[특허]Method and apparatus for cell counting and cell classification

Method and apparatus for cell counting and cell classification 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/53
출원번호	US-0236645 (1994-05-02)
발명자 / 주소	Sizto Ning L. (Freemont CA) Dietz Louis J. (Mountain View CA)
출원인 / 주소	Biometric Imaging, Inc. (Mountain View CA 02)
인용정보	피인용 횟수 : 107 인용 특허 : 0

초록 ▼

A method and an apparatus for analyzing a material within a container, such as blood within a capillary in a volumetric cytometry system provides for detecting the edges of the container, counting the cells within the container, characterizing the cells within the container, and evaluating channels of data which contain information relevant to more than one of the detectable characteristics of the cells. A scanner scans a container of material including certain cells. Sampling circuitry is coupled to the scanner to generate scanned images of the material in the container. Two or more scanned images are generated based on fluorescence data from dyes that have overlapping spectra. The two scanned images are processed using a linear regression analysis among corresponding pixels in the scanned images near certain cells to characterize relative contents of two fluorescing dyes in a target cell. Target cells are identified from the scanned images using processing resources which identify a peak sample within a neighborhood, and compare the amplitude of the peak with the amplitude of pixels on the perimeter of the neighborhood. Upon identifying a target cell in this manner, data from the plurality of scanned images corresponding to the identified cell are saved for further analysis.

대표청구항 ▼

A method for analyzing a sample containing cells to detect and characterize target cells having first detectable characteristics and second detectable characteristics in a fixed volume capillary that contains a fluorescent background which exhibits background characteristics, the method comprising: scanning the fixed volume capillary containing the sample to generate a first channel of data and a second channel of data, wherein the first channel of data includes the first detectable characteristics and first background characteristics and the second channel of data includes the second detectable characteristics and second background characteristics; sampling the first and the second channels of data to produce corresponding first and second sets of pixel values; loading the first and the second sets of pixel values into a pixel map buffer; analyzing the first and the second sets of pixel values in the pixel map buffer to identify a peak event indicative of the target cell; saving a first neighborhood of pixel values from the first set of pixel values and a second neighborhood of pixel values from the second set of pixel values for the peak event; performing linear regression to correct for detection of the second detectable characteristics in the first channel and for detection of the first detectable characteristics in the second channel; filtering the first neighborhood of pixel values and the second neighborhood of pixel values for the peak event using predetermined peak characteristic so as to adjust for the first and the second background characteristics; generating a first intensity value from the first neighborhood and a second intensity value from the second neighborhood for the peak event; and comparing the first intensity value and the second intensity value for the peak event to a first threshold to classify the target cell.

이 특허를 인용한 특허 (107)

