[특허]Isolated antigenic oncogene peptide fragments and uses

[미국특허] Isolated antigenic oncogene peptide fragments and uses 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/08 C07K-004/12
출원번호	US-0195075 (1994-02-10)
발명자 / 주소	Eberlein Timothy J. (Dover MA) Peoples George E. (Newtonville MA) Yoshino Ichiro (Brookline MA) Goedegebuure Peter (Brighton MA)
출원인 / 주소	Brigham and Women\s Hospital (Boston MA 02)
인용정보	피인용 횟수 : 40 인용 특허 : 0

초록 ▼

An isolated antigenic peptide fragment that is an isolated oncogene protein fragment is disclosed. The isolated peptide fragment of the invention is a peptide either 9 or 10 amino acid residues in length that includes at least a leucine residue at the C- terminus (i.e., position 9 or position 10). The peptide fragment is capable of binding in an HLA-A2 binding cleft and is capable of stimulating proliferation of at least one tumor-specific cytotoxic T-lymphocyte. Preferred peptides further include an isoleucine residue at position 2 and a valine residue at position 6. The most preferred isolated peptides can stimulate proliferation of cytotoxic T-lymphocytes obtainable from peripheral blood lymphocytes, ovarian tumors, breast tumors, gastric tumors, non-small cell lung tumors, pancreatic tumors, colon tumors, gliomas, bladder tumors, endometrial tumors and neuroblastomas. The preferred isolated peptide of the invention is a mutant peptide defined by SEQ ID NO.:2 or its functional equivalents. Isolated cytotoxic T-lymphocytes capable of recognizing isolated peptides of the invention, particularly the HER2/neu mutant peptide are disclosed. These lymphocytes are especially useful for killing tumors or other cells which present on their surfaces the antigenic peptides of the invention. In particular, the lymphocytes are obtainable from ovarian tumor cells, breast tumor cells and non-small-cell lung tumor cells. A method of stimulating proliferation of tumor-specific cytotoxic T-lymphocytes is described. This method includes obtaining lymphocytes from tumor tissue and contacting the lymphocytes with a peptide of the invention under conditions sufficient for the cytotoxic T-lymphocytes to proliferate. Therapeutically effective compositions containing the HER2/neu peptides are also described.

대표청구항

An isolated peptide consisting of 10 amino acid residues, said isolated peptide having an amine acid sequence consisting of IISAVVGILN, where N is an amine acid selected from the group consisting of L, V, and I.

이 특허를 인용한 특허 (40) 인용/피인용 타임라인 분석

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Wallen Erik S. ; Moseley Pope L., Methods for synthesizing heat shock protein complexes.
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Erik Wallen ; Pope L. Moseley, Methods for using heat shock proteins.
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Kokichi Kikuchi JP; Noriyuki Sato JP; Hiromitsu Sahara JP; Takahiro Yasojima JP; Yoshimasa Wada JP; Manabu Suzuki JP; Junji Hamuro JP, Peptide capable of inducing immune response to human gastric cancer and agent for preventing or treating human gastric cancer, containing the peptide.
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Kast,Wybe Martin; Melief,Cornelis Joseph Maria; Sette,Alessandro D.; Sidney,John C., Peptides of human Papilloma virus for use in human T cell response inducing compositions.
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Majumdar, Adhip P. N., Recombinant DNA encoding an epidermal growth factor receptor related protein.
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Ponniah, Sathibalan; Peoples, George E.; Storrer, Catherine E.; Flora, Michael, Stable quantitation and detection of immune response levels with non-zero background peptides.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Isolated antigenic oncogene peptide fragments and uses 원문보기