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Peptide nucleic acids 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-007/00
  • C07H-005/04
  • C07H-021/04
  • C07D-239/00
출원번호 US-0054363 (1993-04-26)
발명자 / 주소
  • Nielsen Peter E. (Hjortevanget 509 DK 2980 Kokkedal DKX) Buchardt Ole (Sondergardsvej 73 DK 3500 Vaerlose DKX) Egholm Michael (Johnstrup Alle 3 DK 1923 Frederiksberg DKX) Berg Rolf H. (Strandvaenget
인용정보 피인용 횟수 : 473  인용 특허 : 0

초록

A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

대표청구항

A compound having the formula: [Figure] [Figure] wherein: each L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moleties, naturally occurring nucleobases, and non-naturally occurring nucleobases; each R3 is independently selected from the group consisting of hy

이 특허를 인용한 특허 (473)

  1. Prakash, Thazha P.; Baker, Brenda F.; Eldrup, Anne B.; Manoharan, Muthiah; Bhat, Balkrishen; Griffey, Richard; Swayze, Eric E.; Crooke, Stanley T., 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations.
  2. Baryza, Jeremy Lee; Blommers, Marcel; Fernandez, Cesar; Geno, Erin; Gossert, Alvar; Greenidge, Paulette; Huesken, Dieter; Hunziker, Juerg; Natt, Francois Jean-Charles; Patnaik, Anup; Patterson, Andrew; Rondeau, Jean-Michel Rene; Weiler, Jan; Zhu, Meicheng, 3′end caps for RNAi agents for use in RNA interference.
  3. Manoharan, Muthiah; Rajeev, Kallanthottathil G.; Zlatev, Ivan; Swayze, Eric E.; Prakash, Thazha P.; Lima, Walter F., 5′-end derivatives.
  4. Kelly, Karen M.; Lewin, David A.; Stewart, Timothy A., Acidic mammalian proteins and polynucleotides encoding the same.
  5. Christensen, Leif; Hansen, Henrik Frydenlund; Nielsen, Peter E., Admixture comprising a target molecule and a nucleic acid mimic comprising sterically bulky substituents.
  6. Hope, Michael J.; Semple, Sean C.; Chen, Jianxin; Madden, Thomas D.; Cullis, Pieter R.; Ciufolini, Marco A.; Mui, Barbara Low Shoud, Amino lipids and methods for the delivery of nucleic acids.
  7. Erikson, Glen H., Amperometric affinity assay and electrically stimulated complexes of nucleic acids.
  8. Dean,Frank B.; Lasken,Roger S.; Fang,Linhua; Faruqi,A. Fawad; Alsmadi,Osama A.; Driscoll,Mark D.; Hosono,Seiyu; Wisniewski,Michele; Song,Wanmin, Amplification of denatured and stabilized nucleic acids.
  9. Wu, Yan; van Lookeren-Campagne, Menno; Kirchhofer, Daniel; Lipari, Michael Terry; Katschke, Jr., Kenneth J.; Moran, Paul M.; Stawicki, Scott; Liang, Wei-Ching, Anti-HtrA1 antibodies and methods of use.
  10. Cairns, Belinda; Chen, Ruihuan; Frantz, Gretchen; Hillan, Kenneth J.; Koeppen, Hartmut; Phillips, Heidi S.; Polakis, Paul; Spencer, Susan D.; Smith, Victoria; Williams, P. Mickey; Wu, Thomas D.; Zhang, Zemin, Anti-TAT188 antibodies.
  11. Nielsen Peter E.,DKX ; Good Liam,DKX, Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor.
  12. Weller, Dwight D.; Geller, Bruce L.; Iversen, Patrick L.; Tilley, Lucas D.; Hassinger, Jed N., Antibacterial antisense oligonucleotide and method.
  13. Gurney, Austin L.; Sato, Aaron Ken; Axelrod, Fumiko Takada; Hoey, Timothy Charles; Satyal, Sanjeev H.; Mitra, Satyajit Sujit Kumar, Antibodies against human FZD5 and FZD8.
  14. Cairns, Belinda; Chen, Ruihuan; Frantz, Gretchen; Hillan, Kenneth J.; Koeppen, Hartmut; Phillips, Heidi S.; Polakis, Paul; Spencer, Susan D.; Smith, Victoria; Williams, P. Mickey; Wu, Thomas D.; Zhang, Zemin; Sakanaka, Chie; Chuntharapai, Anan; Reed, Chae Janeka, Antibody compositions for the diagnosis and treatment of tumor.
  15. Altman, Sidney; Bothwell, Alfred; Mamoum, Choukri, Antimicrobial compositions and methods of use thereof.
  16. Karelson, Mati; Saarma, Mart; Pilv, Mehis, Antisense agents combining strongly bound base-modified oligonucleotide and artificial nuclease.
  17. Iversen, Patrick L., Antisense antiviral compound and method for treating influenza viral infection.
  18. Iversen, Patrick L., Antisense antiviral compound and method for treating influenza viral infection.
  19. Mourich, Dan V.; Marshall, Nikki B.; Iversen, Patrick L., Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis.
  20. Armstrong, Dustin D., Antisense conjugates for decreasing expression of DMPK.
  21. Armstrong, Dustin D., Antisense conjugates for decreasing expression of DMPK.
  22. Bennett, C. Frank; Cowsert, Lex M.; Siwkowski, Andrew M., Antisense modulation of CD40 expression.
  23. Malone, Brett; Bryson, Joshua, Antisense molecules for treatment of Staphylococcus aureus infection.
  24. Malone, Brett; Bryson, Joshua, Antisense molecules for treatment of staphylococcus aureus infection.
  25. Dean Nicholas M. ; McKay Robert ; Miraglia Loren ; Baker Brenda, Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos.
  26. McKay Robert ; Dean Nicholas ; Monia Brett P. ; Nero Pamela S. ; Gaarde William A., Antisense oligonucleotide compositions and methods for the modulation of JNK proteins.
  27. McKay Robert ; Dean Nicholas ; Monia Brett P. ; Nero Pamela Scott ; Gaarde William A., Antisense oligonucleotide compositions and methods for the modulation of JNK proteins.
  28. McKay, Robert; Dean, Nicholas M.; Monia, Brett P.; Nero, Pamela; Gaarde, William A., Antisense oligonucleotide compositions and methods for the modulation of JNK proteins.
  29. Dean Nicholas M. ; McKay Robert ; Miraglia Loren ; Baker Brenda, Antisense oligonucleotide compositions and methods for the modulation of activating protein 1.
  30. Bennett C. Frank ; Lipton Allan ; Witters Lois M., Antisense oligonucleotide modulation of human HER-2 expression.
  31. McKay Robert ; Dean Nicholas M., Antisense oligonucleotides against JNK.
  32. Burzio Eriz, Luis O.; Burzio Menendez, Veronica A.; Villegas Olavarria, Jaime E., Antisense oligonucleotides for treatment of cancer stem cells.
  33. C. Frank Bennett ; Nicholas M. Dean ; Phillip Dan Cook ; Glenn Hoke, Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate .beta.I, .beta.II, .gamma., .delta., .EPSILON., .zeta. and .eta. isoforms of human protein kin.
  34. Riley, Timothy A.; Brown, Bob D.; Arnold, Lyle J., Antisense oligonucleotides with increased RNase sensitivity.
  35. McNally, Elizabeth, Antisense polynucleotides to induce exon skipping and methods of treating dystrophies.
  36. McNally, Elizabeth, Antisense polynucleotides to induce exon skipping and methods of treating dystrophies.
  37. Dimitrov, Valentin; Weiner, Nathan, Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation.
  38. Erikson,Glen H., Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions.
  39. Erikson, Glen H.; Daksis, Jasmine I., Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes.
  40. Myers,Andrew G.; LaPorte,Jacob R.; Xing,Chengguo, Assay for identifying biological targets of polynucleotide-binding compounds.
  41. Oliver, John S., Assay methods using nicking endonucleases.
  42. Oliver, John S., Assay methods using nicking endonucleases.
  43. Bornhop, Darryl J.; Mousa, Mina; Kussrow, Amanda, Backscattering interferometric methods.
  44. Dixon, Darren J.; Farley, Alistair J.; Núñez, Marta G., Bifunctional organic catalysts.
  45. Pieken, Wolfgang; Hill, Ken; Eaton, Bruce; McGee, Danny; Vagle, Kurt; Gold, Larry; Stephens, Andrew, Bioconjugation of macromolecules.
  46. Oliver, John; Bready, Barrett; Goldstein, Peter; Preparata, Franco, Biopolymer Sequencing By Hybridization of probes to form ternary complexes and variable range alignment.
  47. Oliver, John; Bready, Barrett; Goldstein, Peter; Preparata, Franco, Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment.
  48. Gunn, III, Lawrence Cary; Iqbal, Muzammil; Spaugh, Brad; Tybor, Frank, Biosensors based on optical probing and sensing.
  49. Cojocaru, Gady S.; Rotman, Galit; Levine, Zurit; Dassa, Liat; Levi, Ofer; Briante, Raffaella; Singh, Shweta; Watson, Susan R.; Pergam, Tania, C10RF32 antibodies, and uses thereof for treatment of cancer.
