초록 ▼

A pumping system for continuously delivering fluid at a selected flow rate to a receiving system. The system includes at least a first and a second pumping unit, each of the individual units comprises a syringe and a valve. The syringe comprises a piston and a piston actuator, cylinder, and pressure

A pumping system for continuously delivering fluid at a selected flow rate to a receiving system. The system includes at least a first and a second pumping unit, each of the individual units comprises a syringe and a valve. The syringe comprises a piston and a piston actuator, cylinder, and pressure sensor. The valve comprises a positively-actuated zero switching volume valve and valve actuator. The first and second pumping units are in fluid communication with one another and are capable of independent actuation. The individual valves are arranged to isolate either the first syringe or the second syringe, respectively, from the receiving system while at least one of the syringes remains in fluid communication with the receiving system whereby system pressure can be continuously monitored and the selected system flow rate maintained. A controller receives inputs from the first and second pressure sensors and activates in response to the inputs the first and second syringes individually, and also activates the first and second valves individually such that when fluid communication is established between the isolated syringe and the receiving system substantially no system flow error is produced. The pressure sensor is positioned within each pumping unit, permitting a pumping unit which has been refilled offline to perform compression of its cylinder contents without perturbation of the on-line process, and which further permits discrimination of the point in the compression cycle where compression has been completed and fluid delivery to the system will commence.

대표청구항 ▼

A pumping system for delivering fluid from a solvent reservoir to a receiving system at a selected flow rate, comprising: a pumping mechanism including a first pumping unit and a second pumping unit, said first pumping unit and said second pumping unit being arranged to continuously deliver said flu

A pumping system for delivering fluid from a solvent reservoir to a receiving system at a selected flow rate, comprising: a pumping mechanism including a first pumping unit and a second pumping unit, said first pumping unit and said second pumping unit being arranged to continuously deliver said fluid from said solvent reservoir to said receiving system, each of said first pumping unit and said second pumping unit comprising, a syringe having an input port, an output port, and a cylinder, a piston dimensioned for actuation within said cylinder and a piston actuator in communication with said piston to effect actuation of said piston; a positively-actuated zero switching volume valve and associated valve actuator selectively operable to enable fluid communication between said solvent reservoir and said input port, to enable fluid communication between said output port and said receiving system, and to isolate said syringe; and a fluid pressure sensor positioned to be in direct fluid communication with said cylinder, enabling continuous monitoring of cylinder pressure, said fluid pressure sensor providing an electrical output signal indicative of cylinder pressure independent of said positively-actuated zero switching volume valve state; and a controller operable for receiving said electrical output signals indicative of cylinder pressure from said fluid pressure sensor of said first pumping unit and from said fluid pressure sensor of said second pumping unit, responsive to control one of said first pumping unit and said second pumping unit as a delivery pumping unit to maintain said selected flow rate to said receiving system and to control the other of said first pumping unit and said second pumping unit to be off-line as an isolated pumping unit being re-filled, and to coordinate establishment of fluid communication between said isolated pumping unit after being refilled and said receiving system and isolation of said delivery pumping unit after delivery, in a manner which substantially avoids system flow error. A gradient chromatography system comprising at least two pumping systems configured according to claim 1 for delivering fluid to a common output line in order to produce a fluid composition gradient, comprising a supervisory controller in electrical communication with the at least two pumping systems whereby the supervisory controller establishes the proportion of solvent composition to be delivered by each individual pumping system to the common output line.