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A solvent debubbling/priming device for use in high pressure liquid chromatographic applications includes a valve adapted for releasable and sealed attachment to a bubble collecting/solvent reservoir. The valving portion of the device comprises a valve body with bores formed therein for controlled a

A solvent debubbling/priming device for use in high pressure liquid chromatographic applications includes a valve adapted for releasable and sealed attachment to a bubble collecting/solvent reservoir. The valving portion of the device comprises a valve body with bores formed therein for controlled access and communication between the bubble collecting/solvent reservoir and the exterior of the valve, or atmosphere. The solvent debubbling/priming means includes a length of flexible tubing which has a flattened portion at its distal end and with the tubing being in communication with the bubble collecting/solvent reservoir. The flexible tubing along with its flattened portion provides a flow control and check valve which is chemically inert and free of potentially contaminating lubricants for effective utilization.

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Solvent debubbling/priming means for use in high pressure liquid chromatographic applications and including valving means adapted for releasable and sealed attachment to a bubble collecting HPLC solvent reservoir, the valving means comprising a valve body with bores formed therein for controlled acc

Solvent debubbling/priming means for use in high pressure liquid chromatographic applications and including valving means adapted for releasable and sealed attachment to a bubble collecting HPLC solvent reservoir, the valving means comprising a valve body with bores formed therein for controlled access and communication between said bubble collecting/solvent reservoir and the exterior of said valve, said debubbling priming means being characterized in that: (a) said valve body consists essentially of an inner core and an outer sleeve arranged concentrically with said core; (b) said inner core and outer sleeve combination having a plurality of bores formed therein providing communication between said bubble collecting/solvent reservoir and the exterior of said valve and including a plurality of means disposed in cooperative relationship with said bores for controlling flow of fluids to and from said reservoir; (c) first of said fluid flow control means including a length of flexible tubing disposed within a first of said plurality of bores and with said tubing being in communication with said reservoir and with the outer diameter of said length of tubing being less than the inner diameter of said first bore, said tubing being further characterized in that: (1) said tubing consists of polytetrafluoroethylene having a diameter of between about 0.062 inches and 0.125 inches and with a wall thickness of between about 1 mils and 3 mils, and having the distal end thereof formed flat by pressure and/or heat to provide a check valve permitting fluid flow in one direction therethrough to a zone of substantially equal or lower pressures.