초록 ▼

Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmo

Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmotically active excipient and not more than about 10% by weight of drug. The system is particularly well suited for delivery of therapeutic macromolecules such as protein drugs. Delivery of epidermal growth factor is exemplified.

대표청구항 ▼

A substantially homogeneous assemblage of particles which when dispersed in a wettable polymeric matrix is useful to deliver a drug which is a protein in low dosage levels to a patient in a sustained and controlled fashion, said particles comprising a substantially homogeneous blend of osmotically a

A substantially homogeneous assemblage of particles which when dispersed in a wettable polymeric matrix is useful to deliver a drug which is a protein in low dosage levels to a patient in a sustained and controlled fashion, said particles comprising a substantially homogeneous blend of osmotically active excipient and said drug which is a protein, wherein said drug component of the particles is not more than about 10% by weight of each particle and the excipient component of the particles is not less than about 90% by weight of each particle.