  50. Naor, David; Nedvetzki, Shlomo; Golan, Itshak; Kessel, Irina; Melnik, Lora, CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases.
  51. Naor, David; Nedvetzki, Shlomo; Golan, Itshak; Kessel, Irina; Melnik, Lora, CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases.
  52. Slaton, Joel W.; Ahmed, Khalil; Unger, Gretchen M.; Davis, Alan; Sloper, Dan, Casein kinase 2 antisense therapy.
  53. Glen H. Erikson TC; Jasmine I. Daksis CA; Pierre Picard CA, Cation mediated triplex hybridization assay.
  54. Siebenkotten, Gregor; Christine, Rainer, Cellular transport system for the transfer of a nucleic acid through the nuclear envelope and methods thereof.
  55. Crooke, Stanley T., Chimeric oligomeric compounds and their use in gene modulation.
  56. Teng Kelly, Chiral peptide nucleic acids and methods for preparing same.
  57. Krotz, Achim; Capaldi, Daniel C.; Gaus, Hans-Joachim Josef; Turney, Brett, Chloral-free DCA in oligonucleotide synthesis.
  58. Krotz,Achim; Capaldi,Daniel; Gaus,Hans; Turney,Brett, Chloral-free DCA in oligonucleotide synthesis.
  59. Fisher,Paul B.; Su,Zao Zhong, Combinatorial methods for inducing cancer cell death.
  60. Evriklia, Lianidou; Stathopoulou, Aliki; Mavroudis, Dimitrios; Georgoulias, Vasileios, Composition and method for determination of CK19 expression.
  61. Yuan Lung-Chi J., Composition and method for storing nucleotide analogs.
  62. Bennett, Clarence Frank; Ecker, David J.; Cook, Phillip Dan, Composition and methods for the pulmonary delivery of nucleic acids.
  63. Kochel Bonawentura,PLX, Composition containing peptides and nucleic acids and methods of making same.
  64. Matthiesen, Steen Hauge, Compositions and methods for RNA hybridization applications.
  65. Johansen, Jack T., Compositions and methods for detecting target analytes.
  66. Cunningham, Melissa M.; Stull, Paul D.; Weisburg, William G., Compositions and methods for detecting the presence of Cryptosporidium parvum in a test sample.
  67. Cunningham, Melissa M.; Stull, Paul D.; Weisburg, William G., Compositions and methods for detecting the presence of cryptosporidium organisms in a test sample.
  68. Matthiesen, Steen Hauge; Petersen, Kenneth H.; Poulsen, Tim Svenstrup, Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers.
  69. Gurney, Austin; Lewicki, John; Satyal, Sanjeev; Hoey, Timothy, Compositions and methods for diagnosing and treating cancer.
  70. Cook, Phillip Dan; Manoharan, Muthiah; Bennett, Clarence Frank, Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals.
  71. Sah, Dinah Wen-Yee; Hadwiger, Philipp; Roehl, Ingo; Bramlage, Birgit; Tan, Pamela; Vornlocher, Hans-Peter; Bumcrot, David, Compositions and methods for inhibiting expression of Huntingtin gene.
  72. Sah,Dinah Wen Yee; Hadwiger,Philipp; Roehl,Ingo; Bramlage,Birgit; Tan,Pamela; Vornlocher,Hans Peter; Bumcrot,David, Compositions and methods for inhibiting expression of Huntingtin gene.
  73. Boylan, John Frederick; Bramlage, Birgit; Hossbach, Markus; Reidhaar-Olson, John, Compositions and methods for inhibiting expression of RRM2 genes.
  74. Boylan, John Frederick; Bramlage, Birgit; Hossbach, Markus; Reidhaar-Olson, John, Compositions and methods for inhibiting expression of RRM2 genes.
  75. Sah, Dinah Wen-Yee; Hadwiger, Philipp; Roehl, Ingo; Bramlage, Birgit; Tan, Pamela; Vornlocher, Hans-Peter; Bumcrot, David, Compositions and methods for inhibiting expression of huntingtin gene.
  76. Wooddell, Christine I; Lewis, David L; Wakefield, Darren H; Almeida, Lauren; Kanner, Steven B, Compositions and methods for inhibiting gene expression of alpha-1 AntiTrypsin.
  77. Chin, Daniel; Deckert, Jochen; Hossbach, Markus; John, Matthias, Compositions and methods for inhibiting gene expression of hepatitis B virus.
  78. Li, Dean; Jones, Christopher; London, Nyall, Compositions and methods for inhibiting vascular permeability.
  79. Teng, Ching-Leou; Cook, Phillip Dan; Tillman, Lloyd; Hardee, Gregory E.; Ecker, David J.; Manoharan, Muthiah, Compositions and methods for non-parenteral delivery of oligonucleotides.
  80. Teng, Ching-Leou; Cook, Phillip Dan; Tillman, Lloyd; Hardee, Gregory E.; Ecker, David J.; Manoharan, Muthiah, Compositions and methods for non-parenteral delivery of oligonucleotides.
  81. Teng, Ching-Leou; Cook, Phillip Dan; Tillman, Lloyd; Hardee, Gregory E.; Ecker, David J.; Manoharan, Muthiah, Compositions and methods for non-parenteral delivery of oligonucleotides.
  82. Matthiesen, Steen Hauge, Compositions and methods for performing a stringent wash step in hybridization applications.
  83. Matthiesen, Steen Hauge, Compositions and methods for performing hybridizations with separate denaturation of the sample and probe.
  84. Matthiesen, Steen Hauge, Compositions and methods for performing hybridizations with separate denaturation of the sample and probe.
  85. Rozners, Eriks; Zengeya, Thomas, Compositions and methods for recognition of RNA using triple helical peptide nucleic acids.
  86. Teng, Ching-Leou; Hardee, Greg, Compositions and methods for the delivery of oligonucleotides via the alimentary canal.
  87. Webster, Philippa J.; Dennis, Lucas M.; Boykin, Richard K., Compositions and methods for the detection of small RNAs.
  88. Yu, Xing-Xian; Bhanot, Sanjay, Compositions and methods for the modulation of JNK proteins.
  89. Mehta, Rahul C.; Hardee, Gregory E.; Cook, Phillip Dan; Ecker, David J.; Tsai, Yali Jennifer; Templin, Michael V., Compositions and methods for topical delivery of oligonucleotides.
  90. Clarke, Michael F.; Hoey, Tim; Wang, Xinhao; Dylla, Scott; Gurney, Austin; Dalerba, Piero; Prince, Mark; Chen, Grace, Compositions and methods for treating and diagnosing cancer.
  91. Simeone, Diane M.; Clarke, Michael F., Compositions and methods for treating and diagnosing pancreatic cancer.
  92. Simeone, Diane M.; Clarke, Michael F., Compositions and methods for treating and diagnosing pancreatic cancer.
  93. Li, Dean; Jones, Christopher; London, Nyall, Compositions and methods for treating ocular pathologic angiogenesis and vascular permeability.
  94. Zick,Yehiel; Levy,Yifat; Arbel Goren,Rinat; Ronen,Denise; Hadari,Yaron R., Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth.
  95. Zick,Yehiel; Levy,Yifat; Arbel Goren,Rinat; Ronen,Denise; Hadari,Yaron R., Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth.
  96. Dobie, Kenneth W.; Dean, Nicholas M.; Bennett, C. Frank, Compositions and their uses directed to HBXIP.
  97. Coull, James M.; Gildea, Brian D.; Hyldig-Nielsen, Jens J., Compositions comprising a linked acceptor moiety.
  98. Allerson, Charles; Bhat, Balkrishen; Eldrup, Anne B.; Manoharan, Muthiah; Griffey, Richard H.; Baker, Brenda F.; Swayze, Eric E., Compositions comprising alternating 2′-modified nucleosides for use in gene modulation.
  99. Komoriya, Akira; Packard, Beverly S., Compositions for the detection of enzyme activity in biological samples and methods of use thereof.
  100. Packard, Beverly S.; Komoriya, Akira, Compositions for the detection of enzyme activity in biological samples and methods of use thereof.
  101. Packard,Beverly S.; Komoriya,Akira, Compositions for the detection of enzyme activity in biological samples and methods of use thereof.
  102. Bloch William ; Werner William E. ; Egholm Michael ; Myers Rene L., Compositions of solvents and high concentrations of nucleic acid analogs.
  103. Kaplan, Shannon K.; Livezey, Kristin; Bungo, Jennifer J.; Hogan, James J., Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa.
  104. Reshatoff, Michael R.; Ong, Edgar O.; Hogan, James J., Compositions, kits and related methods for the detection and/or monitoring of Salmonella.
  105. Reshatoff, Michael R.; Ong, Edgar O.; Hogan, James J., Compositions, kits and related methods for the detection and/or monitoring of Salmonella.
  106. Cunningham,Melissa M.; Stull,Paul D.; Weisburg,William G., Compositions, methods and kits for determining the presence oforganisms in a test sample.
  107. Neilsen, Peter E.; Knudsen, Helle, Conjugated peptide nucleic acids having enhanced cellular uptake.
  108. Peter E. Nielsen DK; Helle Knudsen DK, Conjugated peptide nucleic acids having enhanced cellular uptake.
  109. Bennett, C. Frank; McKay, Robert; Monia, Brett P.; Baker, Brenda F.; Sioufi, Namir, Conjugates for use in hepatocyte free uptake assays.
