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BMP-2 products 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-014/435
  • C07K-014/51
  • C12N-015/00
출원번호 US-0655579 (1991-03-18)
발명자 / 주소
  • Wang Elizabeth A. (Carlisle MA) Wozney John M. (Hudson MA) Rosen Vicki (Brookline MA)
출원인 / 주소
  • Genetics Institute, Inc. (Cambridge MA 02)
인용정보 피인용 횟수 : 29  인용 특허 : 26

초록

Purified BMP-2 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

대표청구항

A purified protein produced by the steps of (a) culturing in a suitable culture medium a cell transformed with an expression vector comprising a DNA as shown in FIGS. 2A-C or a degenerative sequence thereof and which encodes a protein containing the amino acid sequence His Pro Leu Tyr Val Asp Phe Se

이 특허에 인용된 특허 (26)

  1. Urist Marshall R. (Pacific Palisades CA), Bone morphogenetic agents.
  2. Urist Marshall R. (Pacific Palisades CA), Bone morphogenetic protein.
  3. Urist Marshall R. (Pacific Palisades CA), Bone morphogenetic protein composition.
  4. Urist Marshall R. (Pacific Palisades CA), Bone morphogenetic protein composition.
  5. Urist Marshall R. (Pacific Palisades CA), Bone morphogenetic protein composition.
  6. Urist Marshall R. (Pacific Palisade CA), Bone morphogenetic protein process.
  7. Caplan Arnold (1300 Oakridge Dr. Cleveland Heights OH 44121) Syftestad Glenn T. (3660 Warrensville Center Rd. - #101 Shaker Heights OH 44122), Bone protein purification process.
  8. Nathanson Mark A. (Philadelphia PA) Reddi A. H. (Kensington MD) Sampath T. K. (Arlington MA), Composition for stimulating bone growth.
  9. Mason Anthony J. (San Francisco CA) Seeburg Peter H. (San Francisco CA), Compositions of hormonally active human and porcine inhibin containing an a 상세보기
  • Evans Ronald M. (San Diego CA) Rosenfeld Michael G. (San Diego CA) Cerelli Gail (Cardiff CA) Mayo Kelly E. (Wilmette IL) Spiess Joachim (Encinitas CA) Rivier Jean E. F. (La Jolla CA) Vale ; Jr. Wylie, Human inhibin.
  • Nathan Ranga (Newark CA) Seyedin Saied (Mountain View CA) Piez Karl (Menlo Park CA) Bentz Hanne (Palo Alto CA), Inductive collagen based bone repair preparations.
  • Hammonds ; Jr. R. Glenn (Berkeley CA) Mason Anthony J. (Burlingame CA), Mammalian expression of the bone morphogenetic protein-2B using BMP2A/BMP2B fusion.
  • Derynck Rik M. A. (So. San Francisco CA) Goeddel David V. (Hillsborough CA), Nucleic acid encoding TGF-b 상세보기
  • Kuberasampath Thangavel (Medway MA) Rueger David C. (West Roxbury MA), Osteogenic devices.
  • Oppermann Hermann (Medway MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (West Roxbury MA) Ozkaynak Engin (Milford MA), Osteogenic devices.
  • Parsons Thomas F. (Arcadia CA) Sen Arup (Van Nuys CA) Grinna Lynn (Santa Monica CA) Hersh Carol (Great Neck NY) Theofan Georgia (Los Angeles CA), Osteogenic factors.
  • Sen Arup (Los Angeles CA), Osteogenic factors.
  • Oppermann Hermann (Medway MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (West Roxbury MA) Ozkaynak Engin (Milford MA), Osteogenic proteins.
  • Oppermann Hermann (Medway MA) Ozkaynak Engin (Milford MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (Hopkinton MA) Pang Roy H. L. (Medway MA), Osteogenic proteins.
  • Kuberasampath Thangavel (Medway MA) Rueger David C. (West Roxbury MA), Osteogenic proteins and polypeptides.
  • Seyedin Saeid (Mountain View CA) Thomas Thomas (Davis CA), Partially purified bone-inducing factor.
  • Seyedin Saeid (Mt. View CA) Thomas Thomas (Palo Alto CA), Partially purified osteogenic factor and process for preparing same from demineralized bone.
  • Seyedin Saeid (Sunnyvale CA) Thomas Thomas (Concord CA) Bentz Hanne (Palo Alto CA) Ellingsworth Larry (San Jose CA) Armstrong Rosa (Palo Alto CA), Polypeptide cartilage-inducing factors found in bone.
  • Seyedin Saeid (Sunnyvale CA) Thomas Thomas (Davis CA) Bentz Hanne (Palo Alto CA) Ellingsworth Larry (San Jose CA) Armstrong Rosa (Palo Alto CA), Polypeptide cartilage-inducing factors found in bone.
  • Seyedin Saeid (Sunnyvale CA) Thomas Thomas (Davis CA) Bentz Hanne (Palo Alto CA) Ellingsworth Larry (San Jose CA) Armstrong Rosa (Palo Alto CA), Polypeptide cartilage-inducing factors found in bone.
  • Seyedin Saeid (Sunnyvale CA) Thomas Thomas (Concord CA) Bentz Hanne (Palo Alto CA) Ellingsworth Larry (San Jose CA) Armstrong Rosa (Palo Alto CA), Polypeptide cartilage-inducing factors found in bone used in tissue proliferation.
  • 이 특허를 인용한 특허 (29)

