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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0196021 (1994-02-14) |
| 발명자 / 주소 |
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| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 516 인용 특허 : 0 |
Disclosed are devices and methods for analyzing a fluid cell containing sample. The devices are composed of a solid substrate, microfabricated to define at least one sample inlet port and a mesoscale flow system. The mesoscale flow system includes a sample flow channel, extending from the inlet port
Disclosed are devices and methods for analyzing a fluid cell containing sample. The devices are composed of a solid substrate, microfabricated to define at least one sample inlet port and a mesoscale flow system. The mesoscale flow system includes a sample flow channel, extending from the inlet port, and a cell handling region for treating cells disposed in fluid communication with the flow channel. The devices may further include a component for inducing flow of cells in the sample through the flow system. In one embodiment, the cell-handling region may include a cell lysis component to enable the lysis of cells in the sample, prior to, e.g., the detection of an intracellular component in the cell sample. In another embodiment, the cell handling region may have a cell capture region, with binding sites which reversibly bind to a specific population of cells in the cell sample, to permit the isolation of the specific cell population from the sample. The devices can be utilized in a wide range of automated sensitive and rapid tests for the analysis of a fluid cell containing sample.
A method for detecting an analyte in a fluid, cell-containing sample, the method comprising the steps of: (i) providing a device comprising: a solid substrate microfabricated to define: a sample inlet port; and a mesoscale flow system comprising: a sample flow channel extending from said inlet port;
A method for detecting an analyte in a fluid, cell-containing sample, the method comprising the steps of: (i) providing a device comprising: a solid substrate microfabricated to define: a sample inlet port; and a mesoscale flow system comprising: a sample flow channel extending from said inlet port; and a cell handling region for treating cells disposed in fluid communication with said flow channel, said cell handling region comprising a cell lysing structure; and means for detecting an analyte in a fluid sample in said flow system; (ii) delivering a cell-containing fluid sample to the inlet port and through the flow system to the cell lysing structure in the cell handling region thereby to lyse cells in the sample producing a lysed cell sample; and (iii) detecting an analyte in the fluid sample in the flow system with the detection means.
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