  110. Satterfield, Brent C., Cooperative primers, probes, and applications thereof.
  111. Peled, Tony; Steinhardt, Yair, Culturing of mesenchymal stem cells with FGF4 and nicotinamide.
  112. Arlinghaus Heinrich F. ; Jacobson K. Bruce, DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA.
  113. Markovitz, David M.; Mor-Vaknin, Nirit; Khodadoust, Michael; Adams, Barbara S., Dek protein compositions and methods of using the same.
  114. Mirkin, Chad A.; Paller, Amy S.; Giljohann, David A., Delivery of oligonucleotide functionalized nanoparticles.
  115. Cohenford, Menashi A.; Lentrichia, Brian, Detection and typing of human papillomavirus using PNA probes.
  116. Cohenford, Menashi A.; Lentrichia, Brian, Detection and typing of human papillomavirus using PNA probes.
  117. Kumar, Gyanendra; Abarzua, Patricio; Egholm, Michael, Detection method using dissociated rolling circle amplification.
  118. Huang, Shihai X.; Granados, Edward N., Detection of bisulfite converted nucleotide sequences.
  119. Gildea,Brian D.; Coull,James M.; Hyldig Nielsen,Jens J.; Fiandaca,Mark J., Detection of nucleic acid using linear beacons.
  120. Ho, Shiaolan Y.; Shah, Ankur H.; Chen, Xiaodi, Detection of single nucleotide polymorphisms in human KRAS.
  121. Clarke, Michael F.; Dylla, Scott J.; Satyal, Sanjeev, Determining the capability of a test compound to affect solid tumor stem cells.
  122. Clarke, Michael F.; Dylla, Scott J.; Satyal, Sanjeev, Determining the capability of a test compound to affect solid tumor stem cells.
  123. Carvalho,Maria da Gloria; Sampson,Jacquelyn S.; Ades,Edwin W.; Carlone,George; McCaustland,Karen, Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease.
  124. Oliver, John S.; Ianakiev, Petre, Devices and methods for analyzing biomolecules and probes bound thereto.
  125. Oliver, John S., Devices and methods for determining the length of biopolymers and distances between probes bound thereto.
  126. Oliver, John S., Devices and methods for determining the length of biopolymers and distances between probes bound thereto.
  127. Oliver, John S., Devices and methods for determining the length of biopolymers and distances between probes bound thereto.
  128. Monia, Brett P.; Freier, Susan M.; Siwkowski, Andrew M.; Guo, Shuling, Diagnosis and treatment of disease.
  129. Baker, Brenda F.; Kraynack, Bryan A., Double stranded constructs comprising one or more short strands hybridized to a longer strand.
  130. Rose, Scott D.; Walder, Joseph A.; Beltz, Kristin; Allen, Shawn, Efficient and rapid method for assembling and cloning double-stranded DNA fragments.
  131. Hanes, Justin; Suk, Jung Soo; Mastorakos, Panagiotis; Woodworth, Graeme; Zhang, Clark, Engineering synthethic brain penetrating gene vectors.
  132. Hamad-Schifferli, Kimberly S.; Park, Sunho, Enhancement of in vitro translation by nanoparticle conjugates.
  133. Hamad-Schifferli, Kimberly S.; Park, Sunho, Enhancement of in vitro translation by nanoparticle conjugates.
  134. Peled, Tony; Frei, Gabi M., Enhancement of natural killer (NK) cell proliferation and activity.
  135. Liu, David R.; Gartner, Zev J.; Calderone, Christopher T., Evolving new molecular function.
  136. Liu, David R.; Gartner, Zev J.; Doyon, Jeffrey B.; Calderone, Christopher T.; Kanan, Matthew W.; Li, Xiaoyu; Snyder, Thomas M.; Rosenbaum, Daniel M., Evolving new molecular function.
  137. Liu, David R.; Gartner, Zev J.; Kanan, Matthew W., Evolving new molecular function.
  138. Liu, David R.; Gartner, Zev J.; Kanan, Matthew W., Evolving new molecular function.
  139. Liu,David R.; Gartner,Zev J.; Calderone,Christopher T., Evolving new molecular function.
  140. Liu,David R.; Gartner,Zev J.; Kanan,Matthew W., Evolving new molecular function.
  141. Liu,David R.; Gartner,Zev J.; Kanan,Matthew W., Evolving new molecular function.
  142. Liu,David R.; Gartner,Zev; Kanan,Matthew W., Evolving new molecular function.
  143. O'Neill,Roger; Fisher,Peter V., Fluorescent dyes, energy transfer couples and methods.
  144. Jasmine I. Daksis CA; Pierre Picard CA; Glen H. Erikson CA, Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators.
  145. Daksis, Jasmine I.; Erikson, Glen H., Fluorescent intensity method for assaying binding between proteins or peptides.
  146. Baryza, Jeremy Lee; Blommers, Marcel; Chutkow, William; Fernandez, Cesar; Geno, Erin; Gossert, Alvar; Greenidge, Paulette; Huesken, Dieter; Hunziker, Juerg; Natt, Francois Jean-Charles; Patnaik, Anup; Patterson, Andrew; Rondeau, Jean-Michel Rene; Weiler, Jan; Zhu, Meicheng, Formats for organic compounds for use in RNA interference.
  147. Saltzman, W. Mark; Zhang, Junwei; Zhou, Jiangbing; Jiang, Zhaozhong, Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof.
  148. Liu, David R.; Sakurai, Kaori, Free reactant use in nucleic acid-templated synthesis.
  149. Gurney, Austin L., Frizzled-binding agents and their use in screening for WNT inhibitors.
  150. Gurney, Austin L., Frizzled-binding agents and uses thereof.
  151. Vorobiev, Alexei; Lukhtanov, Eugeny A.; Scarr, Noah, Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use.
  152. Vorobiev, Alexei; Lukhtanov, Eugeny A.; Scarr, Noah, Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use.
  153. Hanson, Gunnar J.; Weller, Dwight D.; Cai, Bao Zhong; Zhou, Ming, Functionally-modified oligonucleotides and subunits thereof.
  154. Hanson, Gunnar J.; Weller, Dwight D.; Cai, Bao Zhong; Zhou, Ming, Functionally-modified oligonucleotides and subunits thereof.
  155. Golan, Itshak; Caspi, Dan; Melnik, Lora, Galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases.
  156. Swayze, Eric E.; Migawa, Michael T.; Wyrzykiewicz, Tadeusz Krzysztof, Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini.
  157. Didion, Bradley; Erwin, Whitney; Bleher, Reiner, Gender-specific separation of sperm cells and embryos.
  158. Manoharan, Muthiah; Cook, Phillip Dan; Prakash, Thazha P.; Mohan, Venkatraman, Guanidinium functionalized intermediates.
  159. Manoharan, Muthiah; Cook, Phillip Dan; Prakash, Thazha P.; Mohan, Venkatraman, Guanidinium functionalized nucleotides and precursors thereof.
  160. Manoharan, Muthiah; Cook, Phillip Dan; Prakash, Thazha P.; Mohan, Venkatraman, Guanidinium functionalized oligonucleotides and method/synthesis.
  161. Erikson, Glen H.; Daksis, Jasmine I.; Picard, Pierre, Heteropolymeric triplexes containing watson-crick triplets.
  162. Ecker, David J.; Buchardt, Ole; Egholm, Michael; Nielsen, Peter E.; Berg, Rolf H.; Mollegaard, Niels E., Higher order structure and binding of peptide nucleic acids.
  163. Selitrennikoff, Claude; Pott, Greg, Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use.
  164. Packard, Beverly; Komoriya, Akira, Homo-doubly labeled compositions for the detection of enzyme activity in biological samples.
  165. Packard, Beverly; Komoriya, Akira, Homo-doubly labeled compositions for the detection of enzyme activity in biological samples.
  166. Erikson,Glen H.; Daksis,Jasmine I.; Picard,Pierre, Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions.
  167. Gurney, Austin L.; Lewicki, John; Satyal, Sanjeev; Hoey, Timothy, Human frizzled (FZD) receptor polypeptides and methods of use thereof for treating cancer and inhibiting growth of tumor cells.
  168. Efimov,Vladimir; Fernandez,Joseph; Archdeacon,Dorothy; Archdeacon,John; Chakhmakhcheva,Oksana; Buryakova,Alla; Choob,Mikhail; Hondorp,Kyle, Hydroxyproline/phosphono oligonucleotide analogues, methods of synthesis and methods of use.
  169. David J. Ecker, In situ binary synthesis of biologically effective molecules.
  170. Gildea, Brian D.; Coull, James M.; Hyldig-Nielsen, Jens J., In-situ methods for analyzing target sequences using linear beacons.
  171. Bergan, Raymond C.; Scheidt, Karl A., Inhibition and treatment of prostate cancer metastasis.
  172. Bergan, Raymond C.; Scheidt, Karl A., Inhibition and treatment of prostate cancer metastasis.
  173. Leung, Wai Yee; Cheung, Ching Ying; Yue, Stephen, Intermediates and the synthesis of modified carbocyanine dyes and their conjugates.
