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Localized oligonucleotide therapy 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-048/00
출원번호 US-0369282 (1995-01-06)
발명자 / 주소
  • Rosenberg Robert D. (Jamestown RI) Simons Michael (Chestnut Hill MA) Edelman Elazer (Brookline MA) Langer Robert S. (Newton MA) DeKeyser Jean-Luc (Brussels BEX)
출원인 / 주소
  • Massachusetts Institute of Technology (Cambridge MA 02)
인용정보 피인용 횟수 : 75  인용 특허 : 4

초록 ▼

Disclosed is a method for localized application of antisense oligonucleotides, which has been found to be effective in inhibiting expression and translation of a variety of genes. The method utilizes antisense oligonucleotides which are specific for the mRNA transcribed from the gene of interest. Th

대표청구항 ▼

A method of inhibiting translation of a target nucleic acid sequence preferentially at a vascular tissue locus in vivo to thereby inhibit restenosis at said locus, the method comprising: directly applying to said vascular tissue locus within the body of a mammal an antisense oligonucleotide, compris

이 특허에 인용된 특허 (4)

  1. Gewirtz Alan M. (Philadelphia PA) Calabretta Bruno (Philadelphia PA), Antisence oligonucleotides to c-myb proto-oncogene and uses thereof.
    상세보기
  2. Fernandez Leonardo A. (Guilford CT), Inhibiting of tumor growth with an antagonist of the renin-angioten-sin system.
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  3. Goodchild John (Worcester MA) Zamecnik Paul C. (Shrewsbury MA), Inhibition of HTLV-III by exogenous oligonucleotides.
    상세보기
  4. March Keith L. (Carmel IN) Hathaway David R. (Indianapolis IN) Wilensky Robert L. (Indianapolis IN), Method for delivery of smooth muscle cell inhibitors.
    상세보기

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  1. Zalewski Andrew ; Shi Yi, Antisense inhibition of c-myc to modulate the proliferation of smooth muscle cells.
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  2. Dean Nicholas M. ; McKay Robert ; Miraglia Loren ; Baker Brenda, Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos.
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  3. McKay Robert ; Dean Nicholas ; Monia Brett P. ; Nero Pamela S. ; Gaarde William A., Antisense oligonucleotide compositions and methods for the modulation of JNK proteins.
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  4. McKay Robert ; Dean Nicholas ; Monia Brett P. ; Nero Pamela Scott ; Gaarde William A., Antisense oligonucleotide compositions and methods for the modulation of JNK proteins.
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  5. Dean Nicholas M. ; McKay Robert ; Miraglia Loren ; Baker Brenda, Antisense oligonucleotide compositions and methods for the modulation of activating protein 1.
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  6. Iyer, Sriram S.; Kipshidze, Nicholas N.; Nikolaychik, Victor V., Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts.
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  7. Iyer, Sriram S.; Kipshidze, Nicholas N.; Nikolaychik, Victor V., Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts.
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  8. Iyer, Sriram S.; Kipshidze, Nicholas N.; Nikolaychik, Victor V., Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts.
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  9. Zalewski Andrew ; Shi Yi, Arteriovenous and venous graft treatments: methods and compositions.
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  19. Vacanti Charles A. ; Vacanti Joseph P., Guided development and support of hydrogel-cell compositions.
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  20. Vacanti Charles A. ; Vacanti Joseph P. ; Vacanti Martin P., Guided development and support of hydrogel-cell compositions.
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  21. Goldstein Steven A. ; Bonadio Jeffrey, In vivo gene transfer methods for wound healing.
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  22. van Ommen, Garrit-Jan B.; van Deutekom, Judith C. T.; den Dunnen, Johannes T., Induction of exon skipping in eukaryotic cells.
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  23. Zalewski Andrew ; Shi Yi, Inhibition of extracellular matrix synthesis by antisense compounds directed to nuclear proto-oncogenes.
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  24. Dzau Victor J., Inhibition of proliferation of vascular smooth muscle cell.
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  25. Dzau Victor J., Inhibition of proliferation of vascular smooth muscle cell.
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  26. Vacanti,Charles A.; Vacanti,Martin P., Isolation of spore-like cells from tissues exposed to extreme conditions.
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  27. Hardee Gregory E. ; Geary Richard S. ; Levin Arthur ; Templin Michael V. ; Howard Randy ; Mehta Rahul C., Liposomal oligonucleotide compositions for modulating RAS gene expression.
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  28. Aartsma-Rus, Annemieke; Van Deutekom, Judith Christina T.; Van Ommen, Garrit-Jan Boudewijn, Means and method for inducing exon-skipping.
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  29. De Kimpe, Josephus Johannes; Platenburg, Gerard Johannes; Van Deutekom, Judith Christina Theodora; Aartsma-Rus, Annemieke; Van Ommen, Garrit-Jan Boudewijn, Means and methods for counteracting muscle disorders.
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  32. Fradet, Yves; Chypre, Camille; Piche, Lyson; Garon, Genevieve, Method to detect prostate cancer in a sample.
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  35. van Deutekom, Judith Christina Theodora, Methods and means for efficient skipping of at least one of the exons 51-53, 55, 57 and 59 of the human duchenne muscular dystrophy gene.
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  36. De Kimpe, Josephus Johannes; Platenburg, Gerardus Johannes; Van Deutekom, Judith Christina Theodora; Aartsma-Rus, Annemieke; Van Ommen, Garrit-Jan Boudewijn, Methods and means for efficient skipping of exon 45 in Duchenne muscular dystrophy pre-mRNA.
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  37. De Kimpe, Josephus Johannes; Rus, Adriana Marie; Platenburg, Gerard Johannes; Van Deutekom, Judith Christina Theodora; Van Ommen, Garrit-Jan Boudewijn, Methods and means for efficient skipping of exon 45 in duchenne muscular dystrophy pre-mRNA.
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  42. Kohn Harold L. ; Huh Nam ; Kogan Timothy P. ; Rege Ajay A., Mitomycin oligonucleotide conjugates.
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  47. van Ommen, Garrit-Jan Boudewijn; van Deutekom, Judith Christina Theodora; den Dunnen, Johannes Theodorus; Aartsma-Rus, Annemieke, Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure.
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  51. Stein,Cy A.; Cossum,Paul; Rando,Robert; Ojwang,Joshua, Oligonucleotide inhibitors of bcl-xL.
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  53. Busse, Ursula; Chypre, Camille; Fradet, Yves, PCA3 messenger RNA species in benign and malignant prostate tissues.
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  63. de Visser, Peter Christian; van Deutekom, Judith Christina Theodora, RNA modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy.
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  64. Vacanti, Martin P.; Vacanti, Charles A., Spore-like cells and uses thereof.
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  67. Vacanti, Martin P.; Vacanti, Charles A., Subpopulations of spore-like cells and uses thereof.
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  70. 't Hoen, Peter Abraham Christiaan; Sterrenburg, Petronella Johanna Elisabeth; den Dunnen, Johannes Theodorus; van Ommen, Garrit Jan Boudewijn, Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly or abnormally expressed gene.
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  71. Michal Eugene T. ; Buchko Christopher J. ; Bigus Stephen J., Therapeutic, diagnostic, or hydrophilic coating for an intracorporeal medical device.
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  72. Vacanti Charles A., Tissue re-surfacing with hydrogel-cell compositions.
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