초록 ▼

A crosslinked, acrylate-based pressure-sensitive adhesive is provided to obtain a creep compliance value of the pressure-sensitive adhesive of between 1.1×10-5 cm2/dyne and 2.3×10-5 cm2/dyne in the presence of alcohol-based excipients, such as ethanol serving as a solvent or a penetration enhancing

A crosslinked, acrylate-based pressure-sensitive adhesive is provided to obtain a creep compliance value of the pressure-sensitive adhesive of between 1.1×10-5 cm2/dyne and 2.3×10-5 cm2/dyne in the presence of alcohol-based excipients, such as ethanol serving as a solvent or a penetration enhancing agent used with transdermal delivery devices. The method of preparing such crosslinked pressure-sensitive adhesive by using electron beam radiation of from 5 kGy to 200 kGy, and medical articles using the crosslinked pressure-sensitive adhesive as a layer therein to contact skin are also provided.

대표청구항 ▼

A method of preparing a pressure sensitive adhesive tolerant of exposure to an alcohol-based excipient used with an active agent for transdermal delivery, comprising: (a) polymerizing at a temperature of at least about 30°C. in the absence of a therapeutic mixture at least one acrylate-based polymer

A method of preparing a pressure sensitive adhesive tolerant of exposure to an alcohol-based excipient used with an active agent for transdermal delivery, comprising: (a) polymerizing at a temperature of at least about 30°C. in the absence of a therapeutic mixture at least one acrylate-based polymerizable monomer and at least one ethylenically unsaturated monomer in a weight fraction ratio of said acrylate-based polymerizable monomer to said ethylencially unsaturated monomer of from about 92:8 to about 98:2 to yield a pressure sensitive adhesive copolymer having an inherent viscosity of from about 1.2 dl/g to about 2.0 dl/g; and then separately (b) irradiating with an electron beam radiation dose of about 5.0 kGy to about 200 kGy the previously polymerized pressure sensitive adhesive copolymer in the absence of photoinitiators needed for ultra-violet polymerization, activators or catalysts needed for chemical crosslinking, and further in the absence of the active agent or the alcohol-based excipient to yield a radiation crosslinked pressure sensitive adhesive useful in a transdermal delivery device having a creep compliance value of from about 1.1×10-5 cm2/dyne to about 2.3×10-5 cm2/dyne after exposure to the alcohol-based excipient.