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[미국특허] Controlled release drug suspension delivery device 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/24
  • A61K-009/32
  • A61K-009/36
출원번호 US-0363451 (1994-12-22)
발명자 / 주소
  • Rork Gerald S. (Lawrence KS) Pipkin James D. (Lawrence KS)
출원인 / 주소
  • Merck & Co., Inc. (Rahway NJ 02)
인용정보 피인용 횟수 : 56  인용 특허 : 0

초록

A device is disclosed for the controlled delivery of a beneficial agent, the device consisting of (i) a core comprising at least two layers, wherein at least one layer comprises a beneficial agent and a polymer which forms microscopic gel beads upon hydration and at least one layer which comprises a

대표청구항

A drug delivery device for the controlled in situ production and release of a suspension containing a beneficial agent, consisting of: (a) a compressed core which comprises at least two layers, wherein at least one layer comprises an admixture of a therapeutically effective amount for those in need

이 특허를 인용한 특허 (56) 인용/피인용 타임라인 분석

  1. Kloke, Tim M.; Keough, Steven J.; Lockwood, Nathan; Gardner, Margaret R.; Hergenrother, Robert W.; Chappa, Ralph A., Beaded wound spacer device.
  2. Kim Cherng-ju, Coated tablet with long term parabolic and zero-order release kinetics.
  3. Kloke, Tim M.; Keough, Steven J.; Lockwood, Nathan; Gardner, Margaret R.; Hergenrother, Robert W.; Chappa, Ralph A., Coating composition.
  4. Sharma, Vinay K.; Hussain, Javed; Khorakiwala, Habil F., Composition for pulsatile delivery of diltiazem and process of manufacture.
  5. Sanders,Steven W.; Ebert,Charles D., Compositions and methods for minimizing adverse drug experiences associated with oxybutynin therapy.
  6. Sanders,Steven W.; Ebert,Charles D., Compositions and methods for minimizing adverse drug experiences associated with oxybutynin therapy.
  7. Sanders,Steven W.; Ebert,Charles D., Compositions and methods for minimizing adverse drug experiences associated with oxybutynin therapy.
  8. Sanders,Steven W.; Ebert,Charles D., Compositions and methods for minimizing adverse drug experiences associated with oxybutynin therapy.
  9. Ebert,Charles D.; Sanders,Steven W., Compositions and methods for transdermal oxybutynin therapy.
  10. Ebert,Charles D.; Sanders,Steven W., Compositions and methods for transdermal oxybutynin therapy.
  11. Kidane, Argaw, Compositions of quaternary ammonium compounds containing bioavailability enhancers.
  12. Cheng, Xiu Xiu; Qi, Xiaohong; Zhang, Guohua; Dixit, Manesh, Diltiazem controlled release formulation and method of manufacture.
  13. Lerner, E. Itzhak; Rosenberger, Vered; Aqua, Ofer; Fleshner Barak, Moshe, Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it.
  14. Chen Chih-Ming ; Chou Joseph ; Wong David, HMG co-reductase inhibitor.
  15. Chen, Chih-Ming; Chou, Joseph; Wong, David, HMG-CoA reductase inhibitor extended release formulation.
  16. MacGregor, Alexander, Hydrostatic delivery system for controlled delivery of agent.
  17. MacGregor,Alexander, Hydrostatic delivery system for controlled delivery of agent.
  18. Rodstrom, Theron Robert, Implantable drug delivery system.
  19. Moskowitz, Michael A.; Liao, James K.; Ron, Eyal S.; Omstead, Mary Nallin, Increasing cerebral bioavailability of drugs.
  20. Kidane, Argaw; Flanner, Henry H.; Bhatt, Padmanabh; Raoufinia, Arash, Method of treating bladder dysfunction with once-a-day trospium salt formulation.
  21. Geerke, Johan H.; Stone, Steven F., Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms.
  22. Geerke, Johan H; Stone, Steven F., Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms.
  23. Stone, Steven F.; Geerke, Johan H., Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms.
  24. Venkatesh, Gopi M.; Clevenger, James M., Modified release dosage forms of skeletal muscle relaxants.
  25. Venkatesh, Gopi M.; Clevenger, James M., Modified release dosage forms of skeletal muscle relaxants.
  26. Venkatesh, Gopi; Clevenger, James M., Modified release dosage forms of skeletal muscle relaxants.
