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Taxol derivatives 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07D-305/14
  • A61K-031/335
출원번호 US-0317978 (1994-10-04)
발명자 / 주소
  • Gunawardana Geewananda P. (Libertyville IL) Klein Larry L. (Lake Forest IL) McAlpine James B. (Libertyville IL)
출원인 / 주소
  • Abbott Laboratories (Abbott Park IL 02)
인용정보 피인용 횟수 : 41  인용 특허 : 0

초록

Compounds having the formula [Figure] wherein -OR1 comprises the C-13 side-chain of taxol and R3 comprises hydrogen, as well as a method for the preparation thereof.

대표청구항

A compound having the formula [Figure] wherein R1 is a group having the formula [Figure] in which R8 is selected from the group consisting of hydrogen, phenyl, substituted phenyl, alkoxy, substituted alkoxy, amino, substituted amino, phenoxy and substituted phenoxy; R9 is selected from the group con

이 특허를 인용한 특허 (41)

  1. Holton, Robert A.; Somoza, Carmen; Suzuki, Yukio; Shindo, Mitsuru, 14-hydrido-9β-hydroxytetracyclic taxanes.
  2. Holton Robert A. ; Somoza Carmen ; Suzuki Yukio ; Shindo Mitsuru, 9-desoxobaccatin III and analogs thereof.
  3. Robert A. Holton ; Carmen Somoza ; Yukio Suzuki JP; Mitsuru Shindo JP, 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes.
  4. Holton, Robert A.; Somoza, Carmen; Suzuki, Yukio; Shindo, Mitsuru, 9β-hydroxytetracyclic taxanes.
  5. Holton Robert A. ; Nadizadeh Hossain ; Rengan Kasthuri ; Tao Chunlin, Amino substituted taxanes.
  6. Einbond, Linda Saxe, Anti-neoplastic compositions comprising extracts of black cohosh.
  7. Einbond, Linda Saxe; Weinstein, I. Bernard, Anti-neoplastic compositions comprising extracts of black cohosh.
  8. Holton Robert A. ; Chai Ki-byung,KRX, C10 tricyclic taxanes.
  9. Robert A. Holton ; Hossain Nadizadeh ; Kasthuri Rengan ; Chunlin Tao, C13 amido substituted taxane derivatives and pharmaceutical compositions containing them.
  10. Robert A. Holton ; Ki-Byung Chai KR, C7 acyloxy and hydrido taxane derivatives and pharmaceutical compositions containing them.
  11. Holton, Robert A.; Chai, Ki-byung, C7 acyloxy metal alkoxides.
  12. Holton, Robert A., C7 ester substituted taxanes.
  13. Holton,Robert A., C7 ester substituted taxanes.
  14. Holton,Robert A.; Kim,Hyeong Baik, C7 lactyloxy-substituted taxanes.
  15. Holton Robert A. ; Chai Ki-byung,KRX, C7 tricyclic taxanes.
  16. Holton Robert A. ; Somoza Carmen ; Suzuki Yukio ; Shindo Mitsuru, C9 taxane derivatives.
  17. Holton, Robert A.; Nadizadeh, Hossain; Rengan, Kasthuri; Tao, Chunlin, Carbamoyl substituted ß-lactams.
  18. Friedman, Steven M.; Scherle, Peggy A.; Liu, Xiangdong; Vaddi, Krishna; Fridman, Jordan S., Compositions, methods and kits relating to HER-2 cleavage.
  19. Greenwald Richard B. ; Pendri Annapurna ; Zhao Hong, High molecular weight polymer-based prodrugs.
  20. Greenwald Richard B. ; Pendri Annapurna ; Zhao Hong, High molecular weight polymer-based prodrugs.
  21. Sisti Nicholas J. (Jeffersonville PA) Swindell Charles S. (Merion PA), Method for docetaxel synthesis.
  22. Zebala, John A.; Maeda, Dean Y.; Schuler, Aaron D., Method for treating cancer using chemokine antagonists.
  23. Naidu, Ragina, One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel.
  24. Liu Jian,CAX, Process for converting 9-dihydro-13-acetylbaccatin III into taxol and derivatives thereof.
  25. Trung Bui-Khac CA; Nicolas Dupuis CA, Process for extraction and purification of paclitaxel from natural sources.
  26. Bui-Khac, Trung; Potier, Michel, Process for isolation and purification of paclitaxel from natural sources.
  27. Gertrude C. Kasitu CA; Japheth Noah CA; Qasim Khan CA, Process for mass production of GMP paclitaxel and related taxanes.
  28. Amedio, Jr., John C.; Wallner, Barbara; Komarnitsky, Philip B., Salts of isophosphoramide mustard and analogs thereof.
  29. Morgan, Lee R., Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents.
  30. Naidu, Ragina; Foo, Samuel Siang Kiang, Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes.
  31. Liu, Jian, Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III.
  32. Waligora, Frank W.; Amedio, Jr., John C., Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof.
  33. Waligora, Frank W.; Amedio, Jr., John C., Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof.
  34. Waligora, Frank Walter; Amedio, John C., Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof.
  35. Greenwald Richard B. ; Pendri Annapurna, Taxane-based prodrugs.
  36. Holton, Robert A.; Chai, Ki-byung; Idmoumaz, Hamid; Nadizadeh, Hossain; Rengan, Kasthuri; Suzuki, Yukio; Tao, Chunlin, Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them.
  37. Zebala, John A.; Maeda, Dean Y.; Schuler, Aaron D., Thiopyrimidinecarboxamide for use in treating pulmonary disease.
  38. Maeda, Dean Y.; Zebala, John A.; Schuler, Aaron D., Thiopyrimidinecarboxamides as CXCR1/2 modulators.
  39. Holton Robert A. ; Chai Ki-byung,KRX ; Idmoumaz Hamid,FRX ; Nadizadeh Hossain ; Rengan Kasthuri ; Suzuki Yukio ; Tao Chunlin, Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them.
  40. Zebala, John A.; Maeda, Dean Y.; Schuler, Aaron D., Use of thiopyrimidinecarboxamide for treating cancer.
  41. Zebala, John A.; Maeda, Dean Y.; Schuler, Aaron D., Use of thiopyrimidinecarboxamide for treating cancer.
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