초록 ▼

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, hav

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. The apparatus can be adapted to manual, semiautomatic or fully automatic performance. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.

대표청구항 ▼

An apparatus for multiple, simultaneous synthesis of compounds comprising: a plurality of reaction tubes, each reaction tube having an upper end and a lower end, said lower ends each having a filter device, a reservoir member having means for receiving the filter devices on the lower ends of said pl

An apparatus for multiple, simultaneous synthesis of compounds comprising: a plurality of reaction tubes, each reaction tube having an upper end and a lower end, said lower ends each having a filter device, a reservoir member having means for receiving the filter devices on the lower ends of said plurality of reaction tubes, a holder member removably located adjacent to the reservoir member having a plurality of apertures for supporting said plurality of reaction tubes, and a manifold member having a central cavity for enclosing the upper ends of said plurality of reaction tubes, said manifold member having a top wall member, said top wall member having a plurality of apertures which are coaxial with the plurality of apertures in said holder member, wherein access is possible independently to each of said reaction tubes through said top wall member.