  27. Venkatesh, Gopi; Clevenger, James M., Modified release dosage forms of skeletal muscle relaxants.
  28. Venkatesh, Gopi; Clevenger, James M., Modified release dosage forms of skeletal muscle relaxants.
  29. Venkatesh, Gopi; Clevenger, James M., Modified release dosage forms of skeletal muscle relaxants.
  30. Venkatesh, Gopi; Clevenger, James M., Modified release dosage forms of skeletal muscle relaxants.
  31. Venkatesh,Gopi; Clevenger,James M., Modified release dosage forms of skeletal muscle relaxants.
  32. Patrice Debregeas FR; Gerard Leduc FR; Pascal Oury FR; Pascal Suplie FR, Morphine sulfate microgranules, manufacturing process and pharmaceutical preparations.
  33. Chen Chih-Ming ; Chou Joseph C.H., Once daily calcium channel blocker tablet having a delayed release core.
  34. Kidane, Argaw; Flanner, Henry H.; Bhatt, Padmanabh; Raoufinia, Arash, Once daily dosage forms of trospium.
  35. Kidane, Argaw; Flanner, Henry H.; Bhatt, Padmanabh; Raoufinia, Arash, Once daily dosage forms of trospium.
  36. Chen Chih-Ming ; Chou Joseph C. H., Once daily pharmaceutical tablet having a unitary core.
  37. Chih-Ming Chen ; Joseph C. H. Chou, Once daily pharmaceutical tablet having a unitary core.
  38. Nogami, Eiji, Orally administered agent and an orally administered agent/supporting substrate complex.
  39. Shivanand Padmaja ; Hatamkhany Zahedeh ; Laidlaw Barbara F. ; Ayer Atul D., Phenytoin therapy.
  40. Sharma Vinay K., Process for the pulsatile delivery of diltiazem HCL and product produced thereby.
  41. Gelotte,Cathy Klech; Hills,Joanna F.; Pendley, II,Charles E.; Shah,Manoj N., Rapidly absorbed liquid compositions.
  42. Rinker, Roger A.; Casale, Nicholas J.; Comly, James H.; Pollock, Brenda; Ayer, Atul; Geerke, Johan; Costello, Martin; Wieand, Dennis; Parekh, Kishor, Rapidly disintegrating gelatinous coated tablets.
  43. Rinker, Roger A.; Casale, Nicholas J.; Comly, James H.; Pollock, Brenda; Ayer, Atul; Geerke, Johan; Costello, Martin; Wieand, Dennis; Parekh, Kishor, Rapidly disintegrating gelatinous coated tablets.
  44. Rinker, Roger A.; Casale, Nicholas J.; Comly, James H.; Pollock, Brenda; Ayer, Atul; Geerke, Johan; Costello, Martin; Wieand, Dennis; Parekh, Kishor, Rapidly disintegrating gelatinous coated tablets.
  45. Rinker, Roger A; Casale, Nicholas J.; Comly, James H.; Pollack, Brenda; Geerke, Johan; Costello, Martin; Wieand, Dennis; Parekh, Kishor, Rapidly disintegrating gelatinous coated tablets.
  46. Rinker, Roger A; Casale, Nicholas J.; Comly, James H.; Pollock, Brenda; Geerke, Johan; Costello, Martin; Wieand, Dennis; Parekh, Kishor, Rapidly disintegrating gelatinous coated tablets.
  47. Fox, Michael; Dorossiev, Ivo, Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids.
  48. Fox, Michael; Dorossiev, Ivo, Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids.
  49. Fox,Michael; Dorossiev,Ivo, Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids.
  50. Woo, Jong Soo; Yi, Hong-Gi; Chi, Moon-Hyuk; Ryu, Jae-Kuk; Jung, Si-Young; Kim, Yong-Il, Sustained release formulation for oral administration of HMG-CoA reductase inhibitor and method for the preparation thereof.
  51. Wells,David S.; Rajewski,Lian G.; Marriott,Thomas B.; Pipkin,James D.; Haslam,John L., Sustained-release formulations for treating CNS-mediated disorders.
  52. Kidane, Argaw; Flanner, Henry H.; Bhatt, Padmanabh; Raoufinia, Arash, Trospium chloride treatment method.
  53. Ebert, Charles D.; Sanders, Steven W., Unoccluded topical oxybutynin gel composition and methods for transdermal oxybutynin therapy.
  54. Fuller, Shawn; Claseman, Bryan A.; Slager, Joram; Missling, Jeffrey J.; Maharaj, Gary; Opperman, Gary W.; Lockwood, Nathan A.; Hergenrother, Robert W.; Olson, Charles, Wound packing device and method.
  55. Fuller, Shawn; Claseman, Bryan A.; Slager, Joram; Missling, Jeffrey J.; Maharaj, Gary; Opperman, Gary W.; Lockwood, Nathan; Hergenrother, Robert W.; Olson, Charles, Wound packing device and methods.
  56. Maharaj, Gary; Woodwick Sides, Teryl L., Wound packing device with nanotextured surface.

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