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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0054363 (1993-04-26) |
발명자 / 주소 |
|
인용정보 | 피인용 횟수 : 473 인용 특허 : 0 |
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
A compound having the formula: [Figure] [Figure] wherein: each L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moleties, naturally occurring nucleobases, and non-naturally occurring nucleobases; each R3 is independently selected from the group consisting of hy
A compound having the formula: [Figure] [Figure] wherein: each L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moleties, naturally occurring nucleobases, and non-naturally occurring nucleobases; each R3 is independently selected from the group consisting of hydrogen, (C1-C4)alkyl, hydroxy- or alkoxy- or alkylthio-substituted (C1-C4)alkyl, hydroxy, alkoxy, alkylthio and amino; each R7′is independently selected from the group consisting of hydrogen and the side chains of naturally occurring alpha amino acids; n is an integer from 1 to 60, each k, l, and m is, independently, zero or an integer from 1 to 5; each p is zero or 1; Rh is OH, NH2 or -NHLysNH2; and Ri is H or COCH3.
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