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Erosion rate modifier for use in bioerodible drug delivery devices and method of use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
출원번호 US-0307845 (1994-09-30)
국제출원번호 PCT/US93/03003 (1993-03-30)
§371/§102 date 19940930 (19940930)
국제공개번호 WO-9320134 (1993-10-14)
발명자 / 주소
  • Roorda Wouter E. (Newark CA) Ehnow Fred (Mountain View CA)
출원인 / 주소
  • Alza Corporation (Palo Alto CA 02)
인용정보 피인용 횟수 : 29  인용 특허 : 20

초록

This invention resides in the field of bioerodible polymers for use as drug delivery vehicles. In particular, this invention addresses means for controlling the rate of biodegradation and degradation in general of such polymers.

대표청구항 ▼

A method for altering the erosion rate of a drug-containing bioerodible composition to obtain a predetermined rate of drug release therefrom, said composition comprising a polymer selected from the group consisting of polymers and copolymers of d,l-lactic and glycolic acids and mixtures thereof, sai

이 특허에 인용된 특허 (20)

  1. Himmelstein Kenneth J. (Lawrence KS) Higuchi Takeru (Lawrence KS), Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances d.
    상세보기
  2. Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable system for regenerating the periodontium.
    상세보기
  3. Baker Richard W. (Menlo Park CA), Controlled release drug delivery system for the periodontal pocket.
    상세보기
  4. Eppstein Deborah A. (Palo Alto CA) Schryver Brian B. (Redwood City CA), Controlled release of macromolecular polypeptides.
    상세보기
  5. Schmitt Edward Emil (Palo Alto CA) Polistina Rocco Albert (Port Chester NY), Controlled release of medicaments using polymers from glycolic acid.
    상세보기
  6. Sparks Randall T. (Gainesville GA) Geoghegan Edward J. (Athlone IEX), Controlled release powder and process for its preparation.
    상세보기
  7. Schmitt Edward E. (Palo Alto CA), Drug delivery devices comprising erodible polymer and erosion rate modifier.
    상세보기
  8. Choi ; Nam Sok ; Heller ; Jorge, Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates).
    상세보기
  9. Speaker Tully J. (Philadelphia PA) Chang Frank N. (Dresher PA) Hsu Stephen C. (Ambler PA), Encapsulated topical delivery system.
    상세보기
  10. Choi Nam S. (Seoul CA KRX) Heller Jorge (Palo Alto CA), Erodible agent releasing device comprising poly(orthoesters) and poly(orthocarbonates).
    상세보기
  11. Capozza Richard C. (Paradise Valley AZ), Erodible device comprising surfactant for modifying the rate of erosion of the device.
    상세보기
  12. Calanchi Massimo (05021986 Monza ITX) EPX European Pat. Off. (05021986 8600280 ITX) Gentilini Leonardo (Milano ITX) Marconi Marco (Cinisello Balsamo ITX), Formulation for preparing extemporaneous homogeneous microcapsule suspension.
    상세보기
  13. Parel Jean-Marie (Miami FL) Parrish Richard (Miami FL) Portugal Lourdes (Miami FL) Olsen Karl R. (Miami FL), Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agen.
    상세보기
  14. Shinoda Hosei (Aichi) Ohtaguro Masami (Nagoya) Iimuro Shigeru (Nagoya JPX), Modified polyester composition and preparation process and use thereof.
    상세보기
  15. Choi Nam S. (Seoul CA KRX) Heller Jorge (Palo Alto CA), Novel orthoester polymers and orthocarbonate polymers.
    상세보기
  16. Baker Richard W. (Palo Alto CA), Periodontal disease treatment system.
    상세보기
  17. Schmitt Edward E. (Palo Alto CA), Pharmaceutical composition of poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having.
    상세보기
  18. Schmitt ; Edward Emil, Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality.
    상세보기
  19. Choi ; Nam S. ; Heller ; Jorge, Structured orthoester and orthocarbonate drug delivery devices.
    상세보기
  20. Schmitt ; Edward Emil, Topical therapeutic preparations.
    상세보기

