IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0951931
(1992-09-25)
|
|
발명자
/ 주소 |
- Cardinal John R. (Groton CT) Herbig Scott M. (Groton CT) Korsmeyer Richard W. (Groton CT) Lo Jeelin (Groton CT) Smith Kelly L. (Groton CT) Thombre Avinash G. (Groton CT)
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| 출원인 / 주소 |
- Pfizer Inc. (New York NY 02)
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| 인용정보 |
피인용 횟수 :
57 인용 특허 :
27 |
초록
A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping.
대표청구항
▼
A process for preparing a tablet for controlled release of one or more active substances into an environment, said tablet comprised of a core of said active substances, with or without one or more excipients, surrounded by an asymmetric membrane selected from the group consisting of mono-, di- and t
A process for preparing a tablet for controlled release of one or more active substances into an environment, said tablet comprised of a core of said active substances, with or without one or more excipients, surrounded by an asymmetric membrane selected from the group consisting of mono-, di- and triacyl cellulose esters wherein said acyl group contains from two to four carbon atoms, alkyl cellulose ethers wherein said alkyl group contains one to four carbon atoms, cellulose nitrate, acetaldehyde dimethyl cellulose, cellulose acetate ethyl carbamate, cellulose acetate phthalate, cellulose acetate methyl carbamate, cellulose acetate succinate, cellulose acetate dimethaminoacetate, cellulose acetate ethyl carbonate, cellulose acetate chloroacetate, cellulose acetate ethyl oxalate, cellulose acetate methyl sulfonate, cellulose acetate butyl sulfonate, cellulose acetate p-toluene sulfonate, cellulose cyanoacetates, cellulose acetate trimellitate, cellulose methacrylates, polysulfones, polyamides, polyurethanes, polypropylene, ethylene-vinyl acetate, polyvinyl chloride, polyvinyl alcohol, ethylenevinyl alcohol, polyvinylidene fluoride and polymethyl methacrylate comprising: coating said core with a solution of a material selected from the group consisting of mono-, di- and triacyl cellulose esters wherein said acyl group contains from two to four carbon atoms, alkyl cellulose ethers wherein said alkyl group contains one to four carbon atoms, cellulose nitrate, acetaldehyde dimethyl cellulose, cellulose acetate ethyl carbamate, cellulose acetate phthalate, cellulose acetate methyl carbamate, cellulose acetate succinate, cellulose acetate dimethaminoacetate, cellulose acetate ethyl carbonate, cellulose acetate chloroacetate, cellulose acetate ethyl oxalate, cellulose acetate methyl sulfonate, cellulose acetate butyl sulfonate, cellulose acetate p-toluene sulfonate, cellulose cyanoacetates, cellulose acetate trimellitate, cellulose methacrylates, polysulfones, polyamides, polyurethanes, polypropylene, ethylene-vinyl acetate, polyvinyl chloride, polyvinyl alcohol, ethylenevinyl alcohol, polyvinylidene fluoride and polymethyl methacrylate; and inducing a phase separation to occur. A process for preparing a capsule for controlled release of one or more active substances into an environment, said capsule comprised of a core of said active substances, with or without one or more excipients, surrounded by an asymmetric membrane selected from the group consisting of mono-, di- and triacyl cellulose esters wherein said acyl group contains two to four carbon atoms, alkyl cellulose ethers wherein said alkyl group contains one to four carbon atoms, cellulose acetate butyl sulfonate, cellulose acetate p-toluene sulfonate, cellulose cyanoacetates, cellulose acetate trimellitate, cellulose methacrylates, cellulose nitrate, acetaldehyde dimethyl cellulose, cellulose acetate ethyl carbamate, cellulose acetate phthalate, cellulose acetate methyl carbamate, cellulose acetate succinate, cellulose acetate dimethaminoacetate, cellulose acetate ethyl carbonate, cellulose acetate chloroacetate, cellulose acetate ethyl oxalate, cellulose acetate methyl sulfonate, polysulfones, polyamides, polyurethanes, polypropylene, ethylene-vinyl acetate, polyvinyl chloride, polyvinyl alcohol, ethylenevinyl alcohol, polyvinylidene fluoride and polymethyl methacrylate comprising: coating a mandrel with a solution of a material selected from the group consisting of mono-, di- and triacyl cellulose esters wherein