초록 ▼

A method is disclosed for using a topical genital lubricant with a non-toxic, non-irritating zinc salt during sexual intercourse. The lubricant is spread upon one or more genital surfaces to create an anti-viral chemical barrier that reduces the risk of infection by the human immunodeficiency virus

A method is disclosed for using a topical genital lubricant with a non-toxic, non-irritating zinc salt during sexual intercourse. The lubricant is spread upon one or more genital surfaces to create an anti-viral chemical barrier that reduces the risk of infection by the human immunodeficiency virus (HIV), the virus that causes AIDS. Suitable zinc salts include zinc acetate, zinc propionate, and other non-irritating water-soluble organic zinc salts that dissociate readily. When dissolved in water, these salts release divalent zinc ions (Zn++), which apparently can reduce HIV infectivity by at least three mechanisms. First, zinc ions form crosslinking bonds with cysteine and histidine residues in proteins (such as the gp120 protein of HIV), thereby “gluing”HIV particles to each other, to proteins in vaginal fluids, and to dead or dying cells that will soon be sloughed off from the genital surfaces. This reduces the ability of the HIV to infect susceptible cells. Second, zinc is the active agent in diaper rash ointments and calamine lotion, and it promotes healing and closure of lesions, microabrasions, and other skin breaches; this reduces the ability of HIV to penetrate the skin and reach lymphocytes. Third, concentrations of zinc that do not harm skin can kill HIV-infected lymphocytes, thereby preventing the lymphocytes from infecting other cells via cell－cell binding mechanisms. The toxicity of zinc to lymphocytes also explains why the anti-HIV activity of zinc was not recognized previously, in standard lymphocyte assays.

대표청구항 ▼

A method of reducing the risk of sexual transmission of human immunodeficiency virus, comprising spreading a topical genital lubricant across genital surfaces that come into intimate contact with a sexual partner during intercourse, wherein the topical genital lubricant contains at least one water-s

A method of reducing the risk of sexual transmission of human immunodeficiency virus, comprising spreading a topical genital lubricant across genital surfaces that come into intimate contact with a sexual partner during intercourse, wherein the topical genital lubricant contains at least one water-soluble organic zinc salt that releases zinc ions in solution, and wherein the topical genital lubricant does not irritate the genital surfaces or cause other adverse effects, and wherein the zinc salt is present in the topical genital lubricant at a concentration that can reduce infectivity of mature HIV particles when mixed with such viral particles in aqueous solution and incubated for two hours at 37°C., and wherein the genital lubricant is characterized by the absence of any deleterious compound at a concentration that would generate a significant adverse effect if applied to genital surfaces and used repeatedly during numerous acts of sexual intercourse.