    1. Wang,Elizabeth A.; Wozney,John M.; Rosen,Vicki A., BMP products.
    2. Wang Elizabeth A. ; Wozney John M. ; Rosen Vicki A., BMP-4 products.
    3. Hair, Gregory A.; Boden, Scott D., Bone mineralization proteins, DNA, vectors expression systems.
    4. Gregory A. Hair ; Scott D. Boden, Bone mineralization proteins, DNA, vectors, expression systems.
    5. Hair Gregory A. ; Boden Scott D., Bone mineralization proteins, DNA, vectors, expression systems.
    6. Hair, Gregory A.; Boden, Scott D., Bone mineralization proteins, DNA, vectors, expression systems.
    7. Li,Rebecca H.; Seeherman,Howard, Calcium phosphate delivery vehicles for osteoinductive proteins.
    8. Baird, Andrew; Gonzalez, Ana Maria; Logan, Ann; Berry, Martin, Compositions and methods for delivery of agents for neuronal regeneration and survival.
    9. Clancy,Brian; Pittman,Debra; Seeherman,Howard, Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins.
    10. Wozney,John M.; Celeste,Anthony J.; Thies,R. Scott; Yamaji,Noboru, DNA molecules encoding BMP receptor proteins.
    11. Kohnert, Ulrich; Pohling, Sylke; Hellerbrand, Klaus; Happersberger, Peter, Device having osteoinductive and osteoconductive properties.
    12. Patel, Shyam; Kurpinski, Kyle, Fibrous polymer scaffolds having diametrically patterned polymer fibers.
    13. Sofia, Susan J.; Schwartz, Daniel; Friess, Wolfgang, Formulation comprising bioactive agents and method of using same.
    14. Li, Rebecca; Seeherman, Howard; Kim, Hyun, Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins.
    15. Li, Rebecca; Seeherman, Howard; Kim, Hyun, Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins.
    16. Kim,Hyun; Li,Rebecca; Pavesio,Alessandra; Callegaro,Lanfranco; Seeherman,Howard; Wozney,John, Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins.
    17. Hellerbrand, Klaus; Beaucamp, Nicola; Kohnert, Ulrich, Metal implant coated under reduced oxygen concentration with osteoinductive protein.
    18. Hellerbrand, Klaus; Beaucamp, Nicola; Kohnert, Ulrich, Metal implant coated under reduced oxygen concentration with osteoinductive protein.
    19. Peel, Sean A. F.; Clokie, Cameron M. L.; Turner, Jeffrey D., Method of enhancing recombinant protein production.
    20. Zhang,Renwen; Peluso,Diane; Morris,Elisabeth, Methods and compositions for healing and repair of articular cartilage.
    21. Bonadio Jeffrey ; Goldstein Steven A., Methods and compositions for multiple gene transfer into bone cells.
    22. Wang,Elizabeth; Wozney,John M.; Rosen,Vicki A., Methods of treatment of periodontal disease.
    23. Sebald,Walter, Polypeptide variants with increased heparin-binding capacity.
    24. Israel, David; Wolfman, Neil M., Recombinant bone morphogenetic protein heterodimers, compositions and methods of use.
    25. Luan,Yen Tung; Stanek,Terry Cardoza; Drapeau,Denis, Restricted glucose feed for animal cell culture.
    26. Clokie, Cameron M. L.; Peel, Sean A. F., System and method for multiphasic release of growth factors.
    27. Peel, Sean A. F.; Clokie, Cameron M. L., System and method for multiphasic release of growth factors.
    28. Celeste,Anthony J.; Wozney,John M.; Rosen,Vicki A.; Wolfman,Neil M.; Thomsen,Gerald H.; Melton,Douglas A., Tendon-inducing compositions.
    29. Celeste,Anthony J.; Wozney,John M.; Rosen,Vicki A.; Wolfman,Neil M.; Thomsen,Gerald H.; Melton,Douglas A., Tendon-inducing methods.

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