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  3. Alessi, Thomas R.; Leung, Karling Alice; Mercer, Ryan D.; Negulescu, Cristina G.; Rohloff, Catherine M.; Yang, Bing, Devices, formulations, and methods for delivery of multiple beneficial agents.
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  4. Shanley, John F., Expandable medical device for delivery of beneficial agent.
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  5. Johnston, Keith P.; Engstrom, Joshua; Williams, III, Robert O., Formation of stable submicron peptide or protein particles by thin film freezing.
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  6. Johnston, Keith P.; Engstrom, Joshua; Williams, III, Robert O., Formation of stable submicron peptide or protein particles by thin film freezing.
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  7. Smith, Jay S.; Cole, Michael R.; Whitson, Amy K., Implant placement guide.
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  8. Smith, Jay S.; Cole, Michael R.; Whitson, Amy K., Implant placement guide.
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  9. Shanley, John F.; Parker, Theodore L.; Park, Kinam, Implantable medical device with beneficial agent concentration gradient.
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  10. Chen, Guohua; Houston, Paul R.; Kleiner, Lothar Walter; Spaltro, John J., Injectable depot compositions and uses thereof.
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  11. Chen, Guohua; Houston, Paul; Kleiner, Lothar; Wright, Jeremy, Injectable multimodal polymer depot compositions and uses thereof.
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  12. Johnston, Keith P.; Mazuski, Maria Andrea; Engstrom, Joshua; Rodrigues, Miguel Angelo, Low viscosity highly concentrated suspensions.
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  13. Reinprecht, Jon T.; Gleiman, Seth; Elachchabi, Amin; Witherell, Ryan; Stopek, Joshua; Ebersole, Garrett, Medical device films.
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  14. Staas, Jay K.; Tice, Thomas R.; Hudson, Bruce W.; Tipton, Arthur J., Methods for manufacturing delivery devices and devices thereof.
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  15. Eliaz, Rom Ezer; Zhang, Yuanpeng; Rohloff, Catherine Manya; Weeks, Eric William; Junnarkar, Gunjan, Methods of manufacturing viscous liquid pharmaceutical formulations.
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  16. Alessi, Thomas R.; Mercer, Ryan D.; Rohloff, Catherine M.; Yang, Bing, Osmotic delivery device comprising an insulinotropic peptide and uses thereof.
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  17. Biggs, Danielle; Nettles, Heather, Process for preparing microparticles having a low residual solvent volume.
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  18. Alessi, Thomas R.; Luskey, Kenneth, Rapid establishment and/or termination of substantial steady-state drug delivery.
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  19. Chen, Guohua; Priebe, David, Short duration depot formulations.
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  20. Chen, Guohua; Priebe, David T., Short duration depot formulations.
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  21. Rohloff, Catherine M.; Chen, Guohua; Luk, Andrew S.; Ayer, Rupal A.; Houston, Paul R.; Desjardin, Michael A.; Zamora, Pauline; Lam, Stan, Solvent/polymer solutions as suspension vehicles.
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  22. Berry, Stephen A.; Fereira, Pamela J.; Dehnad, Houdin; Muchnik, Anna, Stable non- aqueous single phase viscous vehicles and formulations utilizing such vehicles.
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  23. Berry, Stephen A.; Fereira, Pamela J.; Dehnad, Houdin; Muchnik, Anna, Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles.
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  24. Berry, Stephen A.; Fereira, Pamela J.; Dehnad, Houdin; Muchnik, Anna, Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles.
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  25. Berry, Stephen A.; Fereira, Pamela J.; Dehnad, Houdin; Muchnik, Anna, Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles.
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  26. Berry, Stephen A.; Fereira, Pamela J.; Dehnad, Houdin; Muchnik, Anna, Stable non-aqueous single phase viscous vehicles and formulations utlizing such vehicles.
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  27. Shanley, John F.; Parker, Theodore L., Therapeutic agent delivery device with controlled therapeutic agent release rates.
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  28. Alessi, Thomas R.; Baron, Michelle, Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c.
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  29. Lautenbach, Scott C.; De La Serna, Pedro E.; Zamora, Pauline C.; Desjardin, Michael A., Two-piece, internal-channel osmotic delivery system flow modulator.
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