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Transfection of lung via aerosolized transgene delivery 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/64
  • C12N-015/87
  • A61K-048/00
  • A61K-009/127
출원번호 US-0029022 (1993-03-10)
발명자 / 주소
  • Debs Robert James (Mill Valley CA) Zhu Ning (El Cerrito CA)
출원인 / 주소
  • The Regents of the University of California (Oakland CA 02)
인용정보 피인용 횟수 : 115  인용 특허 : 0

초록 ▼

Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes are prepared then delivered via aerosol to the lung airway. The invention provides a direct method for transforming pulmonary

대표청구항 ▼

A composition comprising: a nebulized transfection agent, prepared by nebulizing a mixture comprising complexes between DNA molecules comprising expression cassettes and cationic lipid carriers in a pharmaceutically acceptable carrier, wherein the cationic lipid carriers are in the form of vesicles

이 특허를 인용한 특허 (115)

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