  174. Gu, Yizhong; Shannon, Mark E., Isoforms of human pregnancy-associated protein-E.
  175. Clarke, Michael F.; Morrison, Sean J.; Wicha, Max S.; Al-Hajj, Muhammad, Isolation and use of solid tumor stem cells.
  176. Clarke, Michael F.; Morrison, Sean J.; Wicha, Max S.; Al-Hajj, Muhammad, Isolation and use of solid tumor stem cells.
  177. Clarke, Michael F.; Morrison, Sean J.; Wicha, Max S.; Al-Hajj, Muhammad, Isolation and use of solid tumor stem cells.
  178. Manoharan, Muthiah, Ligand-conjugated oligomeric compounds.
  179. Mirkin, Chad A.; Nguyen, Sonbinh T.; Banga, Resham Singh; Chernyak, Natalia; Gryaznov, Sergei; Radovic-Moreno, Aleksandar; Mader, Christopher, Liposomal particles, methods of making same and uses thereof.
  180. Larson, Alyssa M.; Love, Kevin; Weight, Alisha K.; Crane, Alan; Langer, Robert S.; Klibanov, Alexander M., Liquid pharmaceutical formulations for injection comprising procaine and uses thereof.
  181. Larson, Alyssa M.; Weight, Alisha K.; Love, Kevin; Crane, Alan; Langer, Robert S.; Klibanov, Alexander M., Liquid pharmaceutical formulations for injection comprising thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole and uses thereof.
  182. Larson, Alyssa M.; Love, Kevin; Weight, Alisha K.; Crane, Alan; Langer, Robert S.; Klibanov, Alexander M., Liquid pharmaceutical formulations for injection comprising yellow 5 or orange G and uses thereof.
  183. Larson, Alyssa M.; Love, Kevin; Weight, Alisha K.; Crane, Alan; Langer, Robert S.; Klibanov, Alexander M., Liquid protein formulations for injection comprising 1-butyl-3-methylimidazolium methanesulfonate and uses thereof.
  184. Gurney, Austin L.; Xie, Ming-Hong; Bond, Christopher John, MET-binding agents and uses thereof.
  185. Joo, Sunghae A.; Dockter, Janel M., Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals.
  186. Korfhage, Christian; Löffert, Dirk, Method for activating a nucleic acid for a polymerase reaction.
  187. Bauer, Stefan, Method for detecting a periodically pulsing operating parameter.
  188. El Shami, A. Said; Menon, Surendra Nath; French, Cynthia K., Method for detecting endometriosis in a patient sample.
  189. Coull, Jeffrey A. M.; De Koninck, Yves, Method for identifying compounds for treatment of pain.
  190. De Koninck, Yves; De Koninck, Paul; Coull, Jeffrey A. M., Method for identifying compounds for treatment of pain.
  191. De Koninck, Yves; De Koninck, Paul; Coull, Jeffrey A. M., Method for identifying compounds for treatment of pain.
  192. Pieken,Wolfgang; Wolter,Andreas; Sebesta,David P.; Leuck,Michael; Latham Timmons,Hallie A.; Pilon,John; Husar,Gregory M., Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method.
  193. Bornarth,Carole; Wisniewski,Michele; Hosono,Seiyu; Raghunathan,Arumugham; Lasken,Roger S., Method for nucleic acid amplification that results in low amplification bias.
  194. Cunningham, Melissa M.; Stull, Paul D.; Weisburg, William G., Method for obtaining purified RNA from viable oocysts.
  195. Maier,Martin A.; Guzaev,Andrei P.; Manoharan,Muthiah, Method for sequential support-bound synthesis of conjugated oligomeric compounds.
  196. Pieken Wolfgang ; Gold Larry, Method for solution phase synthesis of oligonucleotides and peptides.
  197. Pieken Wolfgang ; Gold Larry, Method for solution phase synthesis of oligonucleotides and peptides.
  198. Beier, Markus; Matysiak, Stefan; Hoheisel, Jorg, Method for the light-controlled synthesis of biochips.
  199. Cohen, Robert; Carr, Suzette; Hagerty, David; Peach, Robert James; Becker, Jean-Claude, Method for treating a rheumatic disease using a soluble TLA4 molecule.
  200. Cohen, Robert; Carr, Suzette; Hagerty, David; Peach, Robert James; Becker, Jean-Claude, Method for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID.
  201. Clarke, Michael F.; Wicha, Max S.; Al-Hajj, Muhammad, Method for treating cancer using an antibody that inhibits notch4 signaling.
  202. Gleave, Martin E.; Ischia, Joseph, Method for treatment of castration-resistant prostate cancer.
  203. Dean, Frank B.; Lasken, Roger S., Method of amplifying whole genomes without subjecting the genome to denaturing conditions.
  204. James M. Coull ; Brian D. Gildea ; Jens J. Hyldig-Nielsen, Method, kits and compositions pertaining to detection complexes.
  205. Bailey, Ryan C.; Luchansky, Matthew S.; Qavi, Abraham J.; Kindt, Jared T., Methods and compositions for enhancing immunoassays.
  206. Makarov, Vladimir, Methods and compositions for isolating polynucleotides.
  207. Iversen, Patrick L., Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites.
  208. Liu, Zhitong; Liu, Guoying; Liu, Jeffrey Juehui; Chen, Tao, Methods and compositions for reducing redundant molecular barcodes created in primer extension reactions.
  209. Makarov, Vladimir; Kurihara, Laurie, Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase.
  210. Essner, Jeffrey J.; Liao, Hsin-Kai; Fahrenkrug, Scott C., Methods and compositions for targeted gene modification.
  211. Arar, Khalil, Methods and compositions for the tandem synthesis of two or more oligonucleotides on the same solid support.
  212. Breaker, Ronald R.; Blount, Kenneth F.; Puskarz, Izabela J.; Wickiser, John K., Methods and compositions related to the modulation of riboswitches.
  213. Bennett Clarence Frank ; Manoharan Muthiah ; Hebert Normand ; Bhat Balkrishen, Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations.
  214. Chiou, Chiuan-Chian; Luo, Ji-Dung, Methods and kits for the detection of nucleotide mutations using peptide nucleic acid as both PCR clamp and sensor probe.
  215. Dupont, Jakob; Stagg, Robert J., Methods and monitoring of treatment with a WNT pathway inhibitor.
  216. Dupont, Jakob; Stagg, Robert J., Methods and monitoring of treatment with a Wnt pathway inhibitor.
  217. Villota Arcos, Claudio E.; Villegas Olavarria, Jaime E.; Burzio Menendez, Veronica A.; Burzio Eriz, Luis O., Methods for detecting and treating multiple myeloma.
  218. Poulsen,Tim Svenstrup; Poulsen,Susan Medom; Petersen,Kenneth Heesche, Methods for detecting chromosome aberrations.
  219. Burchard Julja ; Stoughton Roland ; Friend Stephen H., Methods for determining cross-hybridization.
  220. Rigby, Susan; O'Keefe, Heather P.; Stender, Henrik, Methods for determining organisms not requiring the separation of fixative or excess probe.
  221. Gildea, Brian D.; Coull, James M., Methods for modulating the solubility of synthetic polymers.
  222. Achim H. Krotz ; Bethany M. McElroy ; Anthony N. Scozzari, Methods for removing dimethoxytrityl groups from oligonucleotides.
  223. Krotz, Achim H.; McElroy, Bethany M.; Scozzari, Anthony N., Methods for removing dimethoxytrityl groups from oligonucleotides.
  224. Goldstein, Peter H., Methods for sequencing a biomolecule by detecting relative positions of hybridized probes.
  225. Goldstein, Peter H., Methods for sequencing a biomolecule by detecting relative positions of hybridized probes.
  226. Coull James M. ; Hyldig-Nielsen Jens J. ; Godtfredsen Sven E.,DKX ; Fiandaca Mark J. ; Stefano Kyriaki, Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays.
  227. Clarke, Michael F.; Morrison, Sean J.; Wicha, Max S.; Al-Hajj, Muhammad, Methods for targeting solid tumor stem cells in a solid tumor using a notch4 receptor antagonist.
  228. Nadeau, James G.; Verwer, Bernard J. H., Methods for the detection of microorganisms.
  229. Hyldig Nielsen,Jens J.; O'Keefe,Heather P.; Stender,Henrik, Methods for the detection, identification, and/or enumeration of yeast, particularly in wine.
  230. Pieken,Wolfgang; Wolter,Andreas; Leuck,Michael, Methods for the integrated synthesis and purification of oligonucleotides.
  231. Cohen, Robert; Belder-Carr, Suzette; Hagerty, David; Peach, Robert James; Becker, Jean-Claude, Methods for treating Sjogrens syndrome by administering a soluble CTLA4 molecule.
  232. Cohen, Robert; Belder-Carr, Suzette; Hagerty, David; Peach, Robert James; Becker, Jean-Claude, Methods for treating dermatomyositis or polymyositis by administering a soluble CTLA4 molecule.
  233. Cohen, Robert; Belder-Carr, Suzette; Hagerty, David; Peach, Robert James; Becker, Jean-Claude, Methods for treating juvenile rheumatoid arthritis by administering a soluble CTLA4 molecule.
