin L.; Partis, Richard A., Glucamine compounds for treating hepatitis virus infections.
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  22. Mueller, Richard A.; Bryant, Martin L.; Partis, Richard A., Glucamine salts for treating hepatitis virus infections.
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  23. Ibraghimov-Beskrovnaya, Oxana; Natoli, Thomas, Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease.
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  24. Ibraghimov-Beskrovnaya, Oxana; Natoli, Thomas A., Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease.
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  25. Ibraghimov-Beskrovnaya, Oxana; Natoli, Thomas A., Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease.
    상세보기
  26. Larsen, Scott D.; Abe, Akira; Shu, Liming; Wilson, Michael William; Keep, Richard F.; Sun, Duxin; Shayman, James A., Glucosylceramide synthase inhibitors and therapeutic methods using the same.
    상세보기
  27. Larsen, Scott; Abe, Akira; Shu, Liming; Wilson, Michael William; Keep, Richard F.; Shayman, James A., Glucosylceramide synthase inhibitors and therapeutic methods using the same.
    상세보기
  28. Butters, Terry D.; Platt, Frances M.; Dwek, Raymond A., Inhibition of glycolipid biosynthesis.
    상세보기
  29. Terry D. Butters GB; Frances M. Platt GB; Raymond A. Dwek GB, Inhibition of glycolipid biosynthesis.
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  30. Masleid, Robert P, Inverting zipper repeater circuit.
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  31. Masleid, Robert P., Inverting zipper repeater circuit.
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  32. Masleid, Robert Paul, Inverting zipper repeater circuit.
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  33. Masleid, Robert, Leakage efficient anti-glitch filter.
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  34. Cheng, Seng H.; Yew, Nelson S.; Scheule, Ronald K.; Zhao, Hongmei, Method of lowering blood glucose.
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  35. Natoli, Thomas A.; Ibraghimov-Beskrovnaya, Oxana; Leonard, John P.; Yew, Nelson S.; Cheng, Seng H., Method of treating polycystic kidney diseases with ceramide derivatives.
    상세보기
  36. Natoli, Thomas A.; Ibraghimov-Beskrovnaya, Oxana; Leonard, John P.; Yew, Nelson S.; Cheng, Seng H., Method of treating polycystic kidney diseases with ceramide derivatives.
    상세보기
  37. Jacob, Gary S.; Block, Timothy M.; Dwek, Raymond A., Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy.
    상세보기
  38. Cheng, Seng H.; Yew, Nelson S.; Scheule, Ronald K.; Zhao, Hongmei, Methods of treating diabetes mellitus.
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  39. Zhao, Hongmei; Yew, Nelson S.; Cheng, Seng H.; Jiang, Canwen; Arbeeny, Cynthia Marie, Methods of treating fatty liver disease.
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  40. Zhao, Hongmei; Yew, Nelson S.; Cheng, Seng H.; Jiang, Canwen; Arbeeny, Cynthia Marie, Methods of treating fatty liver disease.
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  41. Masleid, Robert Paul, Power efficient multiplexer.
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  42. Masleid, Robert Paul, Power efficient multiplexer.
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  43. Masleid, Robert Paul, Power efficient multiplexer.
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  44. Masleid, Robert Paul, Power efficient multiplexer.
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  45. Masleid, Robert Paul; Dholabhai, Vatsal; Klingner, Christian, Repeater circuit having different operating and reset voltage ranges, and methods thereof.
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  46. Masleid, Robert Paul; Dholabhai, Vatsal, Repeater circuit with high performance repeater mode and normal repeater mode, wherein high performance repeater mode has fast reset capability.
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  47. Stoiber, Steven T.; Siu, Stuart, Ring based impedance control of an output driver.
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  48. Stoiber, Steven T.; Siu, Stuart, Ring based impedance control of an output driver.
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  49. Masleid, Robert P.; Burr, James B., Stacked inverter delay chain.
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  50. Mueller, Richard A.; Bryant, Martin L.; Partis, Richard A.; Jacob, Gary S.; Block, Timothy M.; Dwek, Raymond A., Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections.
    상세보기
  51. Jacob Gary S., Use of alkylated iminosugars to treat multidrug resistance.
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  52. Mueller, Richard A.; Bryant, Martin L.; Partis, Richard A., Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections.
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