초록 ▼

The present invention provides a local drug delivery film, which is characterized by comprising, as release control component, polymer mixture consistiong of polycaprolactone having molecular weight of 30,000-60,000 and polycaprolactone having molecular weight less than 1,000 in a ratio of 1:1-4:1,

The present invention provides a local drug delivery film, which is characterized by comprising, as release control component, polymer mixture consistiong of polycaprolactone having molecular weight of 30,000-60,000 and polycaprolactone having molecular weight less than 1,000 in a ratio of 1:1-4:1, and as active component, periodontal therapeutic agent. The present local drug delivery film is prepared by admixing homogeneously active component with melted polymer mixture and pressing into film. And the present drug delivery film has excellent sustained release pattern and excellent treatment effect in oral disease with release amount 1.7 mg. which is 0.12% of prescription amount, 1400 mg. for adults during 7 days and provides the application stability into human body.

대표청구항 ▼

A local drug delivery film for periodontal treatment containing a release component and an active component consisting of, (a) as release component, 60% to 90% by total weight of drug delivery film of polymer mixture of polycaprolactone I having number average molecular weight in a range of from 30,

A local drug delivery film for periodontal treatment containing a release component and an active component consisting of, (a) as release component, 60% to 90% by total weight of drug delivery film of polymer mixture of polycaprolactone I having number average molecular weight in a range of from 30,000 to 60,000 and polycaprolactone II having number average molecular weight less than 1,000, the content ratio of the polycaprolactone I to polycaprolactone II being from 1:1 to 4:1, and (b) as active component, 10% to 40% by total weight of drug delivery film of periodontal therapeutic agent.