  234. Kole, Ryszard; Collins, Francis S.; Erdos, Michael R.; Cao, Kan, Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA.
  235. Kole, Ryszard; Collins, Francis S.; Erdos, Michael R.; Cao, Kan, Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA.
  236. Cohen, Robert; Belder-Carr, Suzette; Hagerty, David; Peach, Robert James; Becker, Jean-Claude, Methods for treating scleroderma by administering a soluble CTLA4 molecule.
  237. Cohen, Robert; Carr, Suzette; Hagerty, David; Peach, Robert James; Becker, Jean-Claude, Methods for treating type I diabetes mellitus by administering a soluble CTLA4 molecule.
  238. Dahl, Gary A.; Jendrisak, Jerome J.; Radek, Agnes J., Methods for using riboprimers for strand displacement replication of target sequences.
  239. Dahl,Gary A.; Jendrisak,Jerome J.; Radek,Agnes J., Methods for using riboprimers for strand displacement replication of target sequences.
  240. Barak,Lawrence S.; Caron,Marc G.; Ferguson,Stephen S.; Zhang,Jie, Methods of assaying receptor activity.
  241. Barak, Lawrence S.; Caron, Marc G.; Ferguson, Stephen S.; Zhang, Jie, Methods of assaying receptor activity and constructs useful in such methods.
  242. Barak, Lawrence S.; Caron, Marc G.; Ferguson, Stephen S.; Zhang, Jie, Methods of assaying receptor activity and constructs useful in such methods.
  243. Nielsen Peter E.,DKX ; Good Liam,DKX, Methods of bacterial gene function determination using peptide nucleic acids.
  244. Peled, Tony; Fibach, Eitan; Treves, Avi, Methods of controlling proliferation and differentiation of stem and progenitor cells.
  245. Peled, Tony; Fibach, Eitan; Treves, Avi, Methods of controlling proliferation and differentiation of stem and progenitor cells.
  246. Peled,Tony; Fibach,Eitan; Treves,Avi, Methods of controlling proliferation and differentiation of stem and progenitor cells.
  247. Peled,Tony; Fibach,Eitan; Treves,Avi, Methods of controlling proliferation and differentiation of stem and progenitor cells.
  248. Peled, Tony; Steinhardt, Yair, Methods of culturing and expanding mesenchymal stem cells.
  249. Peled, Tony; Treves, Avi; Rosen, Oren, Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby.
  250. Peled,Tony; Treves,Avi; Rosen,Oren, Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby.
  251. Grasso, Luigi; Liang, Shaohong; Nicolaides, Nicholas C.; Sass, Philip M., Methods of generating high-production of antibodies from hybridomas created by in vitro immunization.
  252. Grasso, Luigi; Liang, Shaohong; Nicolaides, Nicholas C.; Sass, Philip M., Methods of generating high-production of antibodies from hybridomas created by in vitro immunization.
  253. Kang, Yibin; Hu, Guohong, Methods of identifying and treating poor-prognosis cancers.
  254. Peled, Tony, Methods of improving stem cell homing and engraftment.
  255. Prakash, Thazha P.; Manoharan, Muthiah, Methods of modulating pharmacokinetics of oligonucleotides.
  256. Gurney, Austin; Lewicki, John; Satyal, Sanjeev H.; Hoey, Timothy, Methods of treating cancer by administering a soluble receptor comprising a human Fc domain and the Fri domain from human frizzled receptor.
  257. Stagg, Robert Joseph; Dupont, Jakob, Methods of treating neuroendocrine tumors using frizzled-binding agents.
  258. Gurney, Austin L.; Sato, Aaron Ken; Axelrod, Fumiko Takada; Hoey, Timothy Charles; Satyal, Sanjeev H.; Mitra, Satyajit Sujit Kumar, Methods of use for an antibody against human frizzled receptors 1, 2. 5, 7 or 8.
  259. Arnold, Jr., Lyle J.; Brown, Bob D., Methods of using oligonucleotides comprising a molecular switch.
  260. Gurney, Austin; Lewicki, John; Satyal, Sanjeev; Hoey, Timothy, Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell.
  261. Coull, James M.; Hyldig-Nielson, Jens J.; Godtfredsen, Sven E.; Fiandaca, Mark J.; Stefano, Kyriaki, Methods, kits and compositions for suppressing the binding of detectable probes to non-target sequences in hybridization assays.
  262. Jack T. Johansen ; Jens J. Hyldig-Nielsen ; Mark J. Fiandaca ; James M. Coull, Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices.
  263. Coull, James M.; Gildea, Brian D.; Hyldig-Nielsen, Jens J., Methods, kits and compositions pertaining to PNA Molecular Beacons.
  264. Coull, James M.; Gildea, Brian D.; Hyldig-Nielsen, Jens J., Methods, kits and compositions pertaining to PNA molecular beacons.
  265. James M. Coull ; Brian D. Gildea ; Jens J. Hyldig-Nielsen, Methods, kits and compositions pertaining to PNA molecular beacons.
  266. Coull, James M.; Fiandaca, Mark J.; Kristjanson, Mark D.; Hyldig Nielsen, Jens J.; Creasey, Theresa S., Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation.
  267. Coull, James M.; Fiandaca, Mark J.; Kristjanson, Mark D.; Hyldig Nielsen, Jens J.; Creasey, Theresa S., Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation.
  268. Coull, James M.; Fiandaca, Mark J.; Kristjanson, Mark D.; Hyldig Nielsen, Jens J.; Creasey, Theresa S., Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation.
  269. Coull, James M.; Fiandaca, Mark J.; Kristjanson, Mark D.; Hyldig-Nielsen, Jens J.; Creasey, Theresa S., Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation.
  270. Coull, James M.; Fiandaca, Mark J.; Kristjanson, Mark D.; Hyldig-Nielsen, Jens J.; Creasey, Theresa S., Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation.
  271. Coull, James M.; Fiandaca, Mark J.; Kristjanson, Mark D.; Hyldig-Nielsen, Jens J.; Creasey, Theresa S., Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation.
  272. Coull, James M.; Fiandaca, Mark J.; Kristjanson, Mark D.; Hyldig-Nielsen, Jens J.; Creasey, Theresa S., Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation.
  273. Coull,James M.; Fiandaca,Mark J.; Kristjanson,Mark D.; Hyldig Nielsen,Jens J.; Creasey,Theresa S., Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation.
  274. Coull, James M.; Gildea, Brian D.; Hyldig-Nielsen, Jens J., Methods, kits and compositions pertaining to detection complexes.
  275. Brian D. Gildea ; James M. Coull ; Jens J. Hyldig-Nielsen ; Mark J. Fiandaca, Methods, kits and compositions pertaining to linear beacons.
  276. Gildea, Brian D.; Coull, James M.; Hyldig-Nielsen, Jens J.; Fiandaca, Mark J., Methods, kits and compositions pertaining to linear beacons.
  277. Brown, Larry R.; Giannoukakis, Nick; Trucco, Massimo, Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes.
  278. Cheung, Ching-Ying; Yue, Stephen; Leung, Wai-Yee, Modified carbocyanine dyes and their conjugates.
  279. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  280. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  281. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  282. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  283. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  284. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  285. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  286. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  287. Leung, Wai-Yee; Cheung, Ching-Ying; Yue, Stephen, Modified carbocyanine dyes and their conjugates.
  288. Bennett, C. Frank; Cowsert, Lex M.; Freier, Susan M., Modulation of CD40 expression.
  289. Bennett, C. Frank; Cowsert, Lex M.; Freier, Susan M., Modulation of CD40 expression.
  290. Dean Nicholas M. ; McKay Robert, Modulation of c-jun using inhibitors of protein kinase C.
  291. Monia, Brett P.; Bhanot, Sanjay; Dobie, Kenneth W.; Jain, Ravi, Modulation of eIF4E-BP1 expression.
  292. Bhanot, Sanjay; Dobie, Kenneth W.; Jain, Ravi, Modulation of eIF4E-BP2 expression.
  293. Bhanot, Sanjay; Dobie, Kenneth W.; Jain, Ravi, Modulation of eIF4E-BP2 expression.
  294. Bhanot,Sanjay; Dobie,Kenneth W.; Jain,Ravi, Modulation of eIF4E-BP2 expression.
  295. Bondarev, Igor E.; Bertram, John S., Modulation of line-1 reverse transcriptase.
  296. Brown-Driver, Vickie L.; Jain, Ravi, Modulation of transthyretin expression.
  297. Freier, Susan M., Modulation of transthyretin expression.
  298. Monia, Brett P.; Freier, Susan M.; Siwkowski, Andrew M.; Guo, Shuling, Modulation of transthyretin expression.
  299. Gurney, Austin L.; Sato, Aaron Ken; Axelrod, Fumiko Takada; Hoey, Timothy Charles; Satyal, Sanjeev H.; Mitra, Satyajit Sujit Kumar, Monoclonal antibodies against frizzled.
  300. Dean, Frank B.; Lasken, Roger S.; Fang, Linhua; Faruqi, A. Fawad; Alsmadi, Osama A.; Driscoll, Mark D.; Hosono, Seiyu, Multiple displacement amplification.
