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Piezoelectric device for detection of polynucleotide hybridization 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12M-001/34
  • G21D-007/02
  • H02K-041/00
  • C12N-015/00
출원번호 US-0392734 (1989-08-11)
발명자 / 주소
  • Fawcett Newton C. (Hattiesburg MS) Evans Jeffrey A. (Hattiesburg MS)
출원인 / 주소
  • University of Southern Mississipi (Hattiesburg MS 02)
인용정보 피인용 횟수 : 79  인용 특허 : 7

초록 ▼

A system for detecting polynucleotide hybridization is disclosed. A polynucleotide is immobilized on a surface of a piezoelectric crystal. The resonance frequency of the piezoelectric crystal is measured through means for determining the resonant frequency of a piezoelectric crystal. A separate sour

대표청구항

A device for detecting polynucleotide hybridization comprising: (a) a piezoelectric crystal; (b) a polynucleotide attached to a surface of said crystal by a linker; and (c) a means for determining the resonance frequency of said crystal.

이 특허에 인용된 특허 (7)

  1. Ranki Tuula M. (Espoo FIX) Soderlund Hans E. (Espoo FIX), Detection of microbial nucleic acids by a one-step sandwich hybridization test.
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  2. Hafeman Dean (San Bruno CA) Parce John W. (Winston-Salem NC) McConnell Harden M. (Stanford CA), Device having photoresponsive electrode for determining analytes including ligands and antibodies.
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  3. Oliveira Robert J. (Maplewood MN) Silver Spencer F. (White Bear Lake MN), Immunoassay for antigens.
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  4. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
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  5. Rice Thomas K. (White Bear Lake MN), Method for the assay of classes of antigen-specific antibodies.
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  6. Paul David W. (Fayetteville AR) Beeler Theodore L. (Fayetteville AR), Piezoelectric sensor Q-loss compensation.
    상세보기
  7. Rice Thomas K. (White Bear Lake MN), Sandwich immunoassay using piezoelectric oscillator.
    상세보기

이 특허를 인용한 특허 (79)

