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Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointes 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-009/02
  • A61K-009/68
  • A01N-037/12
  • A01N-037/18
출원번호 US-0422350 (1995-04-14)
발명자 / 주소
  • Hechtman Herbert B. (Chestnut Hill MA)
출원인 / 주소
  • President and Fellows of Harvard College (Cambridge MA 02)
인용정보 피인용 횟수 : 33  인용 특허 : 4

초록

A topical treatment for hemorrhoidal pain and for spasms of the sphincters and muscles located in the gastrointestinal (GI) tract is disclosed. The topical preparation includes the amino acid L-arginine in a pharmaceutically acceptable carrier substance, e.g., K-Y jelly, suppository, or ingestible f

대표청구항

A method of treating hemorrhoidal pain or other medical condition arising from a spasm in the smooth muscle of the gastrointestinal tract of a patient, said method comprising: applying a topical preparation of L-arginine in an pharmaceutically acceptable carrier to an area of the gastrointestinal tr

이 특허에 인용된 특허 (4)

  1. Veech Richard L. (712 Brent Rd. Rockville MD 20850), Electrolyte solutions and in vitro use thereof.
  2. Cooke John P. (Palo Alto CA) Dzau Victor J. (Los Altos Hills CA) Gibbons Gary H. (Palo Alto CA), Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity.
  3. Levere Richard D. (5 Seymour Pl. W. Armonk NY 10504) Abraham Nader G. (143 Charter Cir. Ossining NY 10562) Schwartzman Michel L. (415 Old Country Rd. Elmsford NY 10523) Martasek Pavel (60 Hillcrest R, Use of L-arginine in the treatment of hypertension and other vascular disorders.
  4. Sakaguchi Minoru (Tondabayashi JPX) Awata Norio (Yamatokoriyama JPX) Kawashima Tsuneo (Osaka JPX) Nakagawa Hiroshi (Nagaokakyo JPX), Vaginal suppository.

이 특허를 인용한 특허 (33)

  1. Whitlock, David R.; Jamas, Spiros; Weiss, Larry, Ammonia oxidizing bacteria for treatment of acne.
  2. Whitlock, David R.; Jamas, Spiros; Weiss, Larry, Ammonia oxidizing bacteria for treatment of eczema.
  3. Whitlock, David R., Articles of clothing treated with ammonia oxidizing bacteria to produce nitric oxide.
  4. Fossel, Eric T., Beneficial effects of increasing local blood flow.
  5. Lemko, Mark; Patel, Pravin M., Composition and method for the treatment of anorectal disorders.
  6. Parks, Thomas P.; Mak, Vivien; Lee, Jung-Chung; Lee, Charles, Compositions and methods for the treatment of anorectal disorders.
  7. Sacks,Meir S.; Van Dyke,Knox, Compositions and methods for treating sexual dysfunction.
  8. Whitlock, David R., Compositions including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same.
  9. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  10. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  11. Fossel, Eric T., Delivery of ibuprofen and other compounds.
  12. Wilks, Angela; MacKerrel, Jr., Alexander; Furci, Lena; Lopes, Pedro, Heme oxygenase inhibitors, screening methods for heme oxygenase inhibitors and methods of use of heme oxygenase inhibitors for antimicrobial therapy.
  13. Fogel Barry S., Method for treating painful conditions of the anal region and compositions therefor.
  14. Gorfine,Stephen R., Nitric oxide donor composition and method for treatment of anal disorders.
  15. Kamm, Michael A.; Phillips, Robin K.S., Pharmaceutical composition for treating fecal incontinence and anal itch.
  16. Fossel, Eric T., Systems and methods for treatment of allergies and other indications.
  17. Eric T. Fossel, Topical and oral delivery of arginine to cause beneficial effects.
  18. Fossel Eric T., Topical and oral delivery of arginine to cause beneficial effects.
  19. Fossel, Eric T., Topical composition containing ibuprofen.
  20. Fossel, Eric T., Topical composition containing naproxen.
  21. Barone, Jr.,Frank V.; Jacobsen,Christopher; Chumenko,Kirill, Topical compositions for enhancing sexual responsiveness.
  22. Fossel, Eric T., Topical delivery of L-arginine to cause beneficial effects.
  23. Fossel, Eric T., Topical delivery of L-arginine to cause beneficial effects.
  24. Fossel Eric T., Topical delivery of L-arginine to cause tissue warming.
  25. Fossel Eric T., Topical delivery of arginine to overcome pain.
  26. Fossel, Eric Thor, Transdermal delivery of beneficial substances effected by a hostile biophysical environment.
  27. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  28. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  29. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  30. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  31. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  32. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
  33. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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