  301. Bornhop, Darryl J., Multiplexed interferometric detection system and method.
  302. Mirkin, Chad A.; Ko, Caroline H.; Stegh, Alexander; Giljohann, David A.; Luciano, Janina; Jensen, Samuel A., Nanoconjugates able to cross the blood-brain barrier.
  303. Chien, Miao-Ping; Gianneschi, Nathan C., Nanofibers and morphology shifting micelles.
  304. Wahlestedt, Claes, Natural antisense and non-coding RNA transcripts as drug targets.
  305. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Miller, Michelle; Bulock, Karen G., Neutral nanotransporters.
  306. Krebber, Anke; Mundorff, Emily; Mock, Marissa; Kambourakis, Spiros, Nitrilase biocatalysts.
  307. Gall, Alexander A.; Kutyavin, Igor V.; Vermeulen, Nicolaas M. J.; Dempcy, Robert O., Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof.
  308. Gall, Alexander A.; Kutyavin, Igor V.; Vermeulen, Nicolaas M. J.; Dempcy, Robert O., Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof.
  309. Taneja, Krishan L., Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair.
  310. Bornhop, Darryl J.; Flowers, Robert A.; Miller, Esther Pesciotta, Nonaqueous backscattering interferometric methods.
  311. Lane Kirk B., Nuclear targeted peptide nucleic acid oligomer.
  312. Lane, Kirk B., Nuclear targeted peptide nucleic acid oligomer.
  313. Hochberg, Avraham; Matouk, Imad, Nucleic acid agents for downregulating H19 and methods of using same.
  314. Hochberg, Avraham; Matouk, Imad, Nucleic acid agents for downregulating H19, and methods of using same.
  315. Lasken, Roger S.; Egholm, Michael; Alsmadi, Osama A., Nucleic acid amplification.
  316. Christopher John Stanley GB; Henrik Orum DK; Mikkel Jorgensen DK, Nucleic acid analogs with a chelating functionality.
  317. Erikson, Glen H.; Daksis, Jasmine I., Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues.
  318. Barak,Larry S.; Oakley,Robert H.; Caron,Marc G.; Laporte,Stephane A.; Wilbanks,Alyson, Nucleic acid encoding G-protein coupled receptor with modified DRY motif.
  319. Mirkin, Chad A.; Giljohann, David A.; Seferos, Dwight, Nucleic acid functionalized nanoparticles for therapeutic applications.
  320. Mirkin, Chad A.; Rosi, Nathaniel L.; Thaxton, C. Shad; Giljohann, David A., Nucleic acid functionalized nanoparticles for therapeutic applications.
  321. Mirkin, Chad A.; Rosi, Nathaniel L.; Thaxton, C. Shad; Giljohann, David A., Nucleic acid functionalized nanoparticles for therapeutic applications.
  322. Mirkin, Chad A.; Rosi, Nathaniel L.; Thaxton, C. Shad; Giljohann, David A., Nucleic acid functionalized nonoparticles for therapeutic applications.
  323. Gurney, Austin; Lewicki, John; Satyal, Sanjeev; Hoey, Timothy, Nucleic acid molecules encoding soluble frizzled (FZD) receptors.
  324. Erikson, Glen H.; Daksis, Jasmine I.; Kandic, Ivana; Picard, Pierre, Nucleic acid multiplex formation.
  325. Lobberding Antonius,DEX ; Mielke Burkhard,DEX ; Schwemler Christoph,DEX ; Schwenner Eckhard,DEX ; Stropp Udo,DEX ; Springer Wolfgang,DEX ; Kretschmer Axel,DEX ; Potter Thorsten,DEX, Nucleic acid-binding oligomers possessing C-branching for therapy and diagnostics.
  326. Cook, Phillip Dan, Nucleobase heterocyclic combinatorialization.
  327. Andrei P. Guzaev ; Phillip Dan Cook ; Muthiah Manoharan ; Balkrishen Bhat, Nucleosidic and non-nucleosidic folate conjugates.
  328. Cook, Phillip Dan; Manoharan, Muthiah; Bhat, Balkrishen; Guzzaev, Andrei P., Nucleosidic and non-nucleosidic folate conjugates.
  329. Ayalon-Soffer, Michal; Pollock, Sarah; Shemesh, Ronen; Sorek, Rotem; Levine, Zurit; Shaqed, Zipi; Toporik, Amir; Cojocaru, Gad S.; Dahary, Dvir; Kol, Guy; Akiva, Pinchas; Novik, Amit; Nemzer, Sergey; Diber, Alexander; Shklar, Maxim; Sella-Tavor, Osnat; Bazak, Lily; Farkash, Ariel; Cohen, Yossi, Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis.
  330. Esau, Christine; Swayze, Eric E.; Bhat, Balkrishen; Kinberger, Garth A., Oligomeric compounds and compositions for the use in modulation of microRNAs.
  331. Esau, Christine; Swayze, Eric E.; Bhat, Balkrishen; Kinberger, Garth A., Oligomeric compounds and compositions for the use in modulation of micrornas.
  332. Esau, Christine; Swayze, Eric E.; Bhat, Balkrishen; Kinberger, Garth A., Oligomeric compounds and compositions for the use in modulation of target nucleic acids.
  333. Hanson, Gunnar J.; Rudolph, Alexander Charles; Cai, Bao Zhong; Zhou, Ming; Weller, Dwight D., Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups.
  334. Hanson, Gunnar J.; Rudolph, Alexander Charles; Cai, Bao Zhong; Zhou, Ming; Weller, Dwight D., Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups.
  335. Hanson, Gunnar J.; Rudolph, Charles; Cai, Bao Zhong; Zhou, Ming; Weller, Dwight D., Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups.
  336. Kole, Ryszard; Bestwick, Richard Keith, Oligonucleotide analogues targeting human LMNA.
  337. Kole, Ryszard; Bestwick, Richard Keith, Oligonucleotide analogues targeting human LMNA.
  338. Kole, Ryszard; Bestwick, Richard Keith, Oligonucleotide analogues targeting human LMNA.
  339. Efimov, Vladimir; Fernandez, Joseph; Archdeacon, Dorothy; Archdeacon, John; Chakhmakhcheva, Oksana; Buryakova, Alla; Choob, Mikhail; Hondorp, Kyle, Oligonucleotide analogues, methods of synthesis and methods of use.
  340. Bennett C. Frank ; Vickers Timothy A., Oligonucleotide compositions and methods for the modulation of the expression of B7 protein.
  341. Bennett C. Frank ; Vickers Timothy A., Oligonucleotide compositions and methods for the modulation of the expression of B7 protein.
  342. Bennett, C. Frank; Freier, Susan M, Oligonucleotide compositions and methods for the modulation of the expression of B7 protein.
  343. Bennett,C. Frank; Vickers,Timothy A.; Karras,James G.; Freier,Susan M., Oligonucleotide compositions and methods for the modulation of the expression of B7 protein.
  344. Damha, Masad J.; Watts, Jonathan K.; Deleavey, Glen, Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof.
  345. Damha, Masad J.; Watts, Jonathan K.; Deleavey, Glen, Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof.
  346. Bennett, C. Frank; Dean, Nicholas M.; Holmlund, Jon T.; Dorr, F. Andrew, Oligonucleotide inhibition of protein kinase C.
  347. Brown, Bob D.; Riley, Timothy A., Oligonucleotide probes and primers comprising universal bases for diagnostic purposes.
  348. Moore,Max N.; Andrade,Mark; Carty,Recaldo; Scozzari,Anthony; Krotz,Achim, Oligonucleotide synthesis with alternative solvents.
  349. Cook, Phillip Dan; Manoharan, Muthiah; Bhat, Balkrishen, Oligonucleotide-folate conjugates.
  350. Arnold, Jr., Lyle J.; Brown, Bob D., Oligonucleotides comprising a molecular switch.
  351. Damha, Masad J.; Parniak, Michael A., Oligonucleotides comprising alternating segments and uses thereof.
  352. Damha, Masad J.; Parniak, Michael A., Oligonucleotides comprising alternating segments and uses thereof.
  353. Manoharan, Muthiah, Oligonucleotides conjugated to protein-binding drugs.
  354. Bennett C. Frank ; Dean Nicholas M., Oligonucleotides for enhanced modulation of protein kinase C expression.
  355. Kauppinen, Sakari; Alsbo, Carsten; Nielsen, Peter S.; Jeffares, Daniel C.; Mourier, Tobias; Mørk, Søren; Arctander, Peter; Tommerup, Niels; Tolstrup, Niels; Vissing, Henrik; Echwald, Søren Morgenthaler, Oligonucleotides useful for detecting and analyzing nucleic acids of interest.
  356. Crooke, Stanley T., Oligoribonucleotides and ribonucleases for cleaving RNA.
  357. Bailey, Ryan C.; Qavi, Abraham J.; Kindt, Jared T.; Byeon, Ji-Yeon; Luchansky, Matthew S.; McClellan, Melinda S.; Washburn, Adam L.; Owen, Tate; Gleeson, Martin Anthony; Gunn, III, Lawrence C., Optical analyte detection systems and methods of use.
