초록 ▼

The invention relates to methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film

The invention relates to methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.

대표청구항 ▼

A method of treating a dermatological disease or condition comprising topical application of efficacious amounts of a liquid polymer composition to the skin of an animal or human, said liquid polymer composition consisting essentially of (a) one or more sustained release acrylic polymers; (b) a phar

A method of treating a dermatological disease or condition comprising topical application of efficacious amounts of a liquid polymer composition to the skin of an animal or human, said liquid polymer composition consisting essentially of (a) one or more sustained release acrylic polymers; (b) a pharmacological agent; (c) a release adjusting agent; and (d) a pharmaceutically acceptable vehicle; wherein said sustained release acrylic polymers are selected from the group consisting of: (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1; (2) a methacrylic acid type B copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2; (3) a dimethylaminoethylacrylate/ethylmethacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20; and (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40; and wherein said release adjusting agent is selected from the group consisting of: a cross-linking agent, a polysaccharide, a lipid, a non-polysaccharide polyhydroxy compound, a polycarboxylic acid salt, a divalent cation of calcium or strontium, a protein, citric acid, a sodium citrate, sodium docusate, polyoxyethylenesorbitan monooleate and an amino acid.