[특허]Transdermal drug applicator and electrodes therefor

Transdermal drug applicator and electrodes therefor 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61N-001/30
출원번호	US-0136726 (1993-10-14)
발명자 / 주소	Sibalis Dan (Stony Brook NY)
출원인 / 주소	Drug Delivery Systems Inc. (New York NY 02)
인용정보	피인용 횟수 : 63 인용 특허 : 0

초록 ▼

An improved transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream embodying at least two electrode elements forming the applicator and with the electrodes separated from each other by insulating means. A reservoir means, in at least one of said electrode elements of said applicator, containing said medicament; and a circuit, including a power source, for supplying electric power to said electrodes and such reservoir means. Suitable cover means partially enclosed at least said reservoir means, and adhesive means affixes the applicator to the skin, so as to complete an electrical circuit through the skin when the applicator is affixed thereto, thus creating at least one physico/chemical mass transfer phenomenon which causes said medicament to migrate through the skin.

대표청구항 ▼

An electrically powered transdermal drug applicator having at least one medicament for application to a living body for the migration of the at least one medicament through the skin into the blood stream comprising essentially of the following elements: Three generally flat electrode elements, free of a flexible, non-conductive substrate having conductive coated areas and free of any folds, and forming a transdermal drug applicator with multiple electrode elements, and with one electrode element thereof being separated from the other two which are juxtaposed to each other, and with two of said three electrode elements being either an active medicament containing electrode element or an inactive electrode element having no medicament, reservoir means having a predetermined depth and a plurality of sides forming a periphery, in each of said electrode elements of said transdermal drug applicator, with at least one of said juxtaposed electrode elements including said reservoir means containing said at least one medicament; and said reservoir means being free of transversing elements passing through at least a portion of said electrode elements and/or said reservoir means; each of said electrode elements, including said at least one having said at least one medicament in said reservoir means having an impermeable tacky, non-conducting and insulating barrier seal coextensive with the sides of said electrode elements and said reservoir means and extending along at least the full depth of said electrode elements and said reservoir means, so as to form an effective dam between said juxtaposed electrode elements and said reservoir means, with an end lip-like curtain about all sides forming said periphery of said electrode elements and said reservoir means; the dam-like barrier seal maintaining electrode and reservoir separation of said juxtaposed electrode and reservoir elements from each other and forming a tacky peripheral lip seal against the skin for precluding electrical shorting across said electrode-reservoir elements; an electrical circuit, including a power source and current control device, for supplying electrical power in parallel to all of said electrode elements and said reservoir means and forming a closed electrical loop circuit from said power source connected via conductors to said electrode elements and said reservoir means, and the skin when the transdermal drug applicator is applied thereto; a relatively, thin non-conductive cover means partially enclosing and conforming to said electrode elements and said reservoir means so as to envelope at least said electrode elements and said reservoir means and at least portions of said electrical circuit and leaving sides of said electrode elements and said reservoir means exposed for contact with the skin, and adhesive means for affixing said transdermal drug applicator to said skin, whereby said electrical circuit through the skin is formed when said transdermal drug applicator is adhesively affixed to said skin, thereby creating at least one physico/chemical mass transfer phenomenon which causes said at least one medicament to migrate from said reservoir means containing said at least one medicament through the skin and into the blood stream of said living body.

이 특허를 인용한 특허 (63)

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Beck, Jon E.; Hause, Jr., Robert F., Method and apparatus for electrotherapy drug delivery.
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Hause, Jr., Robert F.; Beck, Jon E., Method and apparatus for electrotherapy drug delivery.
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Zhang, Jie; Zhang, Hao, Method and apparatus for improved heat controlled administration of pharmaceuticals.
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Imran, Mir; Hashim, Mir; Patel, Sanjay; Berenson, Ronald J., Method for transdermal iontophoretic delivery of chelated agents.
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Anderson, Carter R.; Sembrowich, Walter L.; Morris, Russell L.; Cohen, Robert, Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Transdermal drug applicator and electrodes therefor 원문보기

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Transdermal drug applicator and electrodes therefor 원문보기

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