said acyl group contains from two to four carbon atoms, alkyl cellulose ethers wherein said alkyl group contains one to four carbon atoms, cellulose nitrate, acetaldehyde dimethyl cellulose, cellulose acetate ethyl carbamate, cellulose acetate phthalate, cellulose acetate methyl carbamate, cellulose acetate succinate, cellulose acetate dimethaminoacetate, cellulose acetate ethyl carbonate, cellulose acetate chloroacetate, cellulose acetate ethyl oxalate, cellulose acetate methyl sulfonate, cellulose acetate butyl sulfonate, cellulose acetate p-toluene sulfonate, cellulose cyanoacetates, cellulose acetate trimellitate, cellulose methacrylates, polysulfones, polyamides, polyurethanes, polypropylene, ethylene-vinyl acetate, polyvinyl chloride, polyvinyl alcohol, ethylenevinyl alcohol, polyvinylidene fluoride and polymethyl methacrylate; inducing a phase separation to occur to form a capsule; and filling said capsule with said core. A process for preparing beads for controlled release of one or more active substances into an environment, said beads comprised of a core of said active substances, with or without one or more excipients, surrounded by an asymmetric membrane comprising: coating said core with a solution of a material selected from the group consisting of mono-, di- and triacyl cellulose esters wherein said acyl group contains from two to four carbon atoms, alkyl cellulose ethers wherein said alkyl group contains one to four carbon atoms, cellulose nitrate, acetaldehyde dimethyl cellulose, cellulose acetate ethyl carbamate, cellulose acetate phthalate, cellulose acetate methyl carbamate, cellulose acetate succinate, cellulose acetate dimethaminoacetate, cellulose acetate ethyl carbonate, cellulose acetate chloroacetate, cellulose acetate ethyl oxalate, cellulose acetate methyl sulfonate, cellulose acetate butyl sulfonate, cellulose acetate p-toluene sulfonate, cellulose cyanoacetates, cellulose acetate trimellitate, cellulose methacrylates, polysulfones, polyamides, polyurethanes, polypropylene, ethylene-vinyl acetate, polyvinyl chloride, polyvinyl alcohol, ethylenevinyl alcohol, polyvinylidene fluoride and polymethyl methacrylate; and inducing a phase separation to occur. A process for preparing a capsule, said capsule having a shell, said shell comprised of an asymmetric membrane selected from the group consisting of mono-, di- and triacyl cellulose esters wherein said acyl group contains from two to four carbon atoms, alkyl cellulose ethers wherein said alkyl group contains one to four carbon atoms, cellulose acetate butyl sulfonate, cellulose acetate p-toluene sulfonate, cellulose cyanoacetates, cellulose acetate trimellitate, cellulose methacrylates, cellulose nitrate, acetaldehyde dimethyl cellulose, cellulose acetate ethyl carbamate, cellulose acetate phthalate, cellulose acetate methyl carbamate, cellulose acetate succinate, cellulose acetate dimethaminoacetate, cellulose acetate ethyl carbonate, cellulose acetate chloroacetate, cellulose acetate ethyl oxalate, cellulose acetate methyl sulfonate, polysulfones, polyamides, polyurethanes, polypropylene, ethylene-vinyl acetate, polyvinyl chloride, polyvinyl alcohol, ethylenevinyl alcohol, polyvinylidene fluoride and polymethyl methacrylate comprising: coating a mandrel with a solution of a material selected from the group consisting of mono-, di- and triacyl cellulose esters wherein said acyl group contains from two to four carbon atoms, alkyl cellulose ethers wherein said alkyl group contains one to four carbon atoms, cellulose nitrate, acetaldehyde dimethyl cellulose, cellulose acetate ethyl carbamate, cellulose acetate phthalate, cellulose acetate methyl carbamate, cellulose acetate succinate, cellulose acetate dimethaminoacetate, cellulose acetate ethyl carbonate, cellulose acetate chloroacetate, cellulose acetate ethyl oxalate, cellulose acetate methyl sulfonate, cellulose acetate butyl sulfonate, cellulose acetate p-toluene sulfonate, cellulose cyanoacetates, cellulose acetate trimellitate, cellulose methacrylates, polysulfones, polyamides, polyurethanes, polypropylene, ethylene-vinyl acetate, polyvinyl chloride, polyvinyl alcohol, ethylenevinyl alcohol, polyvinylidene fluoride and polymethyl methacrylate; and inducing a phase separation to occur.
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