  358. Lugade, Ananda G.; Jacobson, James W., Oxocarbonamide peptide nucleic acids and methods of using same.
  359. Beavo, Joseph A.; Seebeck, Thomas; Soderling, Scott Haydn; Rascon, Ana; Zoraghi, Roya; Kunz, Stefan; Gong, Kewei; Glavas, Natalie, PDEs and uses thereof.
  360. Beavo,Joseph A.; Seebeck,Thomas; Soderling,Scott Haydn; Rascon,Ana; Zoraghi,Roya; Kunz,Stefan; Gong,Kewei; Glavas,Natalie, PDEs and uses thereof.
  361. Glahn et al., PNA diagnostic methods.
  362. Stender, Henrik; Hyldig-Nielsen, Jens J., PNA oligomers, oligomer sets, methods and kits pertaining to the detection of .
  363. Breipohl Gerhard,DEX ; Uhlmann Eugen,DEX ; Knolle Jochen,DEX, PNA synthesis using a base-labile amino protecting group.
  364. Breipohl Gerhard,DEX ; Uhlmann Eugen,DEX ; Knolle Jochen,DEX, PNA synthesis using a base-labile amino protecting group.
  365. Cook Phillip Dan, PNA-DNA-PNA chimeric macromolecules.
  366. Erikson, Glen H.; Daksis, Jasmine I.; Kandic, Ivana; Picard, Pierre, Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes.
  367. Erikson,Glen H.; Daksis,Jasmine I.; Kandic,Ivana; Picard,Pierre, Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes.
  368. Mirkin, Chad A.; Seferos, Dwight S.; Giljohann, David A., Particles for detecting intracellular targets.
  369. Mirkin, Chad A.; Seferos, Dwight; Giljohann, David A., Particles for detecting intracellular targets.
  370. Nielsen,Peter; Buchardt,Ole; Sonnechsen,Soren Holst; Lohse,Jesper; Egholm,Michael; Manoharan,Muthiah; Kiely,John; Griffith,Michael; Sprankle,Kelly, Peptide nucleic acid conjugates.
  371. Nielsen, Peter E.; Haaima, Gerald; Eldrup, Anne B., Peptide nucleic acid monomers and oligomers.
  372. Nielsen, Peter E.; Haaima, Gerald; Eldrup, Anne B., Peptide nucleic acid monomers and oligomers.
  373. Andrew P. Patron ; Azra Pervin, Peptide nucleic acid precursors and methods of preparing same.
  374. Stender, Henrik, Peptide nucleic acid probes for detection, identification and/or quantitation of Pseudomonas (sensu stricto).
  375. Buchardt, Ole; Egholm, Michael; Nielsen, Peter Eigil; Berg, Rolf Henrik, Peptide nucleic acid synthons.
  376. Michael Egholm ; Peter Nielsen DK; Ole Buchardt DK; Kim L. Dueholm DK; Leif Christensen DK; James M. Coull ; John Kiely ; Michael Griffith, Peptide nucleic acids.
  377. Ole Buchardt DK; Michael Egholm DK; Peter Eigil Nielsen DK; Rolf Henrik Berg DK, Peptide nucleic acids.
  378. Buchardt, Ole; Egholm, Michael; Nielsen, Peter Eigil; Berg, Rolf Henrik, Peptide nucleic acids having 2,6-diaminopurine nucleobases.
  379. Ole Buchardt DE; Michael Egholm ; Peter Eigil Nielsen DK; Rolf Henrik Berg DK, Peptide nucleic acids having 2,6-diaminopurine nucleobases.
  380. Nielsen, Peter E.; Good, Liam, Peptide nucleic acids having antibacterial activity.
  381. Nielsen, Peter E.; Egholm, Michael; Berg, Rolf H.; Buchardt, Ole; Buchardt, Dorte, Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility.
  382. Buchardt,Ole; Egholm,Michael; Nielsen,Peter Eigil; Berg,Rolf Henrik, Peptide nucleic acids with polyamide-containing backbones.
  383. Anantharamaiah, Gattadahalli M.; Fogelman, Alan M.; Navab, Mohamad; Rudolf, Martin, Peptides and peptide mimetics to treat pathologies associated with eye disease.
  384. Chinnaiyan, Arul M.; Wang, Xiaoju, Phage microarray profiling of the humoral response to disease.
  385. Chinnaiyan, Arul; Wang, Xiaoju, Phage microarray profiling of the humoral response to disease.
  386. Klaerner, Gerrit; Nielsen, Ralph B.; Mansky, Paul; Benoit, Didier; Charmot, Dominique; Jandeleit, Bernd; Mazzola, Laura T., Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto.
  387. Klaerner,Gerrit; Benoit,Didier; Charmot,Dominique; Nomula,Srinivas; Piotti,Marcelo Eduardo; Mazzola,Laura T., Polymer brushes for immobilizing molecules to a surface or substrate having improved stability.
  388. Klaerner, Gerrit; Nielsen, Ralph B.; Mansky, Paul; Benoit, Didier; Charmot, Dominique; Jandeleit, Bernd; Mazzola, Laura T., Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto.
  389. Cheng Peter C. ; Albagli David ; Wood Michael L., Polynucleotide crosslinking agents.
  390. Gu, Yizhong; Ji, Yonggang; Penn, Sharron Gaynor; Hanzel, David Kagen; Rank, David Russell; Chen, Wensheng; Shannon, Mark E., Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle.
  391. Hogan, James J., Polynucleotide matrix-based method of identifying microorganisms.
  392. Hogan James J. ; Gordon Patricia, Polynucleotide probes for detection and quantitation of actinomycetes.
  393. Hogan James J. ; Gordon Patricia, Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae.
  394. James J. Hogan ; Patricia Gordon, Polynucleotide probes for detection and quantitation of staphylococcus.
  395. Dent, Joseph Alan; Putrenko, Igor, Polynucleotides encoding acetylcholine-gated chloride channel subunits of.
  396. Gurney, Austin L.; Sato, Aaron Ken; Axelrod, Fumiko Takada; Hoey, Timothy Charles; Satyal, Sanjeev H.; Mitra, Satyajit Sujit Kumar, Polynucleotides encoding for frizzled-binding agents and uses thereof.
  397. Hauser, Todd M., Polynucleotides for multivalent RNA interference, compositions and methods of use thereof.
  398. Hauser, Todd M., Polynucleotides for multivalent RNA interference, compositions and methods of use thereof.
  399. Cohen-Dayag, Anat; Beiman, Merav; Dassa, Liat; Bubis, Marina; Greenwald, Shirley Sameach-; Landesman-Milo, Dalit; Koifman, Cynthia; Levy, Ofer; Nemzer, Sergey; Pergam, Tania; Kinar, Yaron; Levine, Zurit; Rosenberg, Avi; Rotman, Galit; Montia, Eve; Novik, Amit; Toporik, Amir; Walach, Shira, Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics.
  400. Levine, Zurit; Pergam, Tania; Landesman-Milo, Dalit; Cohen-Dayag, Anat; Toporik, Amir; Kinar, Yaron; Nemzer, Sergey; Rosenberg, Avi; Rotman, Galit; Novik, Amit; Koifman, Cynthia; Beiman, Merav; Dassa, Liat; Walach, Shira; Montia, Eve; Sameach-Greenwald, Shirley; Levy, Ofer; Bubis, Marina, Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics.
  401. Levine, Zurit; Toporik, Amir; Novik, Amit; Cohen-Dayag, Anat; Rosenberg, Avi; Koifman, Cynthia; Landesman-Milo, Dalit; Montia, Eve; Rotman, Galit; Dassa, Liat; Bubis, Marina; Beiman, Merav; Levy, Ofer; Nemzer, Sergey; Walach, Shira; Greenwald, Shirley Sameach-; Pergam, Tania; Kinar, Yaron, Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics.
  402. Toporik, Amir; Novik, Amit; Cohen-Dayag, Anat; Rosenberg, Avi Yeshah; Koifman, Cynthia; Landesman-Milo, Dalit; Montia, Eve; Rotman, Galit; Dassa, Liat; Bubis, Marina; Beiman, Merav; Levi, Ofer; Nemzer, Sergey; Pergam, Tania; Kinar, Yaron; Greenwald, Shirley Sameach-; Levine, Zurit; Walach, Shira, Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics.
  403. Toporik, Amir; Novik, Amit; Cohen-Dayag, Anat; Rosenberg, Avi Yeshah; Koifman, Cynthia; Landesman-Milo, Dalit; Montia, Eve; Rotman, Galit; Dassa, Liat; Bubis, Marina; Beiman, Merav; Levy, Ofer; Nemzer, Sergey; Pergam, Tania; Kinar, Yaron; Sameach-Greenwald, Shirley; Levine, Zurit; Walach, Shira, Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics.
  404. Toporik, Amir; Rosenberg, Avi Yeshah; Rotman, Galit; Hecht, Iris; Levine, Zurit, Polypeptides and uses thereof for treatment of autoimmune disorders and infection.
  405. Mirkin, Chad A.; Giljohann, David A.; Seferos, Dwight S.; Prigodich, Andrew E.; Patel, Pinal C., Polyvalent RNA-nanoparticle compositions.
  406. Mirkin, Chad A.; Giljohann, David A.; Seferos, Dwight; Prigodich, Andrew E.; Patel, Pinal C., Polyvalent RNA-nanoparticle compositions.
