초록 ▼

Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric mater

Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.

대표청구항 ▼

A method for making a biocompatible polymeric material the method comprising forming a biocompatible copolymer which is selected from the group consisting of copolymers having the formulas (A)x(B)y; (A)x(B)y(A)z; (B)x(A)y(B)z; and a brush copolymer (A)x-(B)y having bristles of poly(A); wherein (A)x,

A method for making a biocompatible polymeric material the method comprising forming a biocompatible copolymer which is selected from the group consisting of copolymers having the formulas (A)x(B)y; (A)x(B)y(A)z; (B)x(A)y(B)z; and a brush copolymer (A)x-(B)y having bristles of poly(A); wherein (A)x, (A)y and (A)z are biocompatible synthetic polymers and mixtures of polymers that form a region which is polynonionic at a pH of between 6.5 and 8.5 and does not bind tissue; and wherein (B)y, (B)x, and (B)z are biocompatible, water-soluble synthetic polymers or mixture of polymers that form a region which is polycationic at a pH of between 6.5 and 8.5 and binds to tissue; and wherein x is an integer of greater than or equal to 5, y is an integer of greater than or equal to 3, and z is an integer of greater than or equal to 0; wherein the polymer has a molecular weight of at least 300 g/mole.