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Ivosevic, Milan; Bokka Srinivasa Rao, Kishore K.; Skutnik, Peter; Torris, Anthony V., Biological fluid micro-sample management device.
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Dietz Louis J. (Mountain View CA) Baer Thomas M. (Mountain View CA), Calibration method and apparatus for optical scanner.
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Evans, Kenneth M., High resolution flow cytometer.
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Burbaum Jonathan J. ; Chung Thomas D.Y. ; Kirk Gregory L. ; Inglese James ; Chelsky Daniel, High-throughput assay.
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Krahn,Thoams; Paffhausen,Wolfgang; Schade,Andreas; Bechem,Martin; Schmidt,Delf, Masking background flourescence and luminescence in optical analysis of biomedical assays.
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Krahn, Thomas; Paffhausen, Wolfgang; Schade, Andreas; Bechem, Martin; Schmidt, Delf, Masking background fluorescence and luminescence in the optical analysis of biomedical assays.
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Krahn, Thoams; Paffhausen, Wolfgang; Schade, Andreas; Bechem, Martin; Schmidt, Delf, Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays.
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Krahn,Thomas; Paffhausen,Wolfgang; Schade,Andreas; Bechem,Martin; Schmidt,Delf, Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays.
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Albrecht, Glenn; Brenner, Sydney; DuBridge, Robert B.; Lloyd, David H.; Pallas, Michael C., Massively parallel signature sequencing by ligation of encoded adaptors.
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Prisbrey, Landon; Blackmore, Elise; Hance, Kenneth R.; Metzger, Steven W.; Marshall, Kevin, Membrane-assisted purification.
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Durack, Gary; Wallace, Jeffrey D.; Vandre, Gary P.; Westfall, Lon A.; Hatcher, Jeremy T.; Nayak, Niraj V., Method and apparatus for calibrating a flow cytometer.
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Timothy D. Harris ; Richard L. Hansen ; William Karsh ; Neal A. Nicklaus ; Jay K. Trautman, Method and apparatus for screening chemical compounds.
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Im, Hyo Hyuc; Choi, Kyu Young; Lee, Yeong Jin; Song, Tae Yoon, Method for detecting microorganism having fluorescent characteristics with respect to specific wavelength.
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Wyant, Timothy L.; Raju, Paul A.; Kantor, Aaron B., Method for monitoring resting and activated platelets in unfixed blood samples.
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Wyant,Timothy L.; Raju,Paul A.; Kantor,Aaron B., Method for monitoring resting and activated platelets in unfixed blood samples.
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Bridgham, John; Corcoran, Kevin; Golda, George; Pallas, Michael C.; Brenner, Sydney, Method for sequential sequencing nucleic acids.
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Davis Kenneth A., Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells.
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Wu, Yuan-Jye; Tat, Hong; Koltenbah, Benjamin E. C.; Wu, Vicki, Methods and systems for inspection of composite irregularities.
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Chee, Mark S.; Stuelpnagel, John R.; Czarnik, Anthony W., Multiplex decoding of array sensors with microspheres.
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Sharpe, Jonathan C.; Schaare, Peter N., Optical apparatus.
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Dietz, Louis J.; Walton, Ian; Norton, Scott, Optical architectures for microvolume laser-scanning cytometers.
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Dietz, Louis J.; Walton, Ian; Norton, Scott, Optical architectures for microvolume laser-scanning cytometers.
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Dietz, Louis J.; Walton, Ian; Norton, Scott, Optical architectures for microvolume laser-scanning cytometers.
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Bala S. Manian ; David M. Heffelfinger ; Edward M. Goldberg, Optical autofocus for use with microtiter plates.
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Manian Bala S. ; Heffelfinger David M. ; Goldberg Edward M., Optical autofocus for use with microtiter plates.
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Horchner,Uwe; Kantor,Aaron B., Polychronic laser scanning system and method of use.
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Metzger, Steven W.; Hance, Kenneth Robert, Rapid cell purification systems.
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Metzger, Steven W.; Hance, Kenneth Robert, Rapid cell purification systems.
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Metzger, Steven W.; Hance, Kenneth Robert, Rapid cell purification systems.
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Metzger, Steven W.; Howson, David C.; Goldberg, David A.; Buttry, Daniel A., Rapid microbial detection and antimicrobial susceptibility testing.
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Grimes,Steve; Haubert,Thomas D.; Navin,Eric R., Sample tube handling apparatus.
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Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
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Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
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Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
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Seidel, George E.; Lu, Kehuan; Suh, Tae Kwang; Cran, David G., Separation systems of frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations.
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Schenk, John L.; Seidel, George E.; Suh, Tae Kwang, Sex selected equine embryo production system.
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Ludwig, Cindy L.; Crowley, Kathleen S.; Graves, Charles N., Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations.
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Bridgham, John; Corcoran, Kevin; Golda, George; Pallas, Michael C.; Brenner, Sydney, System and apparatus for sequential processing of analytes.
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Heffelfinger, David M.; Schiffman, Aram P.; Manian, Bala S., System for high throughput analysis.
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Dietz, Louis J.; Walton, Ian; Chung, Chih-Hua; Norton, Scott; Winkler, James L.; Kantor, Aaron B.; Lee, Byron; Tsur, Shalom, System for microvolume laser scanning cytometry.
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Dietz,Louis J; Walton,Ian; Chung,Chih Hua; Norton,Scott; Winkler,James L; Kantor,Aaron B; Lee,Byron; Tsur,Shalom, System for microvolume laser scanning cytometry.
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A62	인명구조; 소방(사다리 E06C)
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Method and apparatus for cell counting and cell classification 원문보기

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Method and apparatus for cell counting and cell classification 원문보기

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