  407. Bhat, Balkrishen; Swayze, Eric E.; Prakash, Thazha P.; Allerson, Charles; Dande, Prasad; Griffey, Richard H., Positionally modified siRNA constructs.
  408. Frezza, Brian M.; Webster, Courtney E.; Kleinbaum, Daniel J., Preparation of oligo conjugates.
  409. Hogan,James J., Probe matrix-based device for identifying microorganisms.
  410. Scozzari Anthony, Process for oligonucleotide synthesis.
  411. Ross Bruce S. ; Manoharan Muthiah, Process for the synthesis of oligonucleotides incorporating 2-aminoadenosine.
  412. Stanley Christopher John,GB3 ; Orum Henrik,DKX ; Jorgensen Mikkell,DKX ; Basboll Ole,DKX, Protecting nucleic acids and methods of analysis.
  413. Song,Quanlai; Ross,Bruce S., Protection of nucleosides.
  414. Glazer, Peter M., Pseudocomplementary oligonucleotides for targeted gene therapy.
  415. Atkinson,Ian J.; Erikson,Glen H.; Daksis,Jasmine I.; Picard,Pierre, Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism.
  416. Wu Yuan Min,CAX ; Nie Eileen Xiao-Feng,CAX, Quantitative method for detecting nucleotide concentration.
  417. Disney, Matthew D., RNA targeting compounds and methods for making and using same.
  418. Disney, Matthew David, RNA targeting compounds and methods for making and using same.
  419. Wooddell, Christine I.; Rozema, David B.; Lewis, David L.; Wakefield, Darren H.; Almeida, Lauren J., RNAi Therapy for Hepatitis B Virus Infection.
  420. Liu, David R.; Kanan, Matthew William; Rozenman, Mary M., Reaction discovery system.
  421. Corona, Cesear; Klaubert, Dieter; McDougall, Mark, Reactive cyanine compounds.
  422. 19340400 ; Wendt et al., Reagent and method for isolation and detection of selected nucleic acid sequences.
  423. Fiandaca, Mark; Stender, Henrik, Reagents, methods and kits for classification of fungi and direction of anti-fungal therapy.
  424. Albino, Anthony P.; Jin, Wendy; Jorgensen, Ellen, Reduced risk tobacco products and methods of making same.
  425. Korfhage, Christian; Peist, Ralf; Löffert, Dirk, Reverse transcription and amplification of RNA with simultaneous degradation of DNA.
  426. Carey,Indira; Heiland,Teri; Smith,Anna; Ray,Jill, Reversible association of nucleic acid with a carboxylated substrate.
  427. Spudich, James A.; Nock, Steffen; Wagner, Peter, Reversible immobilization of arginine-tagged moieties on a silicate surface.
  428. Breaker, Ronald R.; Nahvi, Ali; Sudarsan, Narasimhan; Ebert, Margaret S.; Winkler, Wade; Barrick, Jeffrey E.; Wickiser, John K., Riboswitches, methods for their use, and compositions for use with riboswitches.
  429. Breaker, Ronald R.; Nahvi, Ali; Sudarsan, Narasimhan; Ebert, Margaret S.; Winkler, Wade; Barrick, Jeffrey E.; Wickiser, John K., Riboswitches, methods for their use, and compositions for use with riboswitches.
  430. Bornhop, Darryl J.; Kammer, Michael, Robust interferometer and methods of using same.
  431. Kumar, Gyanendra; Abarz?a, Patricio, Rolling circle amplification of RNA.
  432. Lizardi, Paul M., Rolling circle replication reporter systems.
  433. Kilpatrick, Daniel; Wang, Hang, SREBP2gc transcription factors and uses thereof.
  434. Myers,Andrew G.; Plowright,Alleyn T., Saframycins, analogues and uses thereof.
  435. Mirkin, Chad A.; Hurst, Sarah J.; Han, Min Su; Lytton-Jean, Abigail K. R., Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay.
  436. West, Jason Andrew Appleton; Satterfield, Brent Coleman, Selection of aptamers based on geometry.
  437. Rey, Diego Ariel, Sequence-specific detection and phenotype determination.
  438. Barak, Lawrence S.; Shetzline, Michael A.; Oakley, Robert H.; Caron, Marc G., Single-cell biosensor for the measurement of GPCR ligands in a test sample.
  439. Wu Yuan Min,CAX ; Nie Eileen Xiao-Feng,CAX, Solution hybridization of nucleic acids with antisense probes having modified backbones.
  440. Anantharamaiah, Gattadahalli M.; Garber, David W.; Datta, Geeta; Handattu, Sheila P.; Mishra, Vinod K., Synthetic apolipoprotein E mimicking polypeptides and methods of use.
  441. Anantharamaiah, Gattadahalli M.; White, C. Roger; Gupta, Himanshu, Synthetic apolipoprotein E mimicking polypeptides and methods of use.
  442. Gildea Brian D. ; Coull James M., Synthetic polymers and methods, kits or compositions for modulating the solubility of same.
  443. Buchardt, Ole; Buchardt, D.; Egholm, Michael; Nielsen, Peter Eigil; Berg, Rolf Henrik, Synthetic procedures for peptide nucleic acids.
  444. Cowsert,Lex M.; Baker,Brenda F.; McNeil,John; Freier,Susan M.; Sasmor,Henri M.; Brooks,Douglas G.; Ohashi,Cara; Wyatt,Jacqueline R.; Borchers,Alexander H.; Vickers,Timothy A., System of components for preparing oligonucleotides.
  445. Goldstein, Peter; Preparata, Franco; Upfal, Eli, Tagged-fragment map assembly.
  446. Manoharan, Muthiah, Targeted Oligonucleotide conjugates.
  447. Manoharan Muthiah, Targeted oligonucleotide conjugates.
  448. Manoharan, Muthiah, Targeted oligonucleotide conjugates.
  449. List, Alan; Wei, Sheng, Targeted sensitization of non-del(5q) malignant cells.
  450. Donald, Carlton D., Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy.
  451. Donald, Carlton D., Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy.
  452. Donald, Carlton D., Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy.
  453. Donald, Carlton D., Targeting PAX2 for the treatment of breast cancer.
  454. Donald, Carlton D., Targeting PAX2 for the treatment of breast cancer.
  455. Donald, Carlton D., Targeting PAX2 for the treatment of breast cancer.
  456. Donald, Carlton D., Targeting PAX2 for the treatment of breast cancer.
  457. Mirkin, Chad A.; Giljohann, David A.; Daniel, Weston L.; Cutler, Joshua I.; Zhang, Ke; Zheng, Dan, Templated nanoconjugates.
  458. Mirkin, Chad A.; Giljohann, David A.; Daniel, Weston L.; Cutler, Joshua I.; Zhang, Ke; Zheng, Dan, Templated nanoconjugates.
  459. Faghihi, Mohammad Ali; Coito, Carlos, Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF.
  460. Hanash, Samir M.; Rickman, David; Tyagi, Rachana; Zhu, Xiao-Xiang; Kish, Phillip, Treatments and markers for cancers of the central nervous system.
  461. Erikson, Glen H.; Daksis, Jasmine I., Triplex and quadruplex catalytic hybridization.
  462. Abarzúa, Patricio; Smelkova, Natalia; Sparkowski, Jason, Universal reagents for rolling circle amplification and methods of use.
  463. Ling, Xinsheng; Bready, Barrett; Oliver, John S.; Jouzi, Maryam; Petrossian, Leo, Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels.
  464. Oliver, John S.; Tang, Jing, Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels.
  465. Ole Buchardt DK; Michael Egholm DK; Peter E. Nielsen DK; Rolf H. Berg DK, Use of nucleic acid analogues in diagnostics and analytical procedures.
  466. Chinnaiyan, Arul M.; Wang, Xiaoju; Tsodikov, Alex; Ohrnberger, Jeanne, Using phage epitopes to profile the immune response.
  467. Elliott Richelson ; Beth Marie Tyler ; Daniel J. McCormick ; Bernadette Marie Cusack ; Clark V. Hoshall ; Christopher Lee Douglas ; Karen Jansen, Using polyamide nucleic acid oligomers to engender a biological response.
  468. Richelson, Elliott; Tyler, Beth Marie; Cusack, Bernadette Marie; Douglas, Christopher Lee; Jansen, Karen, Using polyamide nucleic acid oligomers to engender a biological response.
  469. Richelson, Elliott; Tyler, Beth Marie; McCormick, Daniel J.; Cusack, Bernadette Marie; Hoshall, Clark V.; Douglas, Christopher Lee; Jansen, Karen, Using polyamide nucleic acid oligomers to engender a biological response.
  470. Richelson,Elliott; Tyler,Beth Marie; Cusack,Bernadette Marie; Douglas,Christopher Lee; Jansen,Karen, Using polyamide nucleic acid oligomers to engender a biological response.
  471. Satyal, Sanjeev H.; Mitra, Satyajit Sujit Kumar; Gurney, Austin L., Wnt antagonist and methods of treatment and screening.
  472. Satyal, Sanjeev H.; Mitra, Satyajit Sujit Kumar; Gurney, Austin L., Wnt antagonists and methods of treatment and screening.
  473. Iversen, Patrick L., dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups.
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