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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0435382 (1995-05-05) |
발명자 / 주소 |
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인용정보 | 피인용 횟수 : 435 인용 특허 : 0 |
The present invention is directed to a method and an apparatus for continuously monitoring the concentration of a metabolite, such as glucose or lactic acid, in biological tissue, in which a perfusion fluid is fed to a microdialysis probe implanted in the subcutaneous tissue and removed therefrom as
The present invention is directed to a method and an apparatus for continuously monitoring the concentration of a metabolite, such as glucose or lactic acid, in biological tissue, in which a perfusion fluid is fed to a microdialysis probe implanted in the subcutaneous tissue and removed therefrom as dialysate after enrichment with the metabolites contained in the lymph. An enzyme is added to the dialysate and/or perfusion fluid, and the concentration of the metabolite in the dialysate is determined under the selective effect of the enzyme at a measuring point which is positioned ex vivo, using an electrochemical sensor. The enzyme is added to the dialysate in the form of a continuous enzyme solution flow upstream of the measuring point and in dependence of the throughput of the microdialysis probe.
A method for continuously monitoring the concentration of a metabolite in biological tissue comprising the steps of: implanting a microdialysis probe in subcutaneous tissue so that it contacts with lymph contained in the subcutaneous tissue; feeding a perfusion liquid to the microdialysis probe wher
A method for continuously monitoring the concentration of a metabolite in biological tissue comprising the steps of: implanting a microdialysis probe in subcutaneous tissue so that it contacts with lymph contained in the subcutaneous tissue; feeding a perfusion liquid to the microdialysis probe whereby the perfusion liquid is enriched with the metabolite contained in the lymph; removing the enriched perfusion liquid as a dialysate from the microdialysis probe; adding an enzyme in the form of an enzyme solution continuously to the dialysate in an amount based on the flow rate of the dialysate to form a dialysate measurement solution; determining the concentration of the metabolite in the dialysate by measuring the dialysate measurement solution ex vivo with an electrochemical sensor; and determining the concentration of the metabolite in the biological tissue based on the concentration of the metabolite in the dialysate.
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