  1. Kayyem,Jon Faiz; O'Connor,Stephen D., AC/DC voltage apparatus for detection of nucleic acids.
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  2. Blackburn, Gary; Irvine, Bruce D.; Kayyem, Jon Faiz; Sheldon, III, Edward Lewis; Terbrueggen, Robert H., Amplification of nucleic acids with electronic detection.
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  3. Kayyem,Jon Faiz; Bamdad,Cynthia, Amplification of nucleic acids with electronic detection.
    상세보기
  4. Majumdar,Arunaya; Perazzo,Thomas Michael; Mao,Minyao; Kwon,Ohmyoung; Zhao,Yang; Wu,Guanghua, Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks.
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  5. Centanni, Michael A., Apparatus for controlling the concentration of a sterilant chemical in a fluid.
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  6. Centanni, Michael A., Apparatus for determining the efficiency of a vaporizer in a decontamination system.
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  7. Blackburn Gary ; Creager Stephen E. ; Fraser Scott ; Irvine Bruce D. ; Meade Thomas J. ; O'Connor Stephen D. ; Terbrueggen Robert H. ; Vielmetter Jost G. ; Welch Thomas W., Binding acceleration techniques for the detection of analytes.
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  8. Blackburn, Gary; Creager, Stephen E.; Fraser, Scott; Irvine, Bruce D.; Meade, Thomas J.; O'Connor, Stephen J.; Terbrueggen, Robert H.; Vielmetter, Jost G.; Welch, Thomas W., Binding acceleration techniques for the detection of analytes.
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  10. Shieh, Chan-Long; Foley, Barbara; Yu, Huinan; Choong, Vi-En, Biochannel assay for hybridization with biomaterial.
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  11. Zhang, Yuegang; Berlin, Andrew A.; Ma, Qing; Wang, Li-Peng; Rao, Valluri; Yamakawa, Mineo, Biosensor utilizing a resonator having a functionalized surface.
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  15. Albert, Fred; Wright, Brad, Bridged element for detection of a target substance.
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  16. Britton ; Jr. Charles L. ; Warmack Robert J. ; Bryan William L. ; Jones Robert L. ; Oden Patrick Ian ; Thundat Thomas, Capacitively readout multi-element sensor array with common-mode cancellation.
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  17. Norris, Michael C.; Lobban, Peter; Besemer, Donald; Carlson, Andrew B., Cartridge loader and methods.
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  18. Norris, Michael C.; Lobban, Peter; Besemer, Donald; Carlson, Andrew B., Cartridge loader and methods.
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  19. Norris,Michael C.; Lobban,Peter; Besemer,Donald; Carlson,Andrew B., Cartridge loader and methods.
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  20. Certa, Ulrich; Tschirky, Hansjorg, Cartridge washing system and methods.
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  21. Ulrich Certa CH; Hansjorg Tschirky CH, Cartridge washing system and methods.
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  22. Kayyem,Jon Faiz; O'Connor,Stephen D., Compositions for the electronic detection of analytes utilizing monolayers.
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  23. Kayyem,Jon Faiz; O'Connor,Stephen D., Compositions for the electronic detection of analytes utilizing monolayers.
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  24. Kayyem,Jon Faiz; O'Connor,Stephen D.; Gozin,Michael; Yu,Changjun; Meade,Thomas J., Conductive oligomers attached to electrodes and nucleoside analogs.
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  25. Meade Thomas J., Detection of analytes using reorganization energy.
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  26. Meade Thomas J., Detection of analytes using reorganization energy.
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  27. Meade Thomas J., Detection of analytes using reorganization energy.
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  28. Meade,Thomas J., Detection of analytes using reorganization energy.
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  29. Meade,Thomas J., Detection of analytes using reorganization energy.
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  30. Bamdad, Cynthia C.; Mucic, Robert C., Detection of target analytes using particles and electrodes.
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  31. Bamdad, Cynthia C.; Mucic, Robert C., Detection of target analytes using particles and electrodes.
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  32. Bamdad, Cynthia C.; Mucic, Robert C., Detection of target analytes using particles and electrodes.
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  33. Willner, Itamar; Levi, Shlomo; Cohen, Yael; Katz, Eugenii; Dagan, Arie, Determination of an analyte in a liquid medium.
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  34. Blackburn,Gary; Duong,Hau H.; Grodzinski,Piotr; Kayyem,Jon Faiz; O'Connor,Stephen D.; Pietri,Robert; Terbrueggen,Robert Henry; Zenhausern,Frederic; Olsen,Gary T., Devices and methods for biochip multiplexing.
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  35. Duong,Hau H.; Blackburn,Gary; Kayyem,Jon F.; O'Connor,Stephen D.; Olsen,Gary T.; Pietri,Robert; Terbrueggen,Robert H., Devices and methods for biochip multiplexing.
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  36. Jon F. Kayyem ; Stephen D. O'Connor ; Michael Gozin ; Changjun Yu, Electrodes linked via conductive oligomers to nucleic acids.
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  37. Kayyem,Jon Faiz; O'Connor,Stephen D.; Gozin,Michael; Yu,Changjun, Electrodes linked via conductive oligomers to nucleic acids.
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  38. Thundat Thomas G. ; Warmack Robert J. ; Wachter Eric A., Electromagnetic and nuclear radiation detector using micromechanical sensors.
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  39. Kayyem,Jon F.; O'Connor,Stephen D.; Gozin,Michael; Yu,Changjun; Meade,Thomas J., Electronic transfer moieties attached to peptide nucleic acids.
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  40. Donald Besemer ; Peter E. Lobban ; Michael C. Norris ; Steven V. Muller, Fluidics station injection needles with distal end and side ports and method of using.
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  41. Besemer Donald ; Lobban Peter E. ; Norris Michael C. ; Muller Steven V., Fluidics station with a mounting system and method of using.
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  42. Johal, Gaganbir Singh; Harmon, Ian Robert; Van Deusen, Richard Allen, Measurement of binding kinetics with a resonating sensor.
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  43. Meade Thomas J. ; Kayyem Jon F., Metallic solid supports modified with nucleic acids.
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  44. Meade,Thomas J.; Kayyem,Jon F., Metallic solid supports modified with nucleic acids.
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  45. Michael L. Buess ; Allen N. Garroway ; Joel B. Miller ; James P. Yesinowski ; Roy P. Lindquist, Method and apparatus for detecting a target material in a sample by pre-screening the sample for piezoelectric resonance.
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  46. Centanni, Michael A., Method for determining the efficiency of a vaporizer in a decontamination system.
    상세보기
  47. Choong, Vi-En; Li, Changming; Shi, Song; Maracas, George, Method for enhanced bio-conjugation events.
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  48. Centanni,Michael A, Method of monitoring operational status of sensing devices for determining the concentration of chemical components in a fluid.
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  49. Stern, David; Fiekowsky, Peter, Methods and apparatus for detection of fluorescently labeled materials.
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  50. Stern, David; Gao, Chuan; Yamamoto, Melvin; Nguyen, Devin, Methods and devices for reading microarrays.
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  52. Kayyem Jon Faiz ; O'Connor Stephen D. ; Gozin Michael ; Yu Changjun ; Meade Thomas J., Methods of detecting nucleic acids using electrodes.
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  53. Blackburn, Gary, Microfluidic devices comprising biochannels.
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  54. Kayyem, Jon Faiz, Microfluidic systems in the electrochemical detection of target analytes.
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  55. Thundat Thomas G. ; Jacobson K. Bruce ; Doktycz Mitchel J. ; Kennel Stephen J. ; Warmack Robert J., Micromechanical antibody sensor.
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  56. Thundat Thomas G., Micromechanical potentiometric sensors.
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  57. Bamdad, Cynthia C.; Sigal, George B.; Strominger, Jack L.; Whitesides, George M., Molecular recognition at surfaces derivatized with self-assembled monolayers.
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  58. Liu,James Z T, Multiple function bulk acoustic wave liquid property sensor.
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  59. Meade Thomas J. ; Kayyem Jon Faiz ; Fraser Scott E., Nucleic acid mediated electron transfer.
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  65. Meade, Thomas J.; Kayyem, Jon Faiz; Fraser, Scott E., Nucleic acid mediated electron transfer.
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  66. Thomas J. Meade ; Thomas W. Welch, Nucleosides comprising polydentate ligands.
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  68. Mohammed, Mansoor S.; Dzidic, Natasa; McCaskill, Christopher, Rapid comparative genomic hybridization using acoustic surface waves.
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  71. Shirazi, Mohsen, System and method for processing large number of biological microarrays.
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  74. Weiner, Nathan K.; Odoy, Patrick J.; Schultz, Eric; Jones, Mark; Overbeck, James; Deweerd, Herman; Stura, David A.; Bukys, Albert; Woolaver, Tim; Regan, Thomas P.; Bradbury, David; McKenzie, Eric Earl; DiPaolo, Roger; Miles, Christopher; Katz, Joel M.; Oleink-Ovod, Ksenia, System, method, and product for scanning of biological materials.
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  75. Weiner, Nathan K.; Odoy, Patrick J.; Schultz, Eric; Jones, Mark; Overbeck, James; Deweerd, Herman; Stura, David A.; Bukys, Albert; Woolaver, Tim; Regan, Thomas P.; Bradbury, David; McKenzie, Eric Earl; DiPaolo, Roger; Miles, Christopher; Katz, Joel M.; Oleink-Ovod, Ksenia, System, method, and product for scanning of biological materials.
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  76. Weiner, Nathan K.; Odoy, Patrick J.; Schultz, Erik; Jones, Mark; Overbeck, James; Deweerd, Herman; Stura, David A.; Bukys, Albert; Woolaver, Tim; Regan, Thomas P.; Bradbury, David; McKenzie, Eric Earl; DiPaolo, Roger; Miles, Christopher; Katz, Joel; Oleink-Ovod, Ksenia, System, method, and product for scanning of biological materials.
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  77. Kaiser,Michael D., System, method, and product for scanning of biological materials employing dual analog integrators.
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  78. Kayyem Jon Faiz ; Blackburn Gary ; O'Connor Stephen D., Systems for electrophoretic transport and detection of analytes.
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  79. Kayyem, Jon Faiz, Tissue